Mercaptopurine?!

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ColitisIsTheWorst
Regular Member


Date Joined Mar 2008
Total Posts : 36
   Posted 3/8/2008 11:39 PM (GMT -6)   
Hi, i am currently considering taking this drug and would love to hear other's thoughts/ experiences.

Here's my History: I am a 29 year old women. I was diagnosed with Ulcerative Proctisis in November of 2007 and was treated with Canasa until June of 2007. During that time I had three flair-ups, two of which my former doctor treated with 3 weeks of prednisone. I then switched to Asacol, beginning at a lower dosage and finally moving to 4 pills 4 x a day. Since June, I have had three flair-ups, two of which my former doctor treated with steroids. I then switched doctors in January, and am currently having a flair-up that my doctor is treating with steroids, rowasa and the continuation of my asacol. My new doctor is suggesting a much more aggressive approach, and wants be to consider using Mercaptopurine. Experiences? Thoughts?
Thanks!

Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 23551
   Posted 3/9/2008 6:37 AM (GMT -6)   
Have you considered using the steroid enemas instead of the Rowasa? Do you still have UP or has it spread?

I have left sided Uc and I was running into the problem that the oral med wasn't reaching a certain area and the rectal meds were only treating so high up. It was that in between area that was giving me the most trouble so after flaring pretty bad for a year and being on steroid enemas off and on, my doc finally put me on 6mp (mercaptopurine). I've been on it now for 1 1/2 years and my flares have finally ended - I still get them, but not as severe and they are more easily treatable now. This drug can take anywhere from 3 months to a year to start working depending on the severity of a flare and how fast your body responds to it. I started having an improvement of symptoms at 7 weeks but at 3 months I felt like a switch was thrown. That is when I knew the 6mp truly kicked in for me. There are side effects when you first start this med. Such as fatigue, headaches, nausea and mild hair loss. I found that by taking it at night, it helped majorly with the fatigue and headaches. I only had mild nausea and very mild hair loss. It took about a month or so for my body to become accustomed to the med.

Oh and welcome to Healingwell! :)
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Allergies-Singulair
~Secondary Reynauds Syndrome-'04-Norvasc~Fibromyalgia-'06~Sacroiliitis-epidural injections
To help Healingwell - click here: DONATE
 
 
 
 

 
 


ColitisIsTheWorst
Regular Member


Date Joined Mar 2008
Total Posts : 36
   Posted 3/9/2008 11:38 AM (GMT -6)   
Thanks for the thorough response! My original doctor diagnosed me as having UP, but it is right in the border zone and a few doctors who have looked at my chart said that they would have labeled it Colitis and treated me more aggressively.
I used colocort (steroid enema) in August and liked it, but my new doctor thinks that prednisone (40 mg), Rowasa at night and Canasa during the day is a better combo. Truth, I have no idea, but this flair sucks.
Thanks for the welcome, it feels good to have found a place where people are dealing with this as well.

blueclassring
Regular Member


Date Joined Feb 2007
Total Posts : 385
   Posted 3/9/2008 1:49 PM (GMT -6)   

have you considered alternative treatments like changing your diet?

 


Pharmacy Student, Class of 2009.  Diagnosed 8/99.  Suffered for almost 10 years.  I am currently on the Specific Carbohydrate Diet and am nearing remission.  I feel fantastic!    I have lost so many years to this disease.  I decided to become a pharmacist to understand these drugs, and to help fellow sufferers of IBD.  My goal is to open up a pharmacy and take care of my patients(particularly explaining what the drugs do to you), compound special medications, and have a great practice. HAVE YOU CONSIDERED THE SCD DIET? IT HAS PUT ME IN REMISSION AND I PLAN ON GETTING OFF THE ASACOL SOON TOO!  (In remission since 2/15/08)
Meds 3200 mg Asacol, 2.5 mg Prednisone.  Doc wanted to put me on 6-mp or Remicade, but I refused to take the medications!  For me, diet works...


ColitisIsTheWorst
Regular Member


Date Joined Mar 2008
Total Posts : 36
   Posted 3/9/2008 4:18 PM (GMT -6)   
Yes, I've been on the blandest of diets pretty consistently from the beginning, and i do accupuncture for the pain. When i'm flairing, I basically eat chicken, baked potatoes, soy mac and cheese, and drink ensure. When I'm not flairing, i eat more stuff liked well cooked veggies, beef and fish, but still avoid dairy and anything raw, except sushi which my doc actually recommended. I've pretty muc h put together this diet by trial and error, so any suggestions would be much appreciated.
Oh, and I started VSL #3 about a month ago, i'm waiting on those amazing results...
Lb

ColitisIsTheWorst
Regular Member


Date Joined Mar 2008
Total Posts : 36
   Posted 3/10/2008 9:45 AM (GMT -6)   
Hey Red_34, One more question, how bad is the hair loss? I already have some from the strain of Colitis, and i am trying not to be vain, but its hard...
Thanks! LB
Asacol, 4 pills 4 X a Day
Rowasa at Night
Canasa in the Day
Prednisone 40 mg--I'm flairing right now.
VSL #3
Kariva (birth control)


suebear
Forum Moderator


Date Joined Feb 2006
Total Posts : 5698
   Posted 3/10/2008 10:11 AM (GMT -6)   
I took mercaptapurine (6MP) for 1.5 years to try to get off prednisone. I had no side effects from the medication.

Sue
dx proctitis in 1987
dx UC in 1991, was stable until 1998

1998 started prednisone, asacol, pentasa, nortriptylene, ativan, 6MP, rowasa enemas and suppositories, hydrocortisone enemas, tried the SCD diet, being a vegetarian, omega 3s, flax, pranic healing, yoga, acupuncture, probiotics

2000 lost all my B-12 stores and became anemic

2001 opted for j-pouch surgery- now living life med-free


Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 23551
   Posted 3/10/2008 11:30 AM (GMT -6)   
My hair is thick anyway - think Q-tip - skinny body and puffy head! :) So I didn't mind losing some hair. It wasn't that bad really and soon as my body got used to it, the hair loss stopped. One thing that you can take to help battle the hair loss is Biotin. Biotin is naturally produced in the intestines and if one has chronic D then it can deplete that causing hair loss. I had deep ridges in my nails so I started taking Biotin and within 6 months the ridges were gone and my hair became super healthy. I started at 3mgs but it didn't do anything so I've been on 5mgs for about 2 years.
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Allergies-Singulair
~Secondary Reynauds Syndrome-'04-Norvasc~Fibromyalgia-'06~Sacroiliitis-epidural injections
To help Healingwell - click here: DONATE
 
 
 
 

 
 


dakotagirl
Veteran Member


Date Joined Apr 2006
Total Posts : 3402
   Posted 3/10/2008 12:13 PM (GMT -6)   
The hair loss I had with Imuran wasn't any worse than that I experienced with prednisone. I used Biotin for a while and the hair grew back fast.
Pan-colitis and GERD diagnosed May 2003
 
Asacol 12 per day,  Azathioprine 75mg, Aciphex, Effexor XR, Forvia and a Probiotic
Osteopenia (hip and spine) from prednisone use.  Started Azathioprine because I was steroid dependent.
 
Co-Mod for the UC forum
Keep HealingWell running smoothly:  www.healingwell.com/donate


redbull
Regular Member


Date Joined Mar 2008
Total Posts : 30
   Posted 3/10/2008 6:54 PM (GMT -6)   
Hi! I have been taking 100 mg of mercaptopuine for about 4 years had no side affects,still have to take prednisone guite often for flair ups. The doc wants to up the mg because of to many flairups and mentioned remecade.

ColitisIsTheWorst
Regular Member


Date Joined Mar 2008
Total Posts : 36
   Posted 3/12/2008 9:19 PM (GMT -6)   
Thanks for the responses everyone--definitely helped me go into my doc's office prepared. I'm gonna do it--praying on that miracle cure! Thank you, discovering healingwell is definitely making this flair a bit more bearable...
Lb
Asacol, 4 pills 4 X a Day
Rowasa at Night
Canasa in the Day
Prednisone 40 mg--I'm flairing right now.
VSL #3
Kariva (birth control)

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