Prometheus IBD test?

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UC Dude
Regular Member

Date Joined Aug 2005
Total Posts : 438
   Posted 4/11/2008 5:07 PM (GMT -6)   
Recently had a scope. Ten years since last one... colon looked bad and GI thought it looked more like Crohn's. Biopsies however were inconclusive. Did the blood work for the Prometheus test today. We shall see what that shows.

I really don't care "what" I have. More interested as it relates to approved meds. GI and Rheumy wanted me to go with Humira post scope... We shall see what the Ins co says..

Anyone get a positive dx with the special blood test?

Eva Lou
Veteran Member

Date Joined Sep 2006
Total Posts : 3442
   Posted 4/11/2008 5:20 PM (GMT -6)   
I didn't think that test had any diagnostic value??? I was under the impression the Prometheus tests were to see how your body metabolzied either 6MP or imuran.  That's what I had them for, at least. Also, Prometheus is a lab in California, not the name of the test itself. So maybe your GI did some sort of diagnostic test using Prometheus labs?

diagnosed with UC '02
Asacol- 8 tabs/day
Remicade infusions
Imuran- 100mgs/day
surgery scheduled 5/7/08- perm ileo

Regular Member

Date Joined Dec 2007
Total Posts : 354
   Posted 4/11/2008 5:48 PM (GMT -6)   
I noticed today that Prometheus name was on my Entorcort bottle today - I wonder if they distrubuted the drug. I did I blood test for P-A-N-C-A and something else but I don't know if it was the prometheus test or not. My doctor said that one was for UC and one was Crohns and they were fairly accurate but I tested negative for both.
Jessica 26/F
Asacol 4pills /three times a day(from 2 pills/ three times a day)
Culturelle once daily
Tried (Entorcort EC 9ml/day and Prednisone)

Veteran Member

Date Joined Aug 2007
Total Posts : 4415
   Posted 4/11/2008 6:39 PM (GMT -6)   
Prometheus is a company that distributes Entocort EC. Prometheus also has a laboratory that can test for the enzyme needed to metabolize 6MP/Azathioprine and for toxicity of metabolites of 6MP/Azathioprine. And they also have an IBD test panel that was developed initially to help physicians determine whether someone has UC or Crohn's when biopsies/other tests are inconclusive, but now is being used to diagnose people with IBD when other tests are inconclusive (misuse of the test? possibly, but I'm not an expert on this).

Take care,
Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD (Lupus?), Osteoporosis, Anemia, T- & B-Cell Lymphopenia, malabsorption/malnutrition, Lyme Disease (Igenex Lab IgM WesternBlot positive/CDC negative), etc.
Meds:  Pulmicort, Injectable Vitamin B12, Herbs, Nutritional Supplements, Homeopathy.

New Member

Date Joined Feb 2008
Total Posts : 18
   Posted 4/11/2008 8:42 PM (GMT -6)   
My daughter had this test done before diagnosis with UC. It was the serology 7 test by Prometheus. 
The test is supposed to tell you if your pattern is consistent with IBD. Hailey's came back negative even thought she was diagnosed with UC. Guess it's not perfect.
Mom to Hailey(age 9)....she was diagnosed with ulcerative colitis mid Feb 2008
Currently on 500mg pentasa 3x/day, 15mg prednisolone 2x/day (currently tapering), iron, and 25mg 6mp 1x/day which was started Mar 6th
As of April 2, taking flagyl and florastor for c-diff

Veteran Member

Date Joined Feb 2006
Total Posts : 5698
   Posted 4/11/2008 9:08 PM (GMT -6)   

And one should never rely soley on the results of a Prometheus test to determine whether or not they have Crohn's or UC.  These tests are far from definitive and should only be used as one part of the IBD jigsaw puzzle.


dx proctitis in 1987
dx UC in 1991, was stable until 1998

1998 started prednisone, asacol, pentasa, nortriptylene, ativan, 6MP, rowasa enemas and suppositories, hydrocortisone enemas, tried the SCD diet, being a vegetarian, omega 3s, flax, pranic healing, yoga, acupuncture, probiotics

2000 lost all my B-12 stores and became anemic

2001 opted for j-pouch surgery- now living life med-free

Regular Member

Date Joined Apr 2008
Total Posts : 163
   Posted 4/11/2008 10:01 PM (GMT -6)   
I've had two of the Prometheus tests, and they have come back both ways: one predicting UC, the other predicting Crohns. I just had a consultation with the physician/researcher who developed the Prometheus test (to tweak my meds), and I told him about the conflicting test results and asked him to clarify my diagnosis. He didn't hesitate in saying that I definitely have Crohns, based on the results of my last colonoscopy. So clearly the tests are less than perfect.
Dx Mild Proctitis 7/06 at age 33, Dx Severe Pan Colitis 5/07, Dx Crohn's Colitis 10/07
Failed Asacol, Lialda, 6-MP, Canasa, Rowasa, Entocort, and Remicade
On Humira since 1/08 with promising results, but can't get below 5mg Prednisone
Take Tylenol #3 as needed when not in close proximity to a bathroom.
Currently on 40mg Prednisone again since mid-March flare, ack
4/9/08 Humira dose increased to 40mg/week, Start slow Pred taper

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