I think you do have to wait a bit before starting Humira. What does his GI say? Did the doctor suggest the Humira? It seems a little soon to assume that the Remicade has lost effectiveness, but then again, if he's on the highest dose with no improvement, I guess you'd have to assume that. I'm trying to remember what it was like for me...I think the remicade is helping a little, but who knows. I'm currently 5 weeks out from my last high-dose infusion, which is when things start to go bad usually. We'll see. I hope your son finds some relief with Humira- I know you've been crazy with worry. Unfortunately though, when you do some research, it appears that for the people who have lost responsiveness to Remicade, the same thing occurs with Humira pretty quick. Some people on here have just started on Humira after Remciade, so I look forward to hearing their results.