I have a client/friend who is on it at this time because of idopathic anaphylaxis. To my embarassment, I was unexpectedly shocked when I saw her because it's changed her physically and emotionally to the extreme. It didn't help her as much as intended. It's cost her dearly, but her dignity remains steadfast and I admire her greatly.
Considering the alternative without it...it's hard to justify it one way or the other.
Personally....regarding UC....I'd have my colon removed before I went on that stuff. THAT is NO word of a lie.