Questions about Prednisone

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New Member

Date Joined Jan 2008
Total Posts : 7
   Posted 2/4/2008 8:43 AM (GMT -6)   
Because of a flare that began about 2 weeks ago, my doctor put me on 40 mg of Prednisone for a week, tapering down to 20 mg for five days. I'm 26 weeks pregnant and my daily asacol and pentasa doses didn't seem to be doing the trick. I've only been on the Prednisone for three days now, but was wondering if you all know about how long it should take to start its magic. The only noticeable difference I see so far is less blood in my bm's. I'm still having terrible cramping in the morning and night accompanied by very loose stools (5-6 a day).

Also, my doctor stressed to me upon my initial diagnoses that my case was "very, very mild". Do you happen to know if cases that originally start off as mild can/often do turn to more serious cases?

Thank you in advance for your replies.
diagnosed with a mild case of ulcerative colitis June, 2007
asacol, 2 pills three times a day
daily pentasa enema
started 40 mg prednisone 2/08

Elite Member

Date Joined Mar 2003
Total Posts : 10407
   Posted 2/4/2008 8:48 AM (GMT -6)   
Cocolicious, like everything else with this DD, we tend to respond differently. Often Pred will be effective within 24 hours, but for some it takes five days or more. You've said that you're having less bleeding, so it seems to be starting to take effect.

UC can indeed worsen, but in this case it could also be related to your pregnancy. Some women report that their UC gets worse during pregnancy.

I hope you're soon feeling much better. And congratulations on your pregnancy!
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Colazal,  Remicade, Nature's Way Primadophilus Reuteri.
In remission since April, 2006. Remicade has been my wonder drug.
Co-Moderator UC Forum

Regular Member

Date Joined May 2007
Total Posts : 169
   Posted 2/4/2008 5:05 PM (GMT -6)   
I've had prednisone start working anywhere from as little as a few hours to a week. I'd give it some time. Yes, you might get worse, but you also might get better! Heck, some people have an initial case flare and then never have problems ever again. Think positive!
Dx Left-sided UC Dec. 2006
Azathioprine 200mg/day
Prednisone 2.5; 7.5; 10/7.5mg(trying to taper-started at 60 6/1)
Lialda 2/day
Multivitamin, B complex vit., fish oil, calcium, fiber supplement, probiotic

Veteran Member

Date Joined Jul 2007
Total Posts : 2148
   Posted 2/5/2008 10:50 AM (GMT -6)   
I don't know how long it took for me, I was on pred for 2 months before I got better for my UC and also my kidneys it took 4 months and it was almost considered a failure for my kidneys (on it for a dual purpose).  I find out Thursday how I am doing w/that.
Also, I belive the hydrocortisone enema's are really what jumpstarted my remission.  It took about 2 weeks to get some good results.
Beth, 32
Major Flare Sept/Oct 07 ~ working on remission almost there
UC dx'd March 2000 (30 cenitmeters as of 2005-proctosigmoiditis)
Azathioprine 200mg 1xday nightly; Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Probiotics.
Minimal Change Disease (Kidney Disorder) Diagnosed Sept 2007
Prednisone 60/40mg alt days 1xday, Simvastatin 20mg 1xday, Diovan 160mg 2xday. Potassium 600mg 2xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.

Regular Member

Date Joined Nov 2007
Total Posts : 26
   Posted 2/5/2008 1:26 PM (GMT -6)   
Hi cocolicious,

I'm also pregnant (28 weeks tomorrow) and had a terrible flare in my 2nd trimester. My GI put me on 40mg prednisone to start but it didn't work, so he upped it to 50mg. That also didn't work. I ended up going into the hospital for 3 days for IV fluids/steroids and they also put me on Salofalk enemas. I've been flare free (no blood, no cramping, no frequency) for 6 weeks now. My advice is if you don't start seeing improvement soon look into IV steroids at the hospital. I was hesitant to do it, but now I'm so glad I did!

Good luck with everything! I know how scary a flare can be when you're pregnant!

Diagnosed: July 2007
Pregnant: Due 05/2008
Meds: Salofalk enema (nightly), 15mg prednisone, Salofalk pills (8X/day)
Other: prenatal vit., probiotics, calcium, folic acid, fish oil.

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