Methotrexate Anyone?

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Regular Member

Date Joined Apr 2006
Total Posts : 172
   Posted 3/8/2008 8:35 AM (GMT -6)   
Has anybody here tried a drug called Methotrexate.

I think its a immunosuppressent thats used after intolerance to imuran.

Is it effective, Is it worth a try?


Elite Member

Date Joined Mar 2003
Total Posts : 10407
   Posted 3/8/2008 10:10 AM (GMT -6)   
Good morning, Gargamel. I don't know anyone who has used it for UC, but I do know it is used to treat certain cancers, rheumatoid arthritis, psoriasis and sometimes Crohn's. It works by suppressing the fast-growing cells in your body, i.e. skin cells, bone marrow, cancer cells. My experience with it was largely with cancer. I know it can also have some nasty side effects, which I'm sure you've already looked up.

Also, MTX is a very potent cause of serious birth defects if either parent is taking it when a pregnancy is conceived, so you have to use effective birth control while on it.

This link provides a little more information about MTX and other drugs we sometimes take:

I did a little searching and did find a study from the UK showing that it may be effective:

Hope this is helpful to you.

Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Colazal,  Remicade, Nature's Way Primadophilus Reuteri.
In remission since April, 2006. Remicade has been my wonder drug.
Co-Moderator UC Forum

Post Edited (Judilyn) : 3/8/2008 8:19:54 AM (GMT-7)

Veteran Member

Date Joined Jan 2006
Total Posts : 616
   Posted 3/8/2008 11:13 AM (GMT -6)   
I take it, but with Remicade to help prevent antibodies.
Asacol 4 tabs 2x daily
Forvia once a day
Probiotic twice daily
Methotrexate 3 pills once a week
Actonel once a week
Calcium supp.
1 mg Folic Acid daily
Omega-3 once daily
12th Remicade infusion End of March

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