I'm not knocking Remicade, Loneylane, don't get me wrong- it gave me at least a year of relative comfort. I do not however think it's the miracle drug of UC's future. I just don't think the biologics are where the "cure", if there is any, lies. That said, I'm not going to sugarcoat my experiences with it- bottom line, it stopped working, whether due to my body building antibodies to it, or just myself having refractive UC. And if you look on the ostomy forum, there are many, many, MANY people who were on Remicade for ages, & boom, it just stopped working. It doesn't seem to be all that uncommon. As far as being on the Remicade still- I had an infusion March 3rd, the double dose. It is my last one, in all likelihood. I will be going for surgery early May, & the surgeons do not like you to have Remicade in your body, if possible, as it impedes healing. Even now, it does make me feel better- prior to the infusion on the 3rd, I had been symptomatic for about 2 weeks. It helps, but only for a few weeks.