Why do you think you might have c-diff, Jeffrey? There's usually a course of antibiotic and/or exposure to an infected person that can be pointed to as causing c-diff. Without either of those, it's very unlikely that you have c-diff.
C-diff is pretty infrequent, really. I would imagine less than 1% of the population has ever had or will ever have c-diff. (That's just a guess, but . . .)
I believe that, yes, prednisone might slow down or diminish the symptoms of c-diff, but it will slow down or diminish the effects of any inflammation. Without a precursor, an inciting incident, if you will, I don't understand why you are suspecting c-diff.
Mitz (who had c-diff, and who had a nephew and an aunt who had c-diff)
Sporadic proctitis since about 1985. Mother had J-pouch surgery 1983.
DX'd with clostridium difficile in 2000. Pred, two courses of Flagyl, then Vancomycin finally got rid of it. 2001 colonoscopy dx'd left-sided UC. . Treated with prednisone, Rowasa, Asacol. Asacol not working, switched to Imuran. Three small flares since in 2002, 2005, and 2007, brought under control with steroid and Rowasa enemas. Lap Chole performed October 26, 2007, after gall bladder attack in June, '07.
Daily meds: 100 mg Azathioprine and 225 mg Effexor XR (for chronic, longstanding depression), many vitamins and Primadophilus Reuteri