I went off my Asacol because I lost them (It's a long story). The pharmacy couldn't refill my prescript
ion for 30 days so I had to go without. I did great for 3 weeks and then the symptoms started to creep back in. I called the Dr. for some samples until my 30 days were up and could get the pills refilled. As soon as I resumed the Asacol, I did OK again. I'm stayin' on them. They're gold.