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maddypoo
New Member


Date Joined Feb 2008
Total Posts : 6
   Posted 2/10/2008 3:10 AM (GMT -6)   
 
Hi, all. I went to see my consultant on Friday, thought all would be well as I have been taking 60mg pred for the past two weeks and even though it made me feel pretty weird it had started to slow down the bm's. I lay on the couch for him to look at my tum and all was well. He then looked at my blood results and said there was a problem, the high dose of Azathioprine has started to affect my liver function and blood count. He has now taken me off all medication (except 60mg pred) for two weeks to rest my liver, then I will go back to Azathioprine 50mg as well as a new tablet (to me) called Allopurinol, has anyone else taken this? and taper the pred in 10mg stages.  I am very worried about what is going to happen during the two weeks I am not on medication, will I go backwards? Will the pred hold me up?. Apparently if this new combination doesn't work I will have to come off Azathioprine and start something else. Do I really want to be a guinea pig for more drugs or have I no choice? Sorry to be moaning but am sooooo fed up.

Medications so far: Feb '07:Prednisolone 5mg (1 week), Prednisolone Foam Enema,
Mar '07 Pentasa tabs 200mg x2 daily, 
Apr '07 Colazide caps 750mg x9 daily,
May '07 Omeprazole 20mg, Prednisolone 30mg taper to 0mg (6 week taper) Colifoam enema, Nystatin (oral thrush),
June '07 Pentasa retention enema,
July'07 Pentasa suppositories,
Sept '07 Salofalk foam enema, Prednisolone (6week taper) 30mg to 0mg,
Nov '07 Azathioprine 12mg, Prednisolone (6 week taper) 30 to 0mg,
Jan '08 Prednisolone 15mg two weeks, 10mg two weeks. Up dose of Azathiporine to 175mg
Jan'08 Prednisolone up to 60mg  


Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 23551
   Posted 2/10/2008 7:32 AM (GMT -6)   
Of course you don't have to take any med if you don't want to. However, if you don't do something to help your Uc, it could make things much more worse and possibly even hospitalization. I know the frustration of medications - going thru the same thing myself sort of. No one can say if you are going to go backwards when coming off Aza, but I sincerely hope not!

Also, never apologize for a vent! That is what a support forum is for :)
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc -'92 - Colazal (9 daily), 6mp (50-100mgs), Prilosec, Biotin, Forvia, Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa** ~Allergies - Singulair
~Secondary Reynauds Syndrome -'04 - Norvasc~Fibromyalgia -'06~No meds
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jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10407
   Posted 2/10/2008 9:28 AM (GMT -6)   
Maddy, azathioprine breaks down in the body in different ways for different people. Some get more of the toxic product, some more of the beneficial one. There have been studies that showed allopurinol helps your body to break the aza down in a different way, preventing the buildup of the toxic metabolytes. So, if all goes as planned, it should help you tolerate the aza and help the aza do its job.

This is a convenient web site to research the medications you take. Just type in the name of the drug and it'll give you lots of information about it.

http://www.medicinenet.com/script/main/hp.asp
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Colazal,  Remicade, Nature's Way Primadophilus Reuteri.
In remission since April, 2006. Remicade has been my wonder drug.
 
Co-Moderator UC Forum


maddypoo
New Member


Date Joined Feb 2008
Total Posts : 6
   Posted 2/10/2008 2:10 PM (GMT -6)   
Thanks very much for your replies, I am really grateful to be able to talk to you and vent! as you say. I think I am maybe just having a little down time at the moment but I will pick myself up and battle on with this crazy disease. Thank you Judilyn for explaining the azathioprine a little more for me, I did listen to the doc but I think some info stayed there and some came out the other side ha ha. I have researched the allopurinol I just wondered if anyone else had been put on it. Again thanks.

Medications so far: Feb '07:Prednisolone 5mg (1 week), Prednisolone Foam Enema,
Mar '07 Pentasa tabs 200mg x2 daily, 
Apr '07 Colazide caps 750mg x9 daily,
May '07 Omeprazole 20mg, Prednisolone 30mg taper to 0mg (6 week taper) Colifoam enema, Nystatin (oral thrush),
June '07 Pentasa retention enema,
July'07 Pentasa suppositories,
Sept '07 Salofalk foam enema, Prednisolone (6week taper) 30mg to 0mg,
Nov '07 Azathioprine 12mg, Prednisolone (6 week taper) 30 to 0mg,
Jan '08 Prednisolone 15mg two weeks, 10mg two weeks. Up dose of Azathiporine to 175mg
Jan'08 Prednisolone up to 60mg  

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