My 4th Abatacept Trial Infusion

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barnsbury
Regular Member


Date Joined Jan 2006
Total Posts : 479
   Posted 4/19/2008 7:50 AM (GMT -6)   
Hello all
 
Last week was my 4th Abatacept infusion and the last in the induction period.  My sigmoidoscopy is scheduled for May 9th - and I will learn then If I have responded well enough to go into Stage 2 of the trial - 12 month maintenance.
 
At this stage I still don't know if I am on placebo or not. 
 
It has been 2 months since I began the trial, and I would say I have definately seen some improvement.  No D, and hardly any bleeding or cramping.  BUT, I still have urgency, and I have around 4 BMs a day (down from 7).  This to me is not remission, as I tend to recall feeling a lot better when I was last in remission - though it was many moons ago, lol.
 
I feel able to discontinue my prednisolone - but this is not allowed for at least another 4 weeks.
 
There must be at least 30% improvement in my colon when they check on May 9, and despite my improvement, I cannot be sure what they will find...
 
In summary then - and although it is very early days - I think Abatacept DOES alleviate symptoms to a degree and DOES allow steroid-dependent UC sufferers (like myself) to come off steroids, which is great.  However, it doesn't seem to induce a complete remission.  But, if I can come off steroids, and continue without worsening of my present symptoms, then I would be happy.
 
I will report back after my scope!
 
Take care
Abatacept Trial since Feb 2008 (Induction Period)
Back on Pred - 3mg - Steroid Dependent :-(
Azathioprine 175mg
Colazide x3
Actonel 35mg, EPA Fish Oils
Predfoam Enema - Had to stop as not allowed during trial
Asacol x 9, Lialda (Mezavant)
Remicade every 8 weeks  (Stopped working)
Aloe Vera Lily of the Desert Juice  Gave me the worst D !
Primadophilus Reuteri Probiotic
 


quincy
Elite Member


Date Joined May 2003
Total Posts : 30976
   Posted 4/19/2008 12:54 PM (GMT -6)   
Wow...you've definitely been through the med regimens....hope that if you're NOT on the abadacept you'll have the option once the trial is over...at least to give it a proper trial for youreself.

Thanks for the update.....

quincy
*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


Severin
Regular Member


Date Joined Oct 2007
Total Posts : 320
   Posted 4/21/2008 4:59 AM (GMT -6)   
KSU - I'd definantly agree with your conclusions. Abatacept doesn't seem to push one into remission, but it does seem to help quite a bit.
"We are dreamers, shapers, singers and makers..." - Elric, Technomage
  • 28yo male, Australia. Diagnosed at 16yo. Currently enjoying severe pan-colitis.
    - 2xColazide, twice a day; 25mg of 6-MP a day; 1xAllopurnol;
    - 1xteaspoon of Metamucil 3 times a day;
    - 1xBIOCeuticals UltraBiotic 45 per day + 1xSB FlorActiv per day.


Paul L
Veteran Member


Date Joined Dec 2005
Total Posts : 647
   Posted 4/21/2008 5:35 AM (GMT -6)   
It sounds as if it is starting to work for you. I sure hope so. Are others at your location on the same trial? How are they doing? There were 2 of us when I took the trial and it didn't help either one of us.
Paul
Diagnosed in 2000 at age 43 with UC extending half way across transverse colon.
Bad reaction to Asacol, Pentasa and Dipentum - can’t take any more 5ASAs.
Prednisone - worked well for 1 month, then side effects became unbearable.
6-MP - blood tests showed not metabolizing properly.
Corticosteroid enema, Flagyl, Ciprofloxin, VSL#3, Adacolumn Apheresis – no effect
Methotrexate with Remicade - 7 infusions with no improvement
Folic Acid and B12 injections.
Abatacept trial - no effect
 

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