Humira after Remicade

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Regular Member

Date Joined Mar 2007
Total Posts : 111
   Posted 4/4/2008 6:38 PM (GMT -6)   
It looks as if since the Remicade has lost its effectiveness, the next route is Humira.  Does anyone know if we have to wait until the Remicade is out of his system (he just had an infusion on Tuesday) before we can start humira?  Thanks!  And has anyone heard of a drug called Tysabri?
Mother of 18 year old son
6MP 100mg

Veteran Member

Date Joined Apr 2006
Total Posts : 733
   Posted 4/4/2008 8:10 PM (GMT -6)   
I had a reaction to Remicade and my GI scheduled my Humira to start 6 weeks after the Remicade but then my insurance wouldn't approve it and I am taking it for "Psoriatic Arthritis." I just got the infusion yesterday and I have some welts but that's all so far and no diarrhea yet. I have heard a little about Tysabri but heard a few people died from it from what I have read, I think I have heard of it on the Crohn's board.
Diagnosed with Left-sided UC in 1995 at age 15, Prednisone, Rowasa & Hydrocort. Enemas, Proctofoam, Sulfasalazine, Asacol, Probiotics, Fish Oil, Aloe Juice, Canasa, Enotcort, Colazol, Anamantle, Remicade, etc... had 1 inch deep rectal ulcer 2004, put on Remicade, August 2007:Increased Remicade dosage-700mg every 6 weeks,diagnosed w/ Psoriatic Arthritis & Fibromyalgia Current meds: Clorazepate, Lomotil,  Tylenol pm, Lyrica started 1/17/08, Flagyl 750 mgs started 4/2/08, Humira started 4/4/08

Elite Member

Date Joined Mar 2003
Total Posts : 10407
   Posted 4/4/2008 10:24 PM (GMT -6)   
My GI's group is participating in clinical testing of Tysabri. The GI nurses at the infusion center said it's being seen now as a last resort drug for Crohn's. It has been associated with leukodystrophy, a degenerative and fatal brain disease. They said they don't think it's being considered for UC because we do have the option of surgery, so the risk isn't felt to be justified for UC patients.
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
Co-Moderator UC Forum
The information I share on this forum is based only on my own experience and study. It is important to consult your health care provider when making health-related decisions.

Eva Lou
Veteran Member

Date Joined Sep 2006
Total Posts : 3442
   Posted 4/5/2008 7:02 AM (GMT -6)   

I think you do have to wait a bit before starting Humira. What does his GI say? Did the doctor suggest the Humira? It seems a little soon to assume that the Remicade has lost effectiveness, but then again, if he's on the highest dose with no improvement, I guess you'd have to assume that. I'm trying to remember what it was like for me...I think the remicade is helping a little, but who knows. I'm currently 5 weeks out from my last high-dose infusion, which is when things start to go bad usually. We'll see. I hope your son finds some relief with Humira- I know you've been crazy with worry. Unfortunately though, when you do some research, it appears that for the people who have lost responsiveness to  Remicade, the same thing occurs with Humira pretty quick. Some people on here have just started on Humira after Remciade, so I look forward to hearing their results.

diagnosed with UC '02
Asacol- 8 tabs/day
Remicade infusions
Imuran- 100mgs/day

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