Flagyl and risks?

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Veteran Member

Date Joined Apr 2006
Total Posts : 733
   Posted 5/1/2008 11:26 PM (GMT -6)   
Hi everybody.
I have been feeling lousy lately, nausea, D, bleeding, dizziness, etc.... I have refills on my Flagyl.  Flagyl usually helps me quite a bit when I have these kinds of problems.  So, my question is are there risks in taking Flagyl frequently?  I am not sure, but could it lead to nerve damage or other problems?  Thank you. 
Diagnosed with Left-sided UC in 1995 at age 15, Prednisone, Rowasa & Hydrocort. Enemas, Proctofoam, Sulfasalazine, Asacol, Probiotics, Fish Oil, Aloe Juice, Canasa, Enotcort, Colazol, Anamantle, Remicade, etc... had 1 inch deep rectal ulcer 2004, put on Remicade, August 2007:Increased Remicade dosage-700mg every 6 weeks,diagnosed w/ Psoriatic Arthritis & Fibromyalgia Current meds: Clorazepate, Lomotil,  Tylenol pm, Lyrica started 1/17/08,  Humira started 4/4/08

Regular Member

Date Joined Oct 2007
Total Posts : 320
   Posted 5/2/2008 12:11 AM (GMT -6)   
There is info on Adverse Effects and Interactions over at Wikipedia.

Seems pretty safe.
"We are dreamers, shapers, singers and makers..." - Elric, Technomage
  • 28yo male, Australia. Diagnosed at 16yo. Currently enjoying severe pan-colitis.
    - 2xColazide, twice a day; 25mg of 6-MP a day; 1xAllopurnol;
    - 1xteaspoon of Metamucil 3 times a day;
    - 1xBIOCeuticals UltraBiotic 45 per day + 1xSB FlorActiv per day.

Elite Member

Date Joined Feb 2004
Total Posts : 20577
   Posted 5/2/2008 12:21 AM (GMT -6)   
Well it's an antibiotic so it's gonna kill of good bacteria as well which in turn leaves your system vulnerable so be sure to take a good probiotic daily and indefinitely regardless of being on antiobiotics...and while on antis take the probiotics at least 2 hours after you're done taking your antis for the day.

My bum is broken....there's a big crack down the middle of it!  LOL  :)

New Member

Date Joined May 2008
Total Posts : 6
   Posted 5/2/2008 4:57 AM (GMT -6)   
Hi - I was on flagyl and it really messed me up. I don't know what it was with that medicine but about an hour after taking it I felt almost suicidal. I knew I just had to wait it out but I refuse to go back on that particular medicine because it was worse than the cure. Good luck

Veteran Member

Date Joined Dec 2007
Total Posts : 536
   Posted 5/2/2008 7:38 AM (GMT -6)   
I have been on flagyl several times over the years. The last time was last summer and it slayed me - numbness, depression, disturbed sleep, urinary backup, and now, 9 months later, I still have the diarrhea that the flagyl caused. Apparently some people react well to it, others are hit with harsh side effects. I say look into the falgyl effects and make an informed choice.
21 years of UC which started after quitting smoking. In and out of flares which are usually triggered by antibiotics.


  • 3 500mg Pentasa a day
  • Probiotic
  • Psyllium powder.

Veteran Member

Date Joined Feb 2006
Total Posts : 5698
   Posted 5/2/2008 7:57 AM (GMT -6)   
Flagyl isn't really recommended for treating UC. The antibiotic properties will slow down the diarrhea but it doesn't correct it unless the diarrhea is caused by a bacteria. Rather then continuing to treat yourself with Flagyl you should talk with your GI about your symptoms and see if there is an alternative.

dx proctitis in 1987
dx UC in 1991, was stable until 1998

1998 started prednisone, asacol, pentasa, nortriptylene, ativan, 6MP, rowasa enemas and suppositories, hydrocortisone enemas, tried the SCD diet, being a vegetarian, omega 3s, flax, pranic healing, yoga, acupuncture, probiotics

2000 lost all my B-12 stores and became anemic

2001 opted for j-pouch surgery- now living life med-free

Eva Lou
Veteran Member

Date Joined Sep 2006
Total Posts : 3442
   Posted 5/2/2008 8:29 AM (GMT -6)   
I agree with Sue- self-medicating with anti-biotics is not a good idea. The symptoms you describe- they sound like UC symptoms with the exception of the dizziness- it's most likely a reaction to the Humira, don't you think? I would call your GI asap. I personally HATE Flagyl- it's gotta be my least fave of all the anti-biotics.

diagnosed with UC '02
Asacol- 8 tabs/day
Remicade infusions
Imuran- 100mgs/day

Elite Member

Date Joined Feb 2004
Total Posts : 20577
   Posted 5/2/2008 1:11 PM (GMT -6)   
I've had GI's prescribe flagyl to me for my crohns but I never noted any improvements what so ever any time I've ever been on it.

My bum is broken....there's a big crack down the middle of it!  LOL  :)

Veteran Member

Date Joined Apr 2006
Total Posts : 3402
   Posted 5/2/2008 1:58 PM (GMT -6)   
Flagyl is icky! It made me feel very spacey and disconnected. Not to mention the smell when it left my body - or the taste.

Better to call your doc and discuss.
Pan-colitis and GERD diagnosed May 2003
Osteopenia diagnosed Feb 2006
Status:  Flaring :(
30mg pred, Asacol 12 per day,  Azathioprine 100mg, Aciphex, Forvia, and Pro-Bio
Co-Mod for the UC forum:  Keep HealingWell running smoothly:  www.healingwell.com/donate

Regular Member

Date Joined Apr 2008
Total Posts : 20
   Posted 5/3/2008 12:42 AM (GMT -6)   
Boy, I'm with a lot of these others who seriously hate Flagyl. I had to take it a couple times, but only for specific bacterial infections, never for UC. I do not like the side effects of it at all, made me jittery/jumpy and bad taste in my mouth. Both times I took it, I couldn't wait for the course to be over. I would definitely talk it over with your doctor. There are definitely also dangers with repeated use of antibiotics, like the development of drug-resistant bacteria strains.
M, 44, SF, CA
ulcerative proctitis diagnosed in 1989, active 3 years, but controlled with Sulfasalazine and cortisone enemas
15 year remission off all meds 1992-2007
ulcerative colitis returned May 2007, no remission since
concurrent infections at diagnosis: c-diff, cmv colitis, both treated and negative
meds: asacol, 4-3x/day
started remicade 4/22/08

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