can you go off 6mp?

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Regular Member

Date Joined Nov 2007
Total Posts : 395
   Posted 3/26/2008 7:21 AM (GMT -6)   
my daughter was put on 6mp along with everything else listed below. she was not responding
to the other meds. since the 6mp and the rifaxamin were started together and she responded very soon after '
i believe it was the antibiotc that did it since 6mp takes a long time to kick in. it's now about 1 1/2 months but she
responded in about a week. the dr. would like her to stay on both thought i don't yet know how long she intends to keep her on the rifaxamin the
6mp is supposed to be pemanent. but i'm wondering if you go off of it can you use it again -or is it one of the drufgs you build up immunity to?
i don't want to change anything while she is away at school, but i'm wondering about this when the semester ends late may. can you use 6mp every other day?
Mom to 19 year old daughter diagnosed 11/07.
asacol 2 3x daily-discontinued
colazal 3 3x daily/switched to 4 4x daily
proctofoam 3x daily/1-2xdaily
mesalamine enema 1x daily
canasa suppostiories 3x daily /switched to court supp 1-2x daily
culturelle probiotic 1 daily
chewable vitamin
hydrocortisone enema at bed time 6mp50
xifaxan antibiotic 400mg 2x day

Veteran Member

Date Joined Feb 2005
Total Posts : 6448
   Posted 3/26/2008 8:35 AM (GMT -6)   
I would think since it takes so long to build up in your system and takes a while for the system to respond to it that it wouldn't be a good idea to get off of it; do you have a plan intact with her doctor? And I think it's probably best to ask your doc about the 6mp every other day; maybe not the best thing to self medicate, although I admit to doing it from time to time!


Remicade - will have my 21st infusion on April 17.
Vitamin B-12/Biotin, Probiotics
Co-Moderator for the UC Forum

Veteran Member

Date Joined Aug 2007
Total Posts : 2204
   Posted 3/26/2008 9:04 AM (GMT -6)   
Seems like someone told me if I quit taking 6mp, I wouldn't be able to take it again, but I don't know if that's really true or was just a scare tactic. This is certainly something you need to discuss with your doctor. Also, I would NOT self-medicate or change dosage without your doctor's consent on steroids or immunosuppresants.
Diagnosed with ulcerative colitis spring 1999.
Therapeutic dose sulfasalazine.
Probiotics, l-glutamine and fish oil caps. George's aloe vera juice and Mucosaheal. Oregano oil antibiotic, antiviral, antifungal.

Veteran Member

Date Joined Feb 2005
Total Posts : 6448
   Posted 3/26/2008 9:14 AM (GMT -6)   
Yes, I should say that I never self medicate with prescription meds.


Remicade - will have my 21st infusion on April 17.
Vitamin B-12/Biotin, Probiotics
Co-Moderator for the UC Forum

Veteran Member

Date Joined Jul 2007
Total Posts : 2148
   Posted 3/26/2008 9:59 AM (GMT -6)   

My GI told me that it does not take 3-6 months to kick in unless you start at a very small dose and work your way up to it.  (just repeating what I was told about azathioprine, which I believe is close to 6mp). 

I started azathioprine/cipro/hydrocortisone e's at the same time and in a couple of weeks I had great improvement........don't know which is responsible, but I have since stopped the e's. 

IMO - (based on thinking the anitbiotic is not a maintenance drug) We all need to be on some kind maintenance drug to reduce flares and symptoms.  I would be leery of reducing or discontinuning the 6MP, since she is doing well or at least give her some more time of feeling well before changing, it would be terrible for her if she went through another flare again so soon.

I know some do not agree w/me, but that is my 2 cents.

Beth, 32 ~ Major Flare Sept/Oct 07 ~ almost in remission
UC dx'd March 2000 (30 cenitmeters as of 2005-proctosigmoiditis)
Azathioprine 200mg 1xday nightly; Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Prilosec, Probiotics.
Minimal Change Disease (Kidney Disorder) dx'd Sept 2007 - partial remission since 03/08
Prednisone 30mg 1xday (taper 5mg a week from 60 = ), Simvastatin 20mg 1xday, Diovan 160mg 2xday. Tekturna 300mg 1xday, Fursomide 20mg 1xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.
Pre-Diabetic from Prednisone use - Low carb/sugar diet & exercise.

Old Hat
Veteran Member

Date Joined Feb 2007
Total Posts : 5187
   Posted 3/26/2008 11:09 AM (GMT -6)   
Hopefully you'll hear from Keith (KS1905) on this because he can advise you from personal experience, + he consults with an excellent IBD gastro affiliated with Mt. Sinai Hospital in NYC. / Old Hat (nearly 30 yrs with left-sided UC ... [etc.])
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