Definitely try lowering the amount you take. When I first started using Rowasa, it made me so ill with cramping and diarrhea that I couldn't leave the house. It did stop the bleeding though. I played with the dosage and after a full year found 1/2 bottle every other day does the trick for me. I have been doing that for over a year and I take 4 Colazal a day. I've been in remission since I figured this out (over a year).