intolerance to 5-ASAs. How do you know?

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Veteran Member

Date Joined May 2007
Total Posts : 528
   Posted 3/15/2008 3:55 PM (GMT -6)   
Hey. I was on Asacol, but switched to Colazal about 2 months ago because it was making me very nauseous. For awhile I was feeling much better, but now my stomach is acting strange again. Nauseous, lessened appetite, gas, etc.... not my UC because no bleeding or diarhea, etc.... feeling very good actually, except for this nauseous, which seems reminiscent of right before I got off Asacol. Are Asacol and Colazal made of the same thing? could I be intoleranet to all 5-ASAs? thanks.
Pancolitis dx 3/07
9 Colazal a day (was on 12 Asacol/day, but suddenly got sick from it)
150mg Imuran/day (steroid dependent, reached this dose 9/07)
Cortfoam in AM, Rowasa in PM (is working wonders for me thus far)
Various vitamins, bit of fish oil, a probiotic.
Getting married October, 2008!!!!

Regular Member

Date Joined Jul 2007
Total Posts : 402
   Posted 3/15/2008 7:35 PM (GMT -6)   
I believe that Asacol and Colazol are both mesalamine medications. So is Rowasa, though. Does that seem to bother you as well?
Proud new mom of a beautiful baby boy!
Current Medications:
- Asacol (4 pills, 3x per day)
- Rowasa (1 enema daily, as needed)
- Folic Acid (1 mg, 1x per day)
- Calcium (600 mg, 2x per day)
- Prenatal Vitamin (1x per day)

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 3/16/2008 7:22 AM (GMT -6)   
Asacol and Colazal are both 5-ASA's however Asacol is mesalamine and Colazal is Bazalazide. Colazal has a different delivery system and breaks down differently in the colon then Asacol does. I never started getting stomach pain with Colazal until a year or so ago (after being on it for 2 years). I believe the switch from Asacol to Colazal damage my stomach lining in which I have to take a PPI now because if I don't I get severe stomach pain and nausea. You should discuss this with your doctor to be on the safe side.
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Allergies-Singulair
~Secondary Reynauds Syndrome-'04-Norvasc~Fibromyalgia-'06~Sacroiliitis-epidural injections
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Regular Member

Date Joined Oct 2006
Total Posts : 90
   Posted 3/16/2008 8:51 AM (GMT -6)   
I'm sure the more veteran members can better answer your question. I can't take Asacol either. When I had my first severe flare, my GI upped my Asacol dose to 12 pills the day. The more I took the worse my symptoms became. It was horrible. I was much better once I stopped the Asacol and just used prednisone to get my flare under control. Since then, I've switched to Colazal. MY GI told me it that it was the same as Asacol, but it breaks down differently in your colon and some people can tolerate one but not the other. I did try Lilada too, which is basically Asacol in one dose and I had the same reaction as I did to Asacol. It's really hard and frustrating when some of these medications give us the same side effects we are trying to combat.
Diagnosed UC - 1993
32 year old female

Current Meds:
Prednisone - 40 Mgs
6-MP - 50 Mgs
Colazal (3 pills three times a day)
Probiotic, Folic Acid, Lysine

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