I just started Humira. I don't know the stats but it has been used for a while for RA and Crohn's so at least it's not like it has not been used ever before. I would be more weary about
Tysabri, I personally don't know if I would risk trying it, I have found some scary things about
it on the net. Give the Humira a chance. Don't forget to ice the injection spots beforehand and to leave the needles out 1-2 hours before injecting to prevent a rash (which I still have since Thursday). There have been recent studies that show that starting with more aggresive meds usually has a better result for UC than trying all the stuff that usually doesn't work very well. So maybe that is why the doctor wants him on such aggresive treatment. When you say that you are not sure it's worth it for the risks, I don't understand if he is considering surgery or what else you are considering... I hope the Humira works for him.