azathioprine, imuran and 6-mp...which is better?

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Veteran Member

Date Joined Jul 2007
Total Posts : 2148
   Posted 2/18/2008 5:10 PM (GMT -6)   
I fear the azathioprine is not working for me.  I wonder if imuran or 6-mp would be possible alternatives or if aza is not working for me then the others wont either?  Are we on what we are on b/c of the way our bodies metabolize them?
Beth, 32
Major Flare Sept/Oct 07 ~ no blood since Dec 07 ~ almost normal bm
UC dx'd March 2000 (30 cenitmeters as of 2005-proctosigmoiditis)
Azathioprine 200mg 1xday nightly; Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Probiotics.
Minimal Change Disease (Kidney Disorder) dx'd Sept 2007
Prednisone 40mg 1xday, Simvastatin 20mg 1xday, Diovan 160mg 2xday. Tekturna 150mg 1xday, Fursomide 20mg 1xday.  Potassium 100mg 2xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.

Veteran Member

Date Joined Dec 2005
Total Posts : 3238
   Posted 2/18/2008 5:11 PM (GMT -6)   
As far as I know Aza is the generic for Imuran. I'm assuming you wouldn't see any difference there. I believe we have had members who have responded to Imuran better than 6mp or vice versa.
Tabitha (Tab)

100mg Azathioprine, 2 Fibercon, Colazal-9 a day, Acidopholis Pearls, Nexium
Co-Moderator UC Forum

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 2/19/2008 9:21 AM (GMT -6)   
When you first start taking either AZA or 6mp, you take the Prometheus test. This tests for certain levels in your blood and the doctor determines which one you should do better on. If for some reason you are unable to tolerate one, then the doc can change it over to the other unless there is a certain toxicity. AZA breaks down into 6mp in the liver so 6mp is the purer form so the liver doesn't have to work as hard to break it down. Some people need that break down in order to metabolize it correctly while others don't. I have been on 6mp now for 1 1/2 years and I first had the Prometheus test to determine which one would be better for me and it seems my doc put me on the right one. But I had to have dose increases because I wasn't metabolizing it properly.
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc -'92 - Colazal (9 daily), 6mp (50-100mgs), Prilosec, Biotin, Forvia, Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa** ~Allergies - Singulair
~Secondary Reynauds Syndrome -'04 - Norvasc~Fibromyalgia -'06~No meds
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