Methotrexate and Ulcerative Colitis Question

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New Member

Date Joined Feb 2007
Total Posts : 17
   Posted 2/22/2008 4:46 PM (GMT -6)   
Hi All,
Has anyone had any unexplained tiredness while taking methotrexate?  I take it for arthritis pain associated with colitis. I also take folic acid which is supposed to lessen the side effects.  I take my dosage 5mg Sat morning, 5mg Sat even. and 5mg Sun. morning.  I've been taking the med for less than 2 months but I was wondering if it was working.  Any comments, advice?
medications- Pentasa 1gram 3times a day

Elite Member

Date Joined May 2003
Total Posts : 30835
   Posted 2/23/2008 3:26 AM (GMT -6)   
I've never been on it....have you discussed it with your doctor?

Have you had your thyroid and blood count done? Could you be anemic?

You take the 3 dosages once a week....are you tired ALL the time or just a short time afterward?

Is there any improvement throughout the week?

*Heather*Status: mini flare Dec 28... tapered to every 3rd night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....bromelain 1 - 2x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 2/23/2008 7:32 AM (GMT -6)   
You can try asking this question on the arthritis forum too if you haven't already done so. I'm not sure if many of us on here have ever tried MX.
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc -'92 - Colazal (9 daily), 6mp (50-100mgs), Prilosec, Biotin, Forvia, Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa** ~Allergies - Singulair
~Secondary Reynauds Syndrome -'04 - Norvasc~Fibromyalgia -'06~No meds
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Veteran Member

Date Joined Jan 2006
Total Posts : 616
   Posted 2/23/2008 11:17 AM (GMT -6)   
I take 7.5 mg every Friday night and definitely feel kind of drained on Saturday and sometimes sunday. I asked my aunt about this, cause she's on it too and she does not experience any fatigue related to hers.
So i asked my GI what he thought, and if I should maybe take the three pills spread out like you do, and he said that would probably just spread out the fatigue :P
Asacol 4 tabs 2x daily
Forvia once a day
Probiotic twice daily
Methotrexate 3 pills once a week
Actonel once a week
Calcium supp.
1 mg Folic Acid daily
Omega-3 once daily
12th Remicade infusion End of March

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