Lialda - Side effects

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New Member

Date Joined Mar 2008
Total Posts : 1
   Posted 3/28/2008 4:14 AM (GMT -7)   
Hello all! I'm new to this forum. I was diagnosed with micro-UC in 2003. My flare ups are probably not nearly as bad as what most of you folks experience. I have a GI and have been on sulfasalazine for roughly two years, but have been incredibly bad about taking my meds. I'm not sure what is considered a flare up, but having blood in my stool and regular diarrhea has been a part of my life. I personally consider a flare up for myself when I have abdominal crapming, extreme fatigue, and other symptoms. My last big flare up was a little over year ago when it was so bad I had to go to the ER. They diagnosed me with diverticulitis, but my GI later dismissed that. Now, I am going through a pretty bad flareup -- shortness of breath, incredibly painful abdominal pains (mostly left side, but a little on the right as well), etc. So I went to my GI and he put me on Lialda. I was pretty excited to get a med that i only had to take once a day. He has me taking 4 pills a day. I'm on my second day. So far it's incredibly hard for me to determine if the symptoms I am having now are caused by the Lialda or if the UC is just getting worse. These symptoms include what appears to be more intense cramping/abdominal pains, more shortness of breath, feeling nauseous, feeling feverish, and most importantly intense constipation. I'm going to call my GI first thing in the AM tomorrow. I figured while I can't sleep I might as well see if other folks have had similar experiences.

Also, everything i have read says stress can't cause UC, but I can't help but to feel like it's intensely related. Everytime I have a flareup I am usually going through some serious stress. Is it possible for stress to bring UC out of remission?



Veteran Member

Date Joined Mar 2008
Total Posts : 678
   Posted 3/28/2008 7:23 AM (GMT -7)   
I could not tolerate Lialda. It made my symptoms much worse. I had terrible stomach cramps, increase in D and bloody D - which I didn't have prior to taking Lialda.
Diagnosed 2/29/08 with Mild Universal UC
I've had UC since 2000 but was in remission for most of those 8 years med free
Lialda & Asacol made symptoms worse
Trying Colazal next...

New Member

Date Joined Mar 2008
Total Posts : 16
   Posted 3/28/2008 10:30 AM (GMT -7)   

Hi Dan,

I also take 4 Lialda a day. I'm currently tapering off of prednisone (I'm almost down to 20 mg). The only side effect I have from the Lialda (or possibly the prednisone) is severe constipation. I also have heartburn and bloating. I told my GI, but she just said I probably have a case of IBS now (she's not the best GI around). She did say to take Colace stool softeners or Miralax, in addition to magnesium suppplements for the constipation. I'm new to UC treatment so I maybe other members have more knowledge about Lialda. I have to say that my meds (prednisone and Lialda) worked immediately. I was symptom free in 7 days and continue be symptom free 6 weeks later. Hope this helps.


4 Lialda/day
30 mg Prednisone
SCD Diet 2 months
Assorted probiotics 7/day
Assorted vitamins

Regular Member

Date Joined Apr 2007
Total Posts : 116
   Posted 3/28/2008 10:56 AM (GMT -7)   
I have been on Lialda for about a year and I don't have any side effects. I have found it to be pretty effective. I am currently in a flare, but it was brought on by a bout of food poisoning. One thing to note is that I needed a long course of prednisone to get into remission, but once I was there Lialda kept me healthy for a long time.
-currently having a flare
-prednisone , rowasa enema, Lialda (4 pills 1 time a day), canasa, probiotic, multivitamin, calcium with vitamin d, iron

Veteran Member

Date Joined May 2006
Total Posts : 619
   Posted 3/29/2008 1:54 PM (GMT -7)   
While stress doesn't CAUSE UC, it certainly does aggravate it if you have it, and yes, it can bring on flares, you're not imagining things. I'd give the Lialda a few more days then call your GI if your symptoms are still not improving.

What are you eating now? Stay away from "gassy" veggies, like broccoli, cabbage, peppers. Rice is usually "safe" for most of us, seafood, especially salmon, is a good protein source, most find avocado soothing. Everybody finds different things help or hinder, but those are almost universal. Avoid fibrous veggies, seeds, popcorn, that sort of stuff. Most people find coffee, decaf or regular, not manageable when in a flare.
Diagnosed UC April 27, 2006
Remicade infusions: 7/21/07; 8/18/07; 10/13/07; 12/15/97; 1/26/08; 3/8/08
Lialda, 4 tabs in the morning; Protonix; Prednisone 4/27/06-present, tapering attempt, down to 10/5 mg. alternating daily. Daily supplements: multivitamin w/folate; Culturelle; Fish oil capsules, calcium chews and/or Tums
12/1 - 12/29/07 weekly Venofer (iron) injections; <S>9 mg Entocourt EC</S>; Xanax as needed; Lexipro 10 mg, <S>Rowesa;</S> <S>Asacol; Colazal</S>; Bad reactions: Imuran (2/07)

Regular Member

Date Joined Oct 2007
Total Posts : 348
   Posted 3/29/2008 3:51 PM (GMT -7)   
EllieKate, I also experienced heartburn while on the prednisone.........Once I stopped the Pred, the heartburn also stopped.

Dan, are you on any rectal meds like Rowasa? They also can be very helpful.. And yes, stress definitely aggravates the UC.
diagnosed with uc 27 years ago.  Enojoyed 10 - 12 year remission (approximately 10 of those years without any meds)
currently on Sulfasalazine 2 tabs 3x day. Folic acid, mesalamine enema every 4th night, will try to spread it out more. Omega 3, Probiotics, multi vitamin, cacium supplement, Biotin....
In remission since Jan 2008, can't believe it.............

New Member

Date Joined Mar 2009
Total Posts : 7
   Posted 3/25/2009 6:20 PM (GMT -7)   
l have been on 3 Lialda a day since summer of 2006, I thought for a very long time that it was the best thing ever happened. So few pills, so little medicine to think of and remember. but suddenly the late fall 2008, sever chest muscle pain, shoulder pain, elbows and hands constantly hurting. i felt destroyed. not only do I have the UC but now it was like my body hated me in every way. i could not even lift a tetra of juice or milk out of the refrigerator. very well, when i finally told my doctor that this was going on, he told me this is a side effect of Lialda. after 3 days on replacement medicine, I'm like new again. happy happy happy pain free!

Sulfasalazine 3 tabs x 2 day, D-vitamin, calcium

New Member

Date Joined Jul 2010
Total Posts : 2
   Posted 7/28/2010 11:13 AM (GMT -7)   
I was put on Lialda two weeks ago, and since my symptoms have only gotten much, much worse. I asked and was given Prednisone, as that's the only thing I've found that has worked, but I'm having to take twice the dosage I was prescribed to relieve any symptoms. For two days I've been taking both the Lialda and Prednisone, but I think I will stop taking the Lialda and see how I fare. I definitely don't want to keep being sick at the level I am now.

Regular Member

Date Joined Dec 2004
Total Posts : 64
   Posted 7/29/2010 11:22 AM (GMT -7)   
I was on Lialda the past year and it worked GREAT for me. Unfortunately, my liver enzymes have been creeping up over the last several months and a liver biopsy showed inflammation. My GI thinks it is PSC. But when I mentioned the lialda and we looked up my history, he goes lets change your medication. So I am on Asacol HD 2 @ 3x Daily and Rowasa enemas Nightly. Doctor is leaving the DX as PSC while we keep an eye on it.
Male, 29 Years Old
Diagnosed 1999: Moderate Pancolitis
Meds: Lialda - 4.8g Daily
Status: Good - 2 -3 urges a day

New Member

Date Joined Oct 2011
Total Posts : 7
   Posted 10/25/2011 8:39 PM (GMT -7)   
According to the Lialda flier I picked up in the waiting room at my GI (Flier from the manufactures of Lialda) Drugs containing mesalamine including Lialda can cause a syndrome that's symptoms are indistinguishable from Ulcerative Colitis. It did not name the syndrome and I have not found the name of it. But it seems insane to me to treat a disease with a drug who's side effect is the exact symptoms of the disease it is supposed to treat. That said I am getting back to life after a bad flare and am currently on Lialda and a Prednesone taper. Thanks to previous posts I now know why I have heart burn.

Forum Moderator

Date Joined Jun 2011
Total Posts : 3316
   Posted 10/26/2011 4:59 AM (GMT -7)   
I've been on Lialda for over 2 years and don't have an side effects. When I was on 4 pills though I didn't take them all at once. Two in am and two in pm and always after eating if you feel sick from it.
Diagnosed April 2009

Currently taking Lialda 2 tabs in am, Protonix 40mg every day, Xyazal, Probiotics, and Rowasa enema every 3rd night

Regular Member

Date Joined Sep 2011
Total Posts : 62
   Posted 10/26/2011 5:17 AM (GMT -7)   
I just started taking Lialada after taking Apriso for over a year. I am just getting over a really HORRIBLE flare and asked my GI about switching maintenance drugs to see if a different brand might work better for me. I'm not sure if those side effects would be from Lialada...I think it takes a while for these pills to truly start working in your 6 wks or something. I am also on Prednisone at the moment, 50mg, and can't wait to be finished with them. When I first started taking the Pred it did give me the absolute WORST heartburn!!! Might be starting on 6MP soon - meeting a GI tomorrow that my current GI wants me to discuss with him for a second opinion.
34 year old female
Diagnosed with Left-Sided Ulcerative Colitis 8/10 - changed to Pancolitis 10/11
Was taking Apriso, now switched to Lialada (4 pills, once a day)
Currently on 50mg of Prednisone for flare which started 9/11
GI thinking of starting me on Imuran soon
Taking probiotics, tumeric, calcium, vit c, multi-vit, fish-oil
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