Prdenisolone Side Effects - Dosage Related?

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Schmoner
Regular Member


Date Joined Apr 2007
Total Posts : 26
   Posted 3/18/2008 12:45 AM (GMT -6)   
Hi Folks,
 
Just a quickie.....
 
In a flare - again! Seems like as business as usual lately.....
 
Are side effects to Pred dose related?
For example, struggling to get lower than 10/5mg - if I was to remain on this dosage for a while longer, would to moonace and other nasty effects start to dissappear as it's such a low dose, or do you need to get off the drug completely?
 
Also, is there such a thing as a Prednisolone Enema, and has anyone had any experience with it?
 
Thanks everyone
 
Craig
Diagnosed with UC March 2007 - Proctitis
 
Currently Taking:
 
Asacol 3 Tabs (400) x 3 Daily
Prednisolone 40mg 35mg 30mg 25mg 20mg 15mg 10mg 5mg 2.5mg Daily 
Iron Supplement 200mg 1 Daily
Omeprazole 20mg (Acid)
Awaiting Start of Azathioprine Trial
Various Asthma Medications (List too long)
Calcium supplements 400mg twice daily
Multivitamins + Minerals once daily


Asia
Regular Member


Date Joined Aug 2005
Total Posts : 188
   Posted 3/18/2008 2:10 AM (GMT -6)   
I'm not too sure about that. I think if you were on a low dose for a long period of time that you would have some minor side effects.

I've had Cortenema, which are prednisone. There weren't too many side effects for me. Acne and fatigue. They made my bum happy though!
Diagnosed with UC in August 2005. 
Suffered for my whole life before being diagnosed. 
Told to "Eat more fibre." 
 
Currently on:

Salofalk 1500mg x 4/day
Entocort
6mg x 1/day
Entocort increased to:
9mg x 3/day as of 2.14.08


Schmoner
Regular Member


Date Joined Apr 2007
Total Posts : 26
   Posted 3/18/2008 12:09 PM (GMT -6)   
Bump
Diagnosed with UC March 2007 - Proctitis
 
Currently Taking:
 
Asacol 3 Tabs (400) x 3 Daily
Prednisolone 40mg 35mg 30mg 25mg 20mg 15mg 10mg 5mg 2.5mg Daily 
Iron Supplement 200mg 1 Daily
Omeprazole 20mg (Acid)
Awaiting Start of Azathioprine Trial
Various Asthma Medications (List too long)
Calcium supplements 400mg twice daily
Multivitamins + Minerals once daily


dakotagirl
Veteran Member


Date Joined Apr 2006
Total Posts : 3402
   Posted 3/18/2008 2:03 PM (GMT -6)   
I had my worst issues once I got below 20mg. From experience, it seems that each time you are on pred, you need to be on longer or at a higher dose. But, that could be my steroid dependency talking.

It took a few weeks AFTER I was off of the pred for my side effects to START to disappear. However, my last pred stint was about nine months long :(

There are steroid enemas. You may still have side effects, but since your body is actually absorbing less of the drug, it takes longer for them to develop and they may not be as severe.
Pan-colitis and GERD diagnosed May 2003
Osteopenia diagnosed Feb 2006
 
Asacol 12 per day,  Azathioprine 75mg, Aciphex, Effexor XR, Forvia and a Probiotic
 
Co-Mod for the UC forum:  Keep HealingWell running smoothly:  www.healingwell.com/donate


Beth75
Veteran Member


Date Joined Jul 2007
Total Posts : 2148
   Posted 3/18/2008 2:46 PM (GMT -6)   
hey there.  I also post at a Kidney board and I wanted to know if being on a low dose 5mg for a year after being on 60mg a day for 7 months would I lose the moon face etc.  A response that I got was for that person it took a couple of months being on the low dose and their moonface etc. started to go away.  Everyone is different, I hope for both of us that will be the case.

Beth, 32 ~ Major Flare Sept/Oct 07 ~ almost in remission
UC dx'd March 2000 (30 cenitmeters as of 2005-proctosigmoiditis)
Azathioprine 200mg 1xday nightly; Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Prilosec, Probiotics.
Minimal Change Disease (Kidney Disorder) dx'd Sept 2007 - partial remission since 03/08
Prednisone 40mg 1xday (taper 5mg a week = ), Simvastatin 20mg 1xday, Diovan 160mg 2xday. Tekturna 300mg 1xday, Fursomide 20mg 1xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.
Pre-Diabetic from Prednisone use - Low carb/sugar diet & exercise.


jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10407
   Posted 3/18/2008 3:26 PM (GMT -6)   
From my observations, steroid side effects seem to vary from person to person. Some will get them on lower dosages, others of us never get the moon face. I think it's hard for anyone to propose a timetable for that reason. I do know the longer you're on them the more slowly you have to taper and the more time it takes for the temporary side effects to go away.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Colazal,  Remicade, Nature's Way Primadophilus Reuteri.
In remission since April, 2006. Remicade has been my wonder drug.
 
Co-Moderator UC Forum


sjkly
Veteran Member


Date Joined Dec 2007
Total Posts : 2113
   Posted 3/18/2008 3:54 PM (GMT -6)   
Hmm...keep in mind that though similar prednisone and prednisolone are different drugs and have somewhat different side effect and dosage profiles. Prednisolone is an immediate acting corticosteroid-in my experience the side effects are dosage dependent and as you come down in dose some of the side effects will go away.

barnsbury
Regular Member


Date Joined Jan 2006
Total Posts : 467
   Posted 3/19/2008 10:52 AM (GMT -6)   

Craig

If you had a big moonface while on >20mg Pred then being at 5mg - yes, it would start to disappear. But, VERY slowly.  Once you have been on such a low dose for around 2/3 months, it will be mostly gone, but you still wont have your old face back exactly as it was.  But, it will be very minor.

BTW, when you are tapering from 5mg, I would suggest going down in 1/2 mg increments every 2/3 weeks. Sounds silly, but it makes a huge difference. I have been on pred for many years now and have learnt the hard way. Im down to 3mg.

Good luck


Abatacept Trial since Feb 2008 (Induction Period)
Back on Pred - 5mg - Steroid Dependent :-(
Azathioprine 175mg
Colazide x3
Actonel 35mg
Predfoam Enema - Had to stop as not allowed during trial
EPA Fish Oils, Various Homeopathic meds
Asacol x 9, Lialda (Mezavant)
Remicade every 8 weeks  (Stopped working)
Aloe Vera Lily of the Desert Juice  Gave me the worst D !
Primadophilus Reuteri Probiotic
 

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