I'll try to give the Reader's Digest version....Hubby went into hospital 5/07 after a year of trying various things and it was at this point in time Imuran was started. And yes we were told 3-6 months to probably kick in so one month even though you are going through hell you need to hang in there as others are saying as well. However his Dr put him on 40 mg of prednisone to kick start the Imuran...that was mid May and he was confined to the house due to the urgency and frequency and pain and on July 3rd was the first time he felt comfortable enough to be able to go out in a social setting which was a major event for us.
He was started on a very low dose of 75 mg which was later changed to 150 mg (he weighed almost 200 lbs) and he is now off the prednisone totally and the imuran and asacol have him on a scale of 8 or 9 in comparison to the 0 he was at when admitted to the hospital that May.
Based on advice here we requested a change from the colocourt retention enemas that he just could not hold in for more than an hour or so and it was very uncomfortable - the cortifoam was so much easier to use and way more comfortable and did help.
It stinks that this is such a trial and error thing with the meds and finding what will help and work for you. Try to be patient and see it through - but you might need a higer dose of imuran with monitoring of blood work, maybe a higher prednisone dose to help the imuran with a tapering schedule.
My husband was at the point you could have just gone in there and ripped that colon out for all he cared. I have no experience with Remicade and many do on the board here who can give you advice but it still seems like the imuran is just not being given enugh time yet in your case along with some of the other suggestions mentioned.
Good Luck..............we feel your pain - we honestly do.
61 yr old male~Colitis 1st diagnosed Jan '05-cleared up within a few wks. Flared again in May '06 (now UC) & hospitalized 5/07-currently heading towards a remission. Osteopena of spine from prednisone DX 8/07 Oct 07 feeling quite normal most days. 150mg Imuran
Zero mg prednisone 12 Asacol, Lidocaine Hydrochloride Jelly 2%,multi vitamin, iron 1X day, DanActive, chewable calcium, fiber capsule 1x day, Prilosec 20mg, enalapril 10mg, glipizide 5 mg, zocor 40 mg, baby aspirin, (Fentanyl pain patch 50mg 72 hrs Morphine Sulf 15 mg twice daily)Cortifoam enema PM, Canasa suppositiry AM, folic acid 1mg, Fosamax 1x month