Posted 4/10/2008 8:25 AM (GMT -7)
I had red patches all over my arms and my lips were super puffy
Sam
19 years old
Diagnosed March 2005
Remission since January/April 2006 (incident with mono)
3200mg Asacol, 25mg Amitriptlyine, Ortho Tri-cyclen lo, Imodium when I need it
"If you don't like something, change it. If you can't change it, change your attitude"
Maya Angelou

Posted 4/10/2008 8:33 AM (GMT -7)
I have been on Sulfasalazine since I was first diagnosed over 30 years ago. I take 4 tablets twice a day. I have noticed that taking the entabs (time released coated tablets) work better for me that the regular ones. Fortunately, I have had no allergic reactions. I used to have a maintenance dose of 2 tablets twice a day, but now have noticed that when I go below a daily total of 8 I begin to flare.

M
Diagnosed UC 1975. 
Azulfidine Entabs 500 mg. 4 twice a day
Azathioprine 100 mg per day
Colocort - as needed
Folic acid, vitamins C and D, multivitamin, metamucil, fish oil, turmeric 
 
Hospitalized 1997 - intravenous cyclosporine.

Posted 4/10/2008 8:32 PM (GMT -7)
I am also on a maintenance dose of sulfasalazine (4 per day). I've had UC since 1980 - fortunately with very long remissions and fairly mild flares since the first couple years I was diagnosed.

I started reading here recently after having had three mild flares since the fall due to work-related stress. Usually bumping up my dosage is enough to control a flare.

I don't find that it helps my arthritis all that much, but maybe a higher dosage would. I was interested to read that others have experienced depression and headaches. Curiously, I did develop a sulfites sensitivity several years ago. I have always wondered whether that might be related to this med . . .

Boy, do I have a lot of questions to ask my GE the next time I see him for a colonoscopy!
Posted 4/11/2008 12:38 AM (GMT -7)
Im on the 3000mg diet of sulfasalazine a day (6pills). It works well but gives me migraines once every few months.
Posted 4/11/2008 3:01 AM (GMT -7)
Moo,

Sulfasalazine and sulfites are two different substances. While it is possible for there to be a connection (they're both sulfur containing substances), it is more likely something else caused your sulfite sensitivity. Vitamin B12, magnesium, zinc, iron, and molybdenum are nutrients that are needed to offset the sulfite sensitivity (these nutrients help the enzyme that processes sulfites to work better). Taking these nutrients should increase the amount of sulfite you can tolerate before experiencing a reaction - IF the problem is due to a deficiency in the sulfite processing enzyme activity. Vitamin B12 also directly binds to sulfites, rendering them harmless to the body, so if you do get exposed to sulfites accidentally, you can take oral Vitamin B12 to reduce the symptoms of the sulfite reaction. IF you are allergic to sulfites, the nutrients should still help, but won't help as much.
I happen to also be allergic to sulfasalazine and have sulfite sensitivity, but I tend to not do well with anything that contains sulfur (this is not the norm for people with sulfite sensitivity - usually, sulfa-drug allergy and sulfite sensitivity don't occur together).

Take care,


-Razzle
Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD (Lupus?), Osteoporosis, Anemia, T- & B-Cell Lymphopenia, malabsorption/malnutrition, Lyme Disease (Igenex Lab IgM WesternBlot positive/CDC negative), etc.
Meds:  Pulmicort, Injectable Vitamin B12, Herbs, Nutritional Supplements, Homeopathy.

Post Edited (Razzle) : 4/11/2008 4:04:23 AM (GMT-6)

Posted 4/11/2008 7:10 AM (GMT -7)
I have been on it for over twenty years. very cheap and it works.  Tried it when first diagnosed  and I had head aches, went off it tried again no problems. Currently 3 500 mg. 2 x a day, I self adjust as needed up or down.
Posted 4/11/2008 7:21 AM (GMT -7)
I'm also on sulfasalazine, by request. My first GI had me on asacol, which did not help and I believe made my D worse. I'm currently on a maintenance dose of 1 500mg tab, four times a day. When I'm flaring, which isn't very often, I take 2 tabs four times a day.

Diagnosed with ulcerative colitis spring 1999.
 
Maintenance dose sulfasalazine.
Probiotics, l-glutamine and fish oil caps. George's aloe vera juice. Oregano oil antibiotic, antiviral, antifungal.
 
 

Posted 4/12/2008 10:21 PM (GMT -7)
Razzle said...
Moo,

Sulfasalazine and sulfites are two different substances. While it is possible for there to be a connection (they're both sulfur containing substances), it is more likely something else caused your sulfite sensitivity. Vitamin B12, magnesium, zinc, iron, and molybdenum are nutrients that are needed to offset the sulfite sensitivity (these nutrients help the enzyme that processes sulfites to work better). Taking these nutrients should increase the amount of sulfite you can tolerate before experiencing a reaction - IF the problem is due to a deficiency in the sulfite processing enzyme activity. Vitamin B12 also directly binds to sulfites, rendering them harmless to the body, so if you do get exposed to sulfites accidentally, you can take oral Vitamin B12 to reduce the symptoms of the sulfite reaction. IF you are allergic to sulfites, the nutrients should still help, but won't help as much.

I happen to also be allergic to sulfasalazine and have sulfite sensitivity, but I tend to not do well with anything that contains sulfur (this is not the norm for people with sulfite sensitivity - usually, sulfa-drug allergy and sulfite sensitivity don't occur together).


Take care,

I'm aware they're not the same substance. But I have often wondered about the sulfur connection.

Coincidentally, I just bought some sublingual B12/folic acid to try to see if it might help boost my energy level. I need to also find a good multi-vitamin with minerals that I can tolerate.

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