My husband said the same thing about
"Do you wish you married someone else" or "if I want to trade for a better model " etc. He feels guilty because we got married in April 07, didn't go on a honeymoon because he spent the day after the wedding curled up in a ball on the couch in pain. His flare started as soon as he moved into our new house in Feb 07 and UC basically ruined our first year of marriage. He ended up breaking his arm because of water retention in his legs and the high dose of prednisone. I had to help him up the stairs every night and put his shoes on (he's 28). He ended up on disability because he was too sick to work or do any chores. He was so depressed.
I would think it is completely normal to feel down about this disease. Our light at the end of the tunnel came when he had to have his colon removed in emergency surgery because it was about to perforate.