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New Member

Date Joined Mar 2008
Total Posts : 7
   Posted 3/29/2008 5:40 PM (GMT -6)   
I was just wondering if anyone else is on Methotrexate. its not fda approved for colitis, but is for chrons. My doctor said that they've been having some success with it for UC though. I was on 6mp but got severly sick after a week. The enzyme thats supposed to help your body with the medication was extremely low, so i cant go back on that... Prednisone works but as soon as i taper off it i flare again. this disease is so frustrating. I only got diagnosed a year ago and it feels like this whole year has been one big flare. Anyway.. Monday will be my 9th injection of Methotrexate. I still feel like im not getting any better. I still have abdominal craping.. urgency... blood in my stools.. and im still going to the bathroom what feels like a gazillion times a day. Does anyone know if its supposed to be taking this long to work or if it even does? Also im thinking about remicade or even surgery. Does anyone have any tips, stories, or facts about any of these. i need all the help i can get right now!
Current Meds: Lialda- 2 pill twice a day
                    Cortocol enemas- 1 at night
                    Methotrexate- 1cc injection once a week
                    Lexapro- 10mg
tried- Asacol, Colazol, 6mp, Prednisone

Julia Hill
Veteran Member

Date Joined Mar 2008
Total Posts : 562
   Posted 3/29/2008 8:14 PM (GMT -6)   
It is to bad you are still having so many symptoms. I have had crohn's for 27 years, and I to am on MTX. I had weekly injections for 25 weeks before I started remicade, but I will say that the MTX was helping, it just took awhile. Does it upset your stomach? Have you tried imodium for the diarrhea? Take care and I hope your symptoms improve soon.

Veteran Member

Date Joined May 2007
Total Posts : 528
   Posted 3/29/2008 9:11 PM (GMT -6)   
my GI recently told me that Methotrexate is not nearly as effective in UC as in Crohns.
My understanding is that remicade has better potential in UC, and also, potentially, fewer side effects.
it sounds like you are still having a lot of symptoms, so maybe time to think about remicade? just a thought.
feel better soon.
Pancolitis dx 3/07
9 Colazal a day (was on 12 Asacol/day, but suddenly got sick from it)
150mg Imuran/day (steroid dependent, reached this dose 9/07)
Cortfoam in AM, Rowasa in PM (is working wonders for me thus far)
Various vitamins, bit of fish oil, a probiotic.
Getting married October, 2008!!!!

Veteran Member

Date Joined Jan 2006
Total Posts : 616
   Posted 3/29/2008 11:51 PM (GMT -6)   
I'm on the pill form of methotrexate, but in combination with remicade. With me it is being used to help reduce the chance of building antibodies to the remicade. I didn't start the methotrexate until after I'd been on remicade for a while. I don't notice any difference with it. I only take 7.5 mg one night a week.
I hope you get some relief soon, perhaps it is time for some remicade for you.
Asacol 4 tabs 2x daily
Forvia once a day
Probiotic twice daily
Methotrexate 3 pills once a week
Actonel once a week
Calcium supp.
1 mg Folic Acid daily
Omega-3 once daily
12th Remicade infusion End of March

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