Remicade/6mp combination?

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~ChristieAnn67~
Regular Member


Date Joined Dec 2007
Total Posts : 151
   Posted Today 10:52 PM (GMT -6)   
I have a question for you all.   Is there anyone else that is on both Remicade and 6mp?  I wonder now,  because I had read somewhere that being on both of those at the same time causes a higher risk of lymphoma and that there Dr took them off the 6mp.   Anyone else heard that?  Should I be off the 6mp while on Remi??  Its really been bothering me since I read it...what ya think?
                                          ~Christie
41 yo RN, happily married, with 2 beautiful daughters, Tianna(14 yo) and Alyssa(10 yo).   Diagnosed L sided Ulcerative Colitis in Jan '04 and Diabetes type 2 in June '05.
                                         Medications
Remicade infusions ~ 11/6/07, 12/6/07, 12/20/07, 2/14/08,  6-MP 100mg daily, Pentasa 500mg twice a day, prednisone 20mg 10mg 5mg daily, Nexium 40mg twice a day, Lantus insulin 45 35 25 20 units daily, Novolog 10 8 5 units with sliding scale at meals, Amaryl 2mg daily, multi-vitamin daily, Calcium daily, B complex vit daily,  and pro-biotics daily.


Severin
Regular Member


Date Joined Oct 2007
Total Posts : 320
   Posted 4/19/2008 5:26 AM (GMT -6)   
No - with regard to infliximab (marketed as Remicade), it is often best to be on a fully primed dose of 6-mp as well (meaning that you were on the 6-mp for at least a couple of months before starting infliximab).

The idea behind this is to stop the body reacting negatively to the infliximab via the production of antibodies.

Infliximab is a "chimeric monoclonal antibody". This means that the drug is constructed using both human and mouse components. As such, the body "can" react extremely badly to it, and builds antibodies (and as such a resistance) to it faster then if it were a purely human monoclonal antibody such as the drug adalimumab (marketed as Humira).

As for the lymphoma thing, to my knowledge, there is little evidence that Remicade or 6mp increase the chances of this by any sizeable percentage.

In the end, it comes down to you. Do you want to live 60 years and enjoy maximum quality of life, or do you want to live 100 years chained to the nearest toilet?
"We are dreamers, shapers, singers and makers..." - Elric, Technomage
  • 28yo male, Australia. Diagnosed at 16yo;
    - 2xColazide, twice a day; 25mg of 6-MP a day; 1xAllopurnol;
    - 1xteaspoon of Metamucil 3 times a day;
    - 1xBIOCeuticals UltraBiotic 45 per day + 1xSB FlorActiv per day.


Eva Lou
Veteran Member


Date Joined Sep 2006
Total Posts : 3442
   Posted 4/19/2008 6:36 AM (GMT -6)   
ditto what Severin says-- My GI always told me that being in 6MP/Imuran along with Remicade is pratically a "must", as the immune modulators prevent you from making antibodies to the Remicade. In theory, at least! The lymphoma risk is increased when you are taking both drugs at the same time, but again it's a very small %, mainly male pediatric patients.

diagnosed with UC '02
meds-
Asacol- 8 tabs/day
Remicade infusions
Imuran- 100mgs/day
Culturelle
 
 
 
 


kb5
Veteran Member


Date Joined Jan 2007
Total Posts : 1015
   Posted 4/19/2008 7:22 AM (GMT -6)   
My GI said the lymphoma risk was extrememly small. I was worried at first but I trust my GI.
Kelly, 30

Left sided UC diagnosed 1/98 age 19, Pan colitis diagnosed 1/07
Currently on 4x3 Asacol, 5mg pred, 150mg Imuran
Prontonix once daily for acid reflux, zofran twice daily for nausea, darvocet for pain
Remicade started 3/1/08...just had 3rd infusion


GardenerJames
Veteran Member


Date Joined Jan 2006
Total Posts : 616
   Posted 4/19/2008 8:37 AM (GMT -6)   
The lymphoma risk is extremely small, however all the people that got it were on Remicade and azathioprine. My GI stopped my Azathioprine cold turkey and switched me to a very small dose of methotrexate to ward off antibodies to the Remicade. I noticed no difference when I switched. He also pointed out that the azathioprine wasn't working for me anyway, otherwise I wouldn't be on Remicade.
James
Asacol 4 tabs 2x daily www.myspace.com/gardenerjames
Forvia once a day - Probiotic twice daily - Methotrexate 3 pills once a week - Actonel once a week
Calcium supp. - 1 mg Folic Acid daily - Omega-3 once daily
13th Remicade infusion End of April


jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10407
   Posted 4/19/2008 1:45 PM (GMT -6)   
My GI also stopped the Azathioprine when this study came out, and I never noticed any change in my symptoms. That was almost a year ago.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
Co-Moderator UC Forum
The information I share on this forum is based only on my own experience and study. It is important to consult your health care provider when making health-related decisions.


Meesh
Veteran Member


Date Joined May 2006
Total Posts : 619
   Posted 4/19/2008 6:08 PM (GMT -6)   
I couldn't tolerate Azathioprine (Imuran) within two weeks of being put on it. I have NEVER felt that awful. That was Feb 2007, my GI didn't try me on Remicade until July 2007 and it's made quite a difference, although I wasn't able to successfully taper off the Prednisone until I added Culturelle to my regimen and increased the frequency of the Remicade infusions to every six weeks.

I've read here about quite a few people being taken off Azathioprine while on Remicade due to lymphoma risk.

Meesh
Diagnosed UC April 27, 2006
7 Remicade infusions: 7/21/07; 8/18/07; 10/13/07; 12/15/97; 1/26/08; 3/8/08; 4/19/08
Lialda, 4 tabs in the morning; Protonix; Lexipro 10 mg; Prednisone 4/27/06-present, tapering now, alternating 5/0 mg. daily. Xanax as needed. Daily supplements: multivitamin w/folate; Culturelle; Fish oil capsules, calcium chews and/or Tums; 12/1 - 12/29/07 weekly Venofer (iron) injections; Off of the following:Entocourt EC; Rowesa; Asacol; Colazal; Imuran (extremely bad reaction 2/07)

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