sulphsalazine Allergies

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Gargamel
Regular Member


Date Joined Apr 2006
Total Posts : 172
   Posted 1/29/2008 10:21 AM (GMT -6)   
Hi there,

I just wanted to know the symptoms of a sulphsalazine allergy.

I am currently on 3g a day for about a year and its done nothing for my colitis but has increased my diarrhea and caused me to have a rash on my wrists and arms?

Could this be a symptom of an allergy?

G

basa0806
Veteran Member


Date Joined Feb 2005
Total Posts : 2103
   Posted 1/29/2008 10:27 AM (GMT -6)   
I think when I was on it my lips were extremely puffy.
http://www.medicinenet.com/sulfasalazine/article.htm
If you scroll down to the last paragraph there is a little thing about side effects. If you are really concerned, you should talk to your doctor.

Sam

Diagnosed in September 2004

Currently on...4800mg Asacol, 25mg Elavil, Ortho Tricyclen and some immodium

"If you don't like something, change it. If you can't change it, change your attitude"

Maya Angelou


tjf
Veteran Member


Date Joined Dec 2005
Total Posts : 3238
   Posted 1/29/2008 10:33 AM (GMT -6)   
I'm allergic to sulfa and it gave me a debilitating migraine. My dad is allergic and he broke out into a rash all over his body. How long have you been taking it? My allergy showed up right away.

I deleted your duplicate post:)
Tabitha (Tab)

100mg Azathioprine, 2 Fibercon, Colazal-9 a day, Acidopholis Pearls, Nexium

http://www.healingwell.com/donate
Co-Moderator UC Forum


Gargamel
Regular Member


Date Joined Apr 2006
Total Posts : 172
   Posted 1/29/2008 10:52 AM (GMT -6)   
Looking at the side effects on the website link, I would say that I have experienced some of them over the last year.

Feeling tired, muscle weakness, diarrhea, dizzyness and a skin rash...

I don't think these are extremely serious but considering that Salphasalazine isn't helping my colitis I might stop it altogether.

Although I have read that a drug called Ketotifen has helped people with Salphsalazine allergies and improved their colitis in turn.

G

quincy
Elite Member


Date Joined May 2003
Total Posts : 30971
   Posted 1/29/2008 11:17 AM (GMT -6)   
Sounds as though it is an allergy...and if you continue on it, it could turn out much worse.

How are you on just 5ASA?

I've not heard of Ketotifen..must check it out.

q
*Heather*Status: mini flare Dec 28... tapered to every second night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....bromelain 1 - 2x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


Gargamel
Regular Member


Date Joined Apr 2006
Total Posts : 172
   Posted 1/29/2008 11:44 AM (GMT -6)   
Quincy, the only reason I am on Salphasalazine is because Asacol and Pentasa didn't help my colitis.

I usually saw the red Asacol tablets end up at the bottom of the toilet bowl unbroken and the Pentasa granuales also went through me with no effect.

G

tjf
Veteran Member


Date Joined Dec 2005
Total Posts : 3238
   Posted 1/29/2008 12:20 PM (GMT -6)   
Any luck w/ Colazal?
Tabitha (Tab)

100mg Azathioprine, 2 Fibercon, Colazal-9 a day, Acidopholis Pearls, Nexium

http://www.healingwell.com/donate
Co-Moderator UC Forum


Red_34
Elite Member


Date Joined Apr 2004
Total Posts : 23551
   Posted 1/29/2008 12:24 PM (GMT -6)   
I am extremely sensitive to sulfa. I have a wide array of symptoms when I take it. My first symptom was large painful welts all over the lower half of my body - I looked like someone took a cat o' nine tails to my body. Then I was put on Bactrim for a kidney infection (I didn't know Bactrim had sulfa) and I had such severe deblilating abdominal pains, increase massive D, upper chest pain and muscle pain.
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc -'92 - Colazal (9 daily), 6mp (50-100mgs), Colocort, Prilosec, Biotin, Forvia, Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa** ~Allergies - Allegra & Singulair
~Secondary Reynauds Syndrome - '04 - Norvasc~Fibromyalgia - '06~No meds
To help Healingwell - click here: DONATE
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"The quality of my life depends on the quality of my thoughts."
 
 
 
 

 
 


quincy
Elite Member


Date Joined May 2003
Total Posts : 30971
   Posted 1/30/2008 4:29 AM (GMT -6)   
Sherry...that's probably why you can't use the Rowasa...it's preservative is potassium metabisulfite.

q
*Heather*Status: mini flare Dec 28... tapered to every second night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....bromelain 1 - 2x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


Red_34
Elite Member


Date Joined Apr 2004
Total Posts : 23551
   Posted 1/30/2008 7:07 AM (GMT -6)   
Very possible Q! :)
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc -'92 - Colazal (9 daily), 6mp (50-100mgs), Colocort, Prilosec, Biotin, Forvia, Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa** ~Allergies - Allegra & Singulair
~Secondary Reynauds Syndrome - '04 - Norvasc~Fibromyalgia - '06~No meds
To help Healingwell - click here: DONATE
http://www.myspace.com/82595818
"The quality of my life depends on the quality of my thoughts."
 
 
 
 

 
 


princesa
Veteran Member


Date Joined Aug 2007
Total Posts : 2204
   Posted 1/30/2008 10:39 AM (GMT -6)   

Some folks that experience allergic reactions can be desensitized:

In mild to moderate cases of Crohn's disease, sulfasalazine therapy should be instituted gradually, initially 1 to 2 tablets (500 mg) daily and increased by 500 mg doses to 2 to 4 g daily. Sulfasalazine should be administered in four divided doses, with meals and with a light snack at night. Although there are numerous clinicians who advise dosages up to 12 g each day, I have found that the evidence of side-effects precludes this level of medication in most patients. Side-effects are often dose related, reflect serum sulfapyridine levels, which can be identified in individual patients and then used as a guide to the dosage of sulfasalazine. Nausea and headache, the earliest side-effects, can be alleviated by temporarily lowering the dosage. To avoid the development of upper gastrointestinal side- effects (heartburn, epigastric discomfort), the coated tablet (Azulfidine-EN) can be used. Such allergic manifestations as skin rashes and fevers are not uncommon, but do not constitute a contradiction to further usage of sulfasalazine. My colleague, Burton Korelitz, and I have demonstrated that approximately 90 percent of patients with Crohn's disease who have allergic reactions to sulfasalazine can be successfully desensitized. ****We use initial dosages of one-eighth to one-fourth tablet daily for one week, with subsequent doubling of dosages on a weekly basis until all patients reach therapeutic dosage. For example, we give one-fourth of a tablet daily for one week, then one-half tablet daily for one week, then one tablet daily for one week, and so on. Approximately three of four patients have shown clinical improvement following desensitization. Additional information on desensitization is provided in the chapter on ulcerative colitis therapy.****


Diagnosed with ulcerative colitis spring 1999.
 
Therapeutic dose sulfasalazine.
Probiotics, l-glutamine and fish oil caps. George's aloe vera juice and Mucosaheal. Oregano oil antibiotic, antiviral, antifungal.
 
 


blessteve
Regular Member


Date Joined Jan 2008
Total Posts : 121
   Posted 1/30/2008 10:43 AM (GMT -6)   
Major migraines. Deathly sick with alcohol. That stuff just made me sicker yet I was on
it for years.
 
Call Doc ask for something else. If is not helping you then you shouild try different med.
Diagnosed panColitis 1990.
Current Meds Asacol x4 twice a day. X6 1/15/08
Pred for flares. I still have my colon THANK YOU GOD!!!
vitamins-veggie juice-wheat grass juice--fish oil
Started 1/01/08
Freindly bacteria:raw milk-kefir made with raw milk--natto--probiotics
Antifungus:Caprylicacid, Pau D Arco, Black walnut hull, Oregano oil
grape seed extract.
Anti inflammatory:fish oil  1/15/08 started Turmeric
1/10/08 Started healthy diet again.1/22/08 cultued veggies
 
 

Post Edited (blessteve) : 1/30/2008 8:46:24 AM (GMT-7)


Mitzo
Veteran Member


Date Joined Dec 2007
Total Posts : 536
   Posted 1/30/2008 6:01 PM (GMT -6)   
I have a sulpha allergy too. i was put on humatin last summer and am still stuggling with the diarrhea it caused, and I want to ask if anyone knows if humatim paromomycin is a sulpha drug? Also, does a reaction to it die off over time?
21 years of UC which started after quitting smoking. In and out of flares which are usually triggered by antibiotics.
  • Salofalk enemas each 2nd day
  • 8 500mg Pentasa a day
  • Probiotic
  • Psyllium powder.


BTV 05401
New Member


Date Joined Jan 2005
Total Posts : 9
   Posted 2/1/2008 4:18 PM (GMT -6)   
Mitzo,
Humatin is Paromomycin SULFATE. I am shocked that a Doctor would put you on that if you have a sulfa allergy. Even the pharmacy that dispensed it probably shouldn't have given it out.

Mitzo
Veteran Member


Date Joined Dec 2007
Total Posts : 536
   Posted 2/1/2008 8:55 PM (GMT -6)   
BTV 05401, the doctor has since retired and I am still unable to overcome the diarrhea that the humatin caused. My UC flare from the flagyl he prescribed has gone now, but this diarrhea remains and the docs, new GP and gastro, do not seem to have an answer as to what to do. If I overdose on pentasa it helps, but otherwise, oh my god...
21 years of UC which started after quitting smoking. In and out of flares which are usually triggered by antibiotics.

 

  • 6 500mg Pentasa a day
  • Probiotic
  • Psyllium powder.


Mitzo
Veteran Member


Date Joined Dec 2007
Total Posts : 536
   Posted 2/1/2008 9:00 PM (GMT -6)   
Pentasa is a 5-asa and a sulpha thing too, isn't it?
21 years of UC which started after quitting smoking. In and out of flares which are usually triggered by antibiotics.

 

  • 6 500mg Pentasa a day
  • Probiotic
  • Psyllium powder.


quincy
Elite Member


Date Joined May 2003
Total Posts : 30971
   Posted 2/2/2008 3:54 AM (GMT -6)   
No sulfa in Pentasa oral....although the enemas might have metabisulfite in it as do the other 5ASA enemas.
*Heather*Status: mini flare Dec 28... tapered to every second night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....bromelain 1 - 2x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


Mitzo
Veteran Member


Date Joined Dec 2007
Total Posts : 536
   Posted 2/2/2008 10:42 AM (GMT -6)   
Well then, Quincy, that explains why when I was using salofalk mesalamine enemas I was in diarrhea overdrive for 2 months.

I wonder if there is any way to get the humatin sulpha aftereffects under control. I seem to have returned to a baseline level of liquid diarrhea daily, no blood or mucous or UC-type pains, just the diarrhea.

As I said, my doctors do not seem to have a clue what to do about it. I have 2 more appointments lined up soon, but I have a feeling they are fed up with me on this.
21 years of UC which started after quitting smoking. In and out of flares which are usually triggered by antibiotics.

 

  • 6 500mg Pentasa a day
  • Probiotic
  • Psyllium powder.


julee70
Regular Member


Date Joined Oct 2007
Total Posts : 486
   Posted 2/2/2008 11:18 AM (GMT -6)   
Hey Gargamel,
I hope you've stopped the sulphasazine by now. My rash also started on my arms (and hands). That was on day 7 or so. By the next day, I had a fever and was pretty miserable. I hope you haven't gotten to that point!

Personally, I'd start trying to find a different 5ASA drug that might work for you. They're all a little different so you never know... maybe one will work for you.

I'm going to check out Ketotifen online now. I've never heard of it.
-------
UC for the last ten years
Current Meds: 6MP
Past Meds: You name it; I've tried it.


Gargamel
Regular Member


Date Joined Apr 2006
Total Posts : 172
   Posted 2/2/2008 12:13 PM (GMT -6)   
My GI has suggested that I try a new 5 ASA called Lialda (Mezavant) ...

I hear that you take less tablets and hopefully it should be safer.

G

quincy
Elite Member


Date Joined May 2003
Total Posts : 30971
   Posted 2/2/2008 12:33 PM (GMT -6)   
The dosaging would be the same basically...each pill is 1200mg compared to Asacol which is 400mg. So, basically, each pill is = 3 asacol.

It is time-released, so in that way, one might end up taking less meds. I would think that starting lower dosaging and increasing would be the best way to go rather than starting with a higher dosage and tapering.....the reason is some 5ASA meds create some of the very symptoms of UC....

Let us know how it goes for you.

quincy
*Heather*Status: mini flare Dec 28... tapered to every second night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....bromelain 1 - 2x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


Gargamel
Regular Member


Date Joined Apr 2006
Total Posts : 172
   Posted 2/2/2008 2:18 PM (GMT -6)   
How would you know if you are allergic to 5 ASA altogether.

And what would be the next best treatment for somebody with moderate/severe Ulcerative Colitis.

G

quincy
Elite Member


Date Joined May 2003
Total Posts : 30971
   Posted 2/2/2008 2:51 PM (GMT -6)   

I would say allergy would be more systemic....and side effects could be more specific.

Your next step would be steroid meds...you could start with oral (entocort) and rectal (either foam or liquid).

Are you using any rectal 5ASA meds as well at this time?

q


*Heather*Status: mini flare Dec 28... tapered to every second night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....bromelain 1 - 2x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

Post Edited (quincy) : 2/2/2008 12:54:37 PM (GMT-7)


Gargamel
Regular Member


Date Joined Apr 2006
Total Posts : 172
   Posted 2/2/2008 3:24 PM (GMT -6)   
I am using a steroid enema called Predsol, but I think I need an oral anti-inflammatory medicine as well because my colitis goes all the way round.

G

Trsora1
Regular Member


Date Joined Nov 2007
Total Posts : 111
   Posted 2/12/2008 10:18 AM (GMT -6)   
if you are allergic to pentasa which i have been on since september and high dosage of steriod. So im coming off steriods breaking out in rash on my face, whole body itches. On saturday had an issue with food allergey testing and all of that came back negative but broke out in a huge red rash and they had to use the ephrine pen on me. They thought i was allergic to glycerin a perservative in the testing kit. Any ideas?
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