Colazal has an enteric coating which makes it break down lower in the colon. Asacol needs a certain PH level to break down and therefore goes straight through the body without breaking down at all sometimes.
Asacol didn't work for me. Colazal caused cramping and diarrhea. Once I lowered the dose, those side affects stopped. I take 4 Colazal a day and 1/2 Rowasa every other day and have been in remission for over a year.
You should consider taking Rowasa if you don't already use it. It's a rectal med. that works incredibly well.
left-sided UC since 11/05
Rowasa, Colazal, Calcium, Centrum
Natren Healthy Trinity Probiotics