Posted 3/3/2008 12:17 AM (GMT -7)
I think they try the 6-MP/Imuran before Remicade for a few reasons. It's oral medication, so you can avoid infusions. It also works via a different mechanism--still immune suppressant, but different pathway, so it's worth a try. I've also been told that it's easier to stop taking 6MP in trying to taper off and stay in remission. My doc called Remicade a very long-term option. With my disease being steroid dependent, but mild to moderate, I think we're both still holding out hope that once I'm out of vet school things might get better.
Rachel

23 yrs old
Diagnosed with UC: March 2004 with probable IBS component

Currently taking:
Asacol 4pills 3x/day
Prograf 5mg/day
(Prograf is my miracle drug! It doesn't seem to be well known, but it's fantastic!)

Previously Tried:
Prednisone (works, but such awful side effects!), 6-MP (gave me acute pancreatitis), Entocort, Cipro (antibiotic), Bentyl, Canasa suppositories, a couple different enemas

Posted 3/3/2008 7:40 AM (GMT -7)
Thank you all for the advise. It is only 6:30 here in California. After a long and painful weekend I will be calling my GI as soon as they open. He discussed starting me on 6-MP, but I cannot imagine remaining like this for a few months until it kicks in. I will discuss Remicaid vs. Prednisone with him.  When I saw him last he seemed to want to go the 6-MP route instead of the prednisone. I hope he calls me back today. He sometimes calls back the next day. Pancolitis - dx December 2006 Colazal 750 mg - 9/day (generic) Canasa 1000mg 1/day (???) Women's One-A-Day Multi-Vitamin Calcium +D 500 mg - 3/day Coumadin 2.5 mg/day (for DVT, dx 2/13/07) Asacol (bad reaction); mesalamine supp. (bad reaction); Seasonale (birth control); cranberry pill - 300 mg  3x/day (urinary tract infec.) ; Lovenox injec. 2x/day (for DVT); Prednisone - 10 mg/day; Folic Acid - 400 mcg x2/day
Posted 3/3/2008 7:43 AM (GMT -7)
Hey Legalsec, I'm in Sacramento, California...yep it's early! :-) Hope your doc gets back to you asap; no need for you to be feeling poorly.

Carol

Remicade - will have my 21th infusion on April 17.
Vitamin B-12/Biotin, Probiotics
 
Co-Moderator for the UC Forum
 
 

Posted 3/3/2008 8:01 AM (GMT -7)
Just remember that quality of life for a person with rhuemetoid arthritis is very different than quality of life for a UC patient. Just like some asthma patients and organ transplant patients, prednisone is a needed drug for quality of life. However, for a UC patient some of these drugs aren't needed long term for quality of life. I am very glad that I never had the opportunity to take Remicade for UC and that I ended the battle on 6mp.

Sue
dx proctitis in 1987
dx UC in 1991, was stable until 1998

1998 started prednisone, asacol, pentasa, nortriptylene, ativan, 6MP, rowasa enemas and suppositories, hydrocortisone enemas, tried the SCD diet, being a vegetarian, omega 3s, flax, pranic healing, yoga, acupuncture, probiotics

2000 lost all my B-12 stores and became anemic

2001 opted for j-pouch surgery- now living life med-free

Posted 3/3/2008 8:41 PM (GMT -7)
I saw my GI today. He had me do more labs and a C-Diff. He wants me to start back on prednisone, but wants me hold off for 48 hours until he gets the results of my C-Diff.  He said he will start me on 6-MP next week when all my lab results are back. He wants me to start the prednisone at 60mg for one week then taper down to 40 mg. When I was on prednisone before I tapered by 10 mg each week. Is it okay to go from 60 mg to 40 mg? If I had minimal side effects from the prednisone last time, will it be the same this time around? The only side effects I noticed were night sweats and I had to take benadryl to be able to get 3 hours of sleep. I tapered down without any withdrawls that I noticed. I pray that the 6-MP will put me back in remission and I have no side effects from either the 6-MP or the prednisone.  Thank you all for your input and listening! Pancolitis - dx December 2006 Colazal 750 mg - 9/day (generic) Canasa 1000mg 1/day (???) Women's One-A-Day Multi-Vitamin Calcium +D 500 mg - 3/day Coumadin 2.5 mg/day (for DVT, dx 2/13/07) Asacol (bad reaction); mesalamine supp. (bad reaction); Seasonale (birth control); cranberry pill - 300 mg  3x/day (urinary tract infec.) ; Lovenox injec. 2x/day (for DVT); Prednisone - 10 mg/day; Folic Acid - 400 mcg x2/day
Posted 3/4/2008 7:08 AM (GMT -7)
Yes, a taper from 60mg to 40mg is safe. It's only when you get to the lower numbers that it gets dicey.

Sue
dx proctitis in 1987
dx UC in 1991, was stable until 1998

1998 started prednisone, asacol, pentasa, nortriptylene, ativan, 6MP, rowasa enemas and suppositories, hydrocortisone enemas, tried the SCD diet, being a vegetarian, omega 3s, flax, pranic healing, yoga, acupuncture, probiotics

2000 lost all my B-12 stores and became anemic

2001 opted for j-pouch surgery- now living life med-free

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