Advice would be appreciated

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pupluv
Regular Member


Date Joined May 2007
Total Posts : 256
   Posted 1/31/2008 11:43 AM (GMT -7)   
Hi guys, I know I'm on very sporadically, but your're always so helpful. I am tryinig to make a decision and would benefit from people who are living this. I have been on Imuran/Aza for about a year now. Before getting on Aza, I was flaring up very frequently(about every other month). Since being on the Aza, I've been doing much better, I flared up about 3x's last year, but it was very mild and didn't last long. But I had a mild flare up at end of November and am feeling the symptoms of another one coming on. This one doesn't feel as mild as the others have been. Anyway, my GI said that he would like to up my Aza from 100 to 125mgs. My prometheus test showed that I was very close to theraputic range. He wants to try this and take another prometheus test to make sure I don't go over the range. I really didn't want to take more and I am very nervous about going over theraputic range even for a short time. I already have a low WBC count without being on Aza. Not sure what to do.
Thanks guys,
Donna
Donna
Diagnosed with indeterminate colitis in 1992
current meds
4 asacol 3x's a day
Azathioprine
Rowasa enemas as needed
VSL3
Bunches of vitamins


cycling_sasquatch
Regular Member


Date Joined May 2007
Total Posts : 167
   Posted 1/31/2008 2:08 PM (GMT -7)   
My DOC just upped me to 200. I was still well below the therapeutic range. I was a little bit nervous, and he says I don't need to get bloodwork done for a month, but I trust him. I guess that doesn't help, but I think you'll be fine.
Dx Left-sided UC Dec. 2006
Currently:
Azathioprine 200mg/day
Prednisone 2.5; 7.5; 10/7.5mg(trying to taper-started at 60 6/1)
Lialda 2/day
Multivitamin, B complex vit., fish oil, calcium, fiber supplement, probiotic


pupluv
Regular Member


Date Joined May 2007
Total Posts : 256
   Posted 2/1/2008 9:45 AM (GMT -7)   

I think I woudn't be so nervous if I weren't so close to the theraputic range. Thank you for responding.

Donna


Donna
Diagnosed with indeterminate colitis in 1992
current meds
4 asacol 3x's a day
Azathioprine
Rowasa enemas as needed
VSL3
Bunches of vitamins


jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10407
   Posted 2/1/2008 10:01 AM (GMT -7)   
Pupluv, that's a small increase. They usually up it by 50mg at a time. As long as you're followed with blood tests, there shouldn't be a problem. When I changed GI's, the first Prometheus the new doc did came back above range and he decreased the dosage. I never had any symptoms and haven't had any problems in the four years since.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Colazal,  Remicade, Nature's Way Primadophilus Reuteri.
In remission since April, 2006. Remicade has been my wonder drug.
 
Co-Moderator UC Forum


UCinNC
Veteran Member


Date Joined May 2007
Total Posts : 528
   Posted 2/1/2008 10:06 AM (GMT -7)   
Hi Donna - I think that if you trust your GI, you should go with it. I know that sounds like stupid advice, but my experience thus far has been that my GI has never steered me in the wrong direction, even when I was nervous about something. The 2 times I was nervous about his suggestion I got a second opinion at a major GI clinic at UNC-Chapel Hill, and both times they agreed with him, so now I trust my GI. If you trust your doc, I would go for the increase. A good doc has your total health in mind when treating UC, and won't do something that endangers your overall health. I agree with Judy that a 25mg increase is very slight.... and, for what it is worth, my GI says Imuran dosing is as much an art as a science, so you have to play around a bit. my GI said that apparently, at the Cleveland Clinic, they determine the therapeutic dose by actually dosing the person until the WBC drops too low, and then they pull back just enough to get it up into a better range.... my point being that people can take pretty high doses of this drug. good luck.
30/Female/NC
Pancolitis dx 3/07
9 Colazal a day (was on 12 Asacol/day, but suddenly got sick from it)
150mg Imuran/day (steroid dependent, reached this dose 9/07)
Various vitamins, bit of fish oil, a probiotic.


pupluv
Regular Member


Date Joined May 2007
Total Posts : 256
   Posted 2/1/2008 11:59 AM (GMT -7)   

Thank you for you responses. I do trust my GI, he's awesome. I was really hoping that this would do it, now I may have to increase dosage. I am flaring up too much and I guess I will let the Doc do his thing. Thanks again for helping with this decision.

Donna


Donna
Diagnosed with indeterminate colitis in 1992
current meds
4 asacol 3x's a day
Azathioprine
Rowasa enemas as needed
VSL3
Bunches of vitamins

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