I emailed the manufacturer of PhosChol to get feedback on whether their product would be beneficial for treating UC and got the following reply:
To the best of our knowledge there have been a couple published papers using enteric PC capsules for colitis (one of which is attached). However, he uses a PC of low purification grade (with 30% PC only!) while the main components of phospholipids in mucus are phosphatidylcholine and lysophosphatidylcholine with up to 90%! Therefore, it's advisable to
administer PC as pure as possible. Furthermore, there are no data showing that you get more PC with that poorly purified released material to the colon than with pure PC (PhosChol). Even if most of the pure PC is absorbed in the upper GI-tract, a significant part remains for the lower part. At least, first publications with pure PC have shown a positive effect on
ulcerative colitis, too. And, two of these publications are even mentioned in the reference list of Stremmel's paper (nos. 16 and 17).
I mention all of the above regarding a purified preparation of PPC as we believe that there is no commercially available enteric coated capsule. Our understanding is that the product used in this study was provided especially for this study and that the authors and or partners of the authors are considering a use or product patent application for treating colitis with a slow release capsule. We have no additional information as to when or by whom such a capsule will be made available to the market.
We strongly suggest that you use PhosChol, Phosphaline (distributed by Xymogen) or Hepato Pro (distributed by Life Extension). Only these three products are 100 percent purified PPC and capable of delivering a therapeutic dose of 1,2 dilinoleoylphosphatidylcholine (DLPC). For this reason, any other non-purified phosphatidylcholine or triple strength
lecithin product is not recommended for acute or chronic conditions.
Rio, 31 yr old male - diagnosed with UC in 07/2006.
Alternative therapies for several months (SCD, ayurvedic treatment, VSL#3): didn't work and became anaemic. Canasa, 2 daily: remission for a month then flared-up.
07/07-11/07: 4800mg Asacol (6 x 400mg, twice a day) & Aloe Elite.
Completed first (6 week) tapered course of Pred in 10/07, flaring up since coming off it.
11/07: Switched from Asacol to 12 x 750mg Colazal (3 weeks on it and symptoms got worse)
12/07: Asacol 4800 mg, Started Azathioprene 175mg, Prednisone taper from 60mg - Now on alternate days of 20mg and 10mg; 2/08: added 1 Pentasa x 1mg.