First encounter with azathioprine

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Regular Member

Date Joined Feb 2008
Total Posts : 42
   Posted 2/12/2008 10:05 AM (GMT -6)   
Hi there
I was diagnosed with UC when i was 18 ( nearly 12 years ago now ) and have had a few flare ups which have been brought under control with steriods , but recently I am having trouble getting back to normal .
the consultant has given me a dose of 40mg pred   ( normally never went above 20mg )  and has given me azathioprine to take at 25mg a day
Reading all about it i have heard that people are sick with it , can you please suggest a good time of day period before or after food for taking this stuff
It sounds terrible but I cant stand that thought of loosing any food at the moment ! , is it best to take just before bed ( if i havnt eaten for 1 hour beforehand )
Also any advice on this treatment would be greatly appreciated

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 2/12/2008 10:20 AM (GMT -6)   
I started taking 6mp (which is the purer form of AZA) in the mornings per my docs instructions but on recommendation of everyone here, I started taking it at night before bed because I was getting nauseas. It helped tremendously to take it at night.

Btw, welcome to Healingwell :)
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc -'92 - Colazal (9 daily), 6mp (50-100mgs), Prilosec, Biotin, Forvia, Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa** ~Allergies - Singulair
~Secondary Reynauds Syndrome -'04 - Norvasc~Fibromyalgia -'06~No meds
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Veteran Member

Date Joined Jul 2007
Total Posts : 2148
   Posted 2/12/2008 10:24 AM (GMT -6)   
I take mine after dinner usually between 7 & 8 PM. I think I may have felt a little nauseaus at first not sure if that was b/c of when I took it and taking it on an empty stomach or b/c of my flare but after a few weeks I was fine.

Also the pred/azathioprine combo I think makes my head foggy, but I feel better going from 60/40 alt days to now just 40 a day of the pred.

Hope you are well soon!
Beth, 32
Major Flare Sept/Oct 07 ~ no blood since Dec 07 ~ almost normal bm
UC dx'd March 2000 (30 cenitmeters as of 2005-proctosigmoiditis)
Azathioprine 200mg 1xday nightly; Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Probiotics.
Minimal Change Disease (Kidney Disorder) dx'd Sept 2007
Prednisone 40mg 1xday, Simvastatin 20mg 1xday, Diovan 160mg 2xday. Tekturna 150mg 1xday, Fursomide 20mg 1xday.  Potassium 100mg 2xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.

Regular Member

Date Joined Feb 2008
Total Posts : 42
   Posted 2/12/2008 10:44 AM (GMT -6)   
Hi all
Just to say thankyou so much for replying and so soon !
I have just picked them up and was going to try them but will now wait till bedtime !
thankyou again for the help and support

Elite Member

Date Joined Mar 2003
Total Posts : 10407
   Posted 2/12/2008 6:11 PM (GMT -6)   
The Azathioprine never made me tired or nauseated. I took them in the morning with the rest of my bucket full of pills.
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Colazal,  Remicade, Nature's Way Primadophilus Reuteri.
In remission since April, 2006. Remicade has been my wonder drug.
Co-Moderator UC Forum

Regular Member

Date Joined Oct 2007
Total Posts : 320
   Posted 2/12/2008 6:25 PM (GMT -6)   
I'm on 100mg of 6-MP a day - 50mg morning and night. I don't get nausea, but if I come down with a cold or a cough, it leaves me feeling physically exhausted and I pretty much can't get out of bed.
"We are dreamers, shapers, singers and makers..." - Elric, Technomage
  • 28yo male, Australia. Diagnosed at 16yo;
    - 2xColazide, twice a day; 1x6-MP twice a day; 1xAbatacept 10mg/kg per month;
    - 1xZinc per day, 1xteaspoon of Metamucil smooth powder 3 times a day;
    - 1xBIOCeuticals UltraBiotic 45 per day + 1xSB FlorActiv per day;
    - 3xGarlic Oil caps 2 times a day, 5mL Olive Leaf Extract 2 times a day.

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