Remicade Reaction... Try Humira??

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Soph
New Member


Date Joined Mar 2006
Total Posts : 10
   Posted Today 7:09 PM (GMT -7)   
I just had my second Remicade infusion on Friday and sadly, had a reaction after 30 minutes of a very slow infusion. Initially, the palms of my hands and bottoms of my feet began itching, followed by red pinpoint spots all over my inner arms and tummy. Shortly after, the dots began growing together in welts (or hives) and I needed another IV injection of Benadryl (didn't help much) and Pred (helped a lot) to get the reaction under control. The doctor thinks I have a 'very strong immune system' and of course, we won't be able to continue with the Remi, which is depressing since it DID seem to help get my UC symptoms under control the first time and even this last time with just the 30 minute slow infusion, my UC symptoms have abated... for now.
 
I am very frustrated as we have gone through so many meds now, many that aren't working to keep me in any kind of remission at all since my 2004 diagnosis (Asacol, 6-MP, Endocort, Rowasa, still on Colazal), I am desperate to get off the Pred that I've been on for years now, up and down, up and down. So far, the Pred is the only med that really controls the UC. The side effects after this long of use are horrid, as many of you know.
 
On to my question:
 
I know Remicade is made with mouse-human molecule antibodies (20/80) and Humira is made with all human monoclonal antibodies. In light of the Remicade seeming to help my UC overall, I was wondering: has anyone had a reaction to the Remi but have had no reaction (and success treating the UC) with the Humira? How common is it to have a Remi reaction soley from the mouse Ab's? I know getting insurance to cover the Humira is tricky, but soley on the efficacy issue, I was wondering about your experiences.
 
Thanks!

Scrap Girl
Veteran Member


Date Joined Jan 2007
Total Posts : 653
   Posted Today 8:37 PM (GMT -7)   
Hopefully, someone will be able to answer your questions here but you might also try posting this on the Crohn's board since a lot of those people have used both. Good luck!
Diagnosed with UC in Feb. 2005
 
Colazal (9 a day)
Folic Acid
Biotin
Calcium
Remicade remission


princesscolon
Veteran Member


Date Joined Apr 2006
Total Posts : 733
   Posted Today 8:59 PM (GMT -7)   
There are some people on the Crohn's board who had the reaction with Remicade and are on Humira. I remember at least one person having sucess with Humira. I have been waiting to start Humira myself after having a delayed reaction to Remicade. I have been having a lot of trouble getting it because my insurance denied it for UC. I am concerned about having another reaction, but it's a risk I personally feel is worth taking. Plus I feel a little better about it knowing it's human proteins.
Diagnosed with Left-sided Ulcerative Colitis 1995 at 15, Tried: Prednisone, Rowasa & Hydrocort. Enemas, Proctofoam, Sulfasalazine, Asacol, Probiotics, Fish Oil, Canasa, Enotcort, Colazol, Anamantle, etc... had almost recto-vaginal fistula in 2004, put on Remicade, August 2007:Increased Remicade dosage-700mg every 6 weeks,diagnosed w/ Psoriatic Arthritis & Fibromyalgia Current meds: Remicade 700mgs every 6 wks (had reaction, will start Humira Feb 11) Clorazepate, Proctofoam HC, Glucosamine 500, Vitamin B, Lomotil,  Tylenol pm, Lyrica for Fibromyalgia started 1/17/08


blueclassring
Regular Member


Date Joined Feb 2007
Total Posts : 385
   Posted Today 9:30 PM (GMT -7)   
You are having an allergic reaction to the medication, probably due to the murine antibodies. While uncommon, it does occur in some patients. I think you're biggest problem is trying to the get Humira for UC. The insurance company will probably deny it because it doesn not have an FDA approval for it as of now. I am sad to see that you are running out of medication options. Have you tried the specific carbohydrate diet?
Pharmacy Student
Class of 2009, MWU

Diagnosed 8/99.  Suffered for almost 10 years.  I am currently on the Specific Carbohydrate Diet and am nearning remission.  I feel fantastic!  My next goal is to gain the 15 lbs I lost 6 weeks ago and start living life again.  I have lost so many years to this disease. 


I decided to become a pharmacist to understand these drugs, and to help fellow sufferers of IBD.  My goal is to open up a pharmacy and take care of my patients(particularly explaining what the drugs do to you), compound special medications, and have a great practice. 

3200 mg Asacol, 5 mg prednisone
HAVE YOU CONSIDERED THE SCD DIET? IT HAS PUT ME IN REMISSION AND I PLAN ON GETTING OFF THE ASACOL SOON TOO!


blueclassring
Regular Member


Date Joined Feb 2007
Total Posts : 385
   Posted Today 9:31 PM (GMT -7)   
Why do some meds work for some and not for others? Unfortunately, the medical/scientific community has a long way to understand our afflictions!!!
Pharmacy Student
Class of 2009, MWU

Diagnosed 8/99.  Suffered for almost 10 years.  I am currently on the Specific Carbohydrate Diet and am nearning remission.  I feel fantastic!  My next goal is to gain the 15 lbs I lost 6 weeks ago and start living life again.  I have lost so many years to this disease. 


I decided to become a pharmacist to understand these drugs, and to help fellow sufferers of IBD.  My goal is to open up a pharmacy and take care of my patients(particularly explaining what the drugs do to you), compound special medications, and have a great practice. 

3200 mg Asacol, 5 mg prednisone
HAVE YOU CONSIDERED THE SCD DIET? IT HAS PUT ME IN REMISSION AND I PLAN ON GETTING OFF THE ASACOL SOON TOO!


EricaM
Regular Member


Date Joined Jan 2007
Total Posts : 184
   Posted Today 11:15 PM (GMT -7)   
I had the same reaction to remicade....I had to take 20 mg of prednisone the night before for pretreatment, then the benedryl prior and during my infussion. They also had to have the IV drip real slow or else I would start to become ill. Most people would be in and out in 1 1/2 to 2 hours it would take me 4 1/2 to 5 hours. I did this for a little over a year.

Humira was going to be the nest step but everything is in remission right now (I have crohn's) and I have been off all medications since September.

Erica
Erica
Crohn's and Ostomy in 2004


johnh5703
New Member


Date Joined Mar 2008
Total Posts : 6
   Posted 3/3/2008 12:34 PM (GMT -7)   
I have been in a serious flare of UC (pancolitis) since Oct. 07. My GI doc put me on Humira (not any other biologic like Remicade) first. Started loading dose on Feb. 13, 08. Second dose just completed on Feb. 27, 08. Went from 10+ bms blood, etc. before first loading dose to 5-7 with no blood (3-4 of these are rapid fires in the morning until things are calmed down and cleared out). Very happy with results so far. My insurance covers Humira for UC even though its not FDA approved yet for UC. Study being completed April 08 that should allow Abbott, the pharmaceutical co, to get approval. My GI specifically did not want to try me on Remicade first because he was well aware of the mouse antibody issues. I have had no noticeable adverse events being on Humira so far. Make sure ahead of time that your insurance will cover the costs. You should also like the freedom of the self-administered shots.

Eva Lou
Veteran Member


Date Joined Sep 2006
Total Posts : 3437
   Posted 3/3/2008 1:03 PM (GMT -7)   
another note re. insurance coverage- my GI was telling me that managed care will cover Humira for UC if the patient is allergic to Remicade or Remicade fails the patient, ie- unable to induce remission. Go for it, I say!

diagnosed with UC '02
meds-
Asacol- 8 tabs/day
Remicade infusions
Imuran- 100mgs/day
Iron supplement
Culturelle
 

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