I went to my gastro today for my Imuran refills and bloodwork, and he stated that most of his patients report no real side effects with Imuran. I am going on 3 years + with this drug and I have no side effects...never have. He has patients going on Imuran for over a decade with only positives.
I started at 75 mg, and am now on 150 mg. I do take them all at night. But I do this not because of fatigue or naseousness, but because its easier to remember for me if I coordinate it with toothbrushing at night.
So yes, I do take all three before bed.
I didnt bump up as quickly as you posted though. I think I was on 75 mg for a few months before the promethius test bumped me up to 125 mg.
At any rate...I hope it works for you.