Tapering Prednisone

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Regular Member

Date Joined Feb 2007
Total Posts : 30
   Posted 3/30/2008 3:38 PM (GMT -6)   
My GI started me back on prednisone on 3/6/08 at 60 mg due to a bad flareup. It took a while to kick in. My first good day was 3/24/08, without cramping, less diarrhea and very little blood. Before this I was going 15-20 times a day with lots of pain, blood and mucous. For the past 6 days I go 4-7 times with only sometimes that I see blood. I was also started on 6-MP on 3/17/08, which I know takes a while to start working.  I hate being on prednisone again. At this stage is it too soon to start tapering down the prednisone? I am hoping to stay on prednisone for a short course, but I don't want to set things back by tapering too soon.

Pancolitis - dx December 2006: 6-MP (started 3/17/08); Prednisone 60 mg(started again 3/6/08); Colazal 750 mg - 9/day (generic); Canasa 1000mg 2/day; Women's One-A-Day Multi-Vitamin; Calcium +D 500 mg - 3/day; Coumadin 2.5 mg/day (for DVT, dx 2/13/07); Folic Acid - 400 mcg x2/day

Asacol & mesalamine enemas (bad reaction); Seasonale (birth control) caused DVT; cranberry pill - 300 mg  3x/day (urinary tract infec.) can't take with Coumadin;

Lovenox injec. 2x/day (for DVT)

Elite Member

Date Joined Mar 2003
Total Posts : 10407
   Posted 3/30/2008 4:09 PM (GMT -6)   
I think most sources say 6-MP takes at least six weeks to take effect. Given that, I'd wait at least 6 weeks, then taper very slowly.
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Colazal,  Remicade, Nature's Way Primadophilus Reuteri.
In remission since April, 2006. Remicade has been my wonder drug.
Co-Moderator UC Forum

Regular Member

Date Joined Mar 2008
Total Posts : 113
   Posted 3/31/2008 8:27 AM (GMT -6)   
My doc told me last week that 6MP takes 3-4 months to start working!

New Member

Date Joined Mar 2008
Total Posts : 2
   Posted 3/31/2008 2:56 PM (GMT -6)   

When I was on 6-mp, my consultant said the medication would take 12 weeks to work, I was also on a high dosage of prednisone. He said I would not be able to reduce my steriod intake until after being on the 6mp for 12 weeks. However I did not manage to stay on the 6-mp due to abnornal blood tests. Hope this helps a bit.

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