Vit. D supplements may be immunosuppressive

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Sara14
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Date Joined Mar 2007
Total Posts : 4538
   Posted 1/31/2008 8:27 PM (GMT -6)   
This study showed that ingested Vit. D supplements may be immunosuppresive and that supplementing with the vitamin may make chronic diseases worse. It doesn't say anything about UC, though it does mention autoimmune diseases in general. I wonder if it being immunosuppressive for UCers might be a good thing...?
 
 
This seems to be saying the opposite of some of the things said in an article on Vit. D from Scientific American (posted here by relativelyquantum a few weeks ago).


24 years old
Diagnosed with UC March 2007; yet to go into remission
Asacol 4 tablets 3x/day
Rowasa (generic) - daily
Nature's Way Primadophilus Reuteri 1/day; Chewable multivitamin; Metamucil; Viactiv (Calcium and Vit. D); fish oil


relativelyquantum
Regular Member


Date Joined Sep 2007
Total Posts : 196
   Posted 1/31/2008 9:03 PM (GMT -6)   
Good counterpoint. Notice they were speaking about 'ingested' vitamin D, because there are different forms and I think most would agree that the sun is the best source. The normal assumption is just intaking more vitamin D will help and sometimes it does (especially if you are getting no sun), but other times it can be dangerous with very high levels (like 20,000% or so of the daily value). This article seems to suggest that even "nominal" levels may not be the best, which is intriguing. Other studies seem to suggest that the activated form "1,25D" may actually benefit people with UC (maybe because it suppresses the immune system?). I wonder what will become of it all. Thanks for the post.
Pancolitis '04
Yet to ever go into remission, additional Flare-up since Aug 12th
Time off work since 10/17.  Returned to work on 1/11 and doing much better.
 
On Lialda (2/dy), Probiotics, Fish Oil, Folic Acid, Alpha Lipoic Acid, Borage Oil, Iron


princesa
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Date Joined Aug 2007
Total Posts : 2204
   Posted 1/31/2008 9:22 PM (GMT -6)   
That is interesting. Dr. Ronald Hoffman's Web site offers this information on a link between IBD and Vitamin D deficiency:
 

Vitamin D deficiency may be more common in people who have inflammatory bowel disease. Vitamin D deficiency may worsen the symptoms of Crohn's disease, but it's still unclear whether lack of the vitamin could be a cause, or simply an effect of the disease.

In a study, genetically engineered mice set to develop Crohn's disease and ulcerative colitis, were divided into two groups. Half were starved of vitamin D in their diet, while the other half were given a supplement. The treated mice not only had less bowel inflammation, but also survived when the untreated mice started dying after only a few weeks.

The research team pointed out other factors, which might suggest a link between IBD and vitamin D. Rates of IBD are higher in North America and Northern Europe, which receive less sunlight. However, a UK expert questioned whether vitamin D was the principal factor behind the high rates of Crohn's disease. Dr. Nick Thompson, a consultant gastroenterologist, carried out a study of 250 Crohn's patients and found only three who could be classified as Vitamin D deficient. He also pointed out that rickets has virtually disappeared in recent years, while Crohn's has soared.

It is interesting to note that patients with Crohn's disease may actually have high levels of vitamin D in their blood, indicating risk for toxicity if they took additional vitamin D. It may not be the best idea to start prescribing vitamin D for patients without testing 25 hydroxyvitamin D levels. As Abreu's team explains in the medical journal Gut, under certain circumstances too much active vitamin D can actually contribute to the breakdown of bone, leading to osteoporosis. In that same journal, researchers found "inappropriately high" blood levels of the active form of vitamin D in 42 percent of the 138 people they studied with Crohn's disease. This was true of only 7 percent of 29 patients with ulcerative colitis. In addition, the higher the blood levels of active vitamin D in Crohn's patients, the lower their bone density -- regardless of whether they were treated with steroids. The researchers believe that high vitamin D levels are most likely a manifestation of the underlying gut inflammation. Immune system cells produce vitamin D as part of the immune response (vitamin D is required for cell differentiation).

Bottom line: get a 25 hydroxyvitamin D blood test for patients with Crohn's or colitis. It seems that colitis patients are better candidates for medically supervised vitamin D therapy.


Diagnosed with ulcerative colitis spring 1999.
 
Therapeutic dose sulfasalazine.
Probiotics, l-glutamine and fish oil caps. George's aloe vera juice and Mucosaheal. Oregano oil antibiotic, antiviral, antifungal.
 
 


mudua
Regular Member


Date Joined Apr 2007
Total Posts : 459
   Posted 2/2/2008 1:52 PM (GMT -6)   

I live in Cape Town South Africa and here we get winter rainfalls. My UC symptoms are far worse in summer when we have sunny skies almost everyday. My UC symptoms ease in Winter when it's usually cold and rainy with very little sunshine.

 


Sara14
Veteran Member


Date Joined Mar 2007
Total Posts : 4538
   Posted 2/3/2008 11:54 PM (GMT -6)   
hmmmm...interesting, mudua. I think I feel better in summer, when it's sunny.
24 years old
Diagnosed with UC March 2007; yet to go into remission
Asacol 4 tablets 3x/day
Rowasa (generic) - daily
Nature's Way Primadophilus Reuteri 1/day; Chewable multivitamin; Metamucil; Viactiv (Calcium and Vit. D); fish oil


UCinGV
Regular Member


Date Joined Mar 2007
Total Posts : 403
   Posted 2/4/2008 11:23 AM (GMT -6)   
I've been taking 1,000 IU of Vitamin D suppliments for the last 60 days or so. I've felt a lot better, but this is likely due to the Imuran finally taking hold (Imuran takes a few months to start working well.)
12 Asacol
100 mg Imuran


love4cats
Regular Member


Date Joined May 2007
Total Posts : 458
   Posted 2/4/2008 11:46 AM (GMT -6)   
My flares seem to happen in Feb/March.
 
 
Dx:  UC Proctitis 2006
 
Meds:  None so far. Garlic works to ease flares. My GI laughed when I told him and said it was just coincidence.
 
Diet:  Regular fresh garlic, Biobest yogurt daily, Omega 3 supplements, very limited junk food, carbs and processed food, low fat diet.  Lots of fresh fruit and veggies (limited potatoes). 
 
Added: tumeric and probiotics.
 
 


princesa
Veteran Member


Date Joined Aug 2007
Total Posts : 2204
   Posted 2/4/2008 3:37 PM (GMT -6)   
love4cats said...
My flares seem to happen in Feb/March.

Same here. My first horrendous flare happened during this time, then a year later almost to the very day, I was back in the ER. As I recall it was Valentine's Day night. Not my idea of a romantic evening.
 
After that, I started using a full-spectrum light box once or twice a day during the late fall, winter and early spring. It's helped, but I was definitely prone to some seasonal affective symptoms before the UC happened.
Diagnosed with ulcerative colitis spring 1999.
 
Therapeutic dose sulfasalazine.
Probiotics, l-glutamine and fish oil caps. George's aloe vera juice and Mucosaheal. Oregano oil antibiotic, antiviral, antifungal.
 
 


Red_34
Elite Member


Date Joined Apr 2004
Total Posts : 23551
   Posted 2/5/2008 7:54 AM (GMT -6)   
I'm the same way as Sara, I feel a lot better in the summer months with plenty of sunshine as opposed to winter. Michigan in the winter is so super gray and cloudy about 95% of the time that it can get to a person - even a healthy person! I have a light box too because it helps with my SAD but honestly I don't think it helps with my Uc symptoms at all. So I think for me, I benefit better from natural sunlight overall.
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~Left sided Uc -'92 - Colazal (9 daily), 6mp (50-100mgs), Prilosec, Biotin, Forvia, Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa** ~Allergies - Singulair
~Secondary Reynauds Syndrome -'04 - Norvasc~Fibromyalgia -'06~No meds
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