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TraciZ
Regular Member


Date Joined Aug 2007
Total Posts : 255
   Posted 5/2/2008 6:15 PM (GMT -6)   
I'm just wondering if I switch my 5-ASA drug if I may have a better outcome? I'm on Lialda 2 pills twice/day and still flaring. (plus canasa and I just quit pred 20 mg.'s cold turkey- I know- not the smartest thing, but that's another post.) When 1st diagnosed, I went on colazal and got better, but then had really bad side effects (I lost control of my bowels). Does the brand name really make that much of a difference, even though they're all the same med mesalamine? I wonder if it's worth a shot to try asacol? I can't stand the prednisone!

Mrsarcasm
Regular Member


Date Joined Oct 2003
Total Posts : 80
   Posted 5/2/2008 7:38 PM (GMT -6)   
I was talking Asasol ( 6 pills daily) for 14 years adn Rowassa. Had a flare. My doc switched me to Lialda. While taking pred. I was not getting better. I suggested to my doc that he increase my dosage of Asacol rather than put me on 6mps since I am mild to moderate. Within 3 days I noticed a difference. Asacol is good as long as you are on the right dosage. Rowassa is also very important.
___________________________________________________
 
Asacol - 9 pills
Lialda - 4 pills daily
Rowassa Enema - 1 nightly
Flora-Q- 1 daily
Multi Vitiam - 1 daily
Vitiam C - 500mg daily
Prednisone - 30mg, 25mg, 20mg, 15mg


jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10407
   Posted 5/2/2008 9:52 PM (GMT -6)   
Asacol and Lialda are the same drug. Colazal is a different drug in the same family - much as ibuprofen and aspirin are in the same family. We may have good, bad or no reactions to Mesalamine (Asacol/Lialda) or to Colazal (Balsalazide.) Unfortunately, just to mess us up more, sometimes the "non-active" ingredients in tablets or capsules can also give us reactions. It couldn't hurt to try Asacol before going to stronger drugs, it just could work.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Avascular necrosis in both shoulders is my "forever" gift from steroid therapy.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.


quincy
Elite Member


Date Joined May 2003
Total Posts : 30408
   Posted 5/3/2008 12:20 PM (GMT -6)   
I wouldn't say that ibuprofen and aspirin are in the same family since ibuprofen isn't a salicylate...but are in the same classification or category of being NSAIDs and analgesics.

Traci....you should consider to increase the rectal meds from suppositories to retention enemas...increasing the 5ASA dosage from 100omg to 4000mg.

You will have some side effects from dropping the pred.....but hang tough to get the other meds working.

I would stay on the Lialda....you're already at the top dosage...maybe even too much?

What exactly are your symptoms?

quincy
*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


TraciZ
Regular Member


Date Joined Aug 2007
Total Posts : 255
   Posted 5/3/2008 1:43 PM (GMT -6)   
Hi. Thanks for your posts.

Symptoms= bleeding, cramps, diarrhea, gas

I just had my dose increased on 4/24 to 4 lialda/day. I wonder if it'll just take a while to kick in at this dose. I'd read in other posts that some 5ASA meds don't work for some of us. I was wondering if that was the case for me w/lialda.

I've always been hesitant to try the rowasa, because I'm embarrassed and not sure what to expect. Is the rowasa 4000 mgs? I'm starting to reconsider.

expecting226
Regular Member


Date Joined Jul 2007
Total Posts : 402
   Posted 5/3/2008 2:01 PM (GMT -6)   
Although Lialda and Asacol are the same medication (mesalamine), they work in different ways - i.e. deposit the medication in different parts of the bowel - and their doses last different amounts of time - i.e. why you have to take more Asacol vs. Lialda. It may be that mesalamine works for you but the method of deposit isn't right for your affected areas. I would try another mesalamine before ruling it out completely.

And, I agree with Quincy... go for Rowasa retention enemas. If they work for you, you will notice a difference very quickly.
Proud new mom of a beautiful baby boy!
Current Medications:
- Asacol (4 pills, 3x per day)
- Rowasa (1 enema daily, as needed)
- Folic Acid (1 mg, 1x per day)
- Calcium (600 mg, 2x per day)
- Prenatal Vitamin (1x per day)


quincy
Elite Member


Date Joined May 2003
Total Posts : 30408
   Posted 5/3/2008 3:10 PM (GMT -6)   
Lialda is 1200 mg....so, that means that 1 lialda = 3 asacol. That's it.

The method of deposit is retarded...meaning that it dispurses throughout the colon at different ph levels. If one's ph level isn't as per the coating requirements, it might get dissolved later or not at all.

Some 5ASAs depend on the bacterial level....so that's were the differences of some are.

There are different 5ASA meds....not all mesalamine/mesalazine.

START THE ROWASA....YES...I'M YELLING BUT IN A NICE WAY!!!
I must have no shame because I've used Salofalk enemas for over 19 years. My husband had to put the first one in...that's it.

quincy
*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10407
   Posted 5/3/2008 3:44 PM (GMT -6)   
Actually, the NSAIDS are generally spoken of as being a class or family of drugs. Salycylates are naturally occurring compounds which are found in many foods as well as aspirin, but not generally considered a family of drugs.

Ah well, po-tay-to, po-tah-to.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Avascular necrosis in both shoulders is my "forever" gift from steroid therapy.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.


munchkindd
Regular Member


Date Joined Oct 2007
Total Posts : 348
   Posted 5/3/2008 4:15 PM (GMT -6)   
Have you ever tried Azulfidine? If you are not allergic to sulfa, it may be a good choice. I know this was the drug that was commonly used quite a few years ago. I don't know why the Doc's just seem to write scrips for the much more powerful drugs without first trying this. It has definitely worked for me when Asacol didn't help at all. I know there are others on this forum who also have good luck with Azulfadine......Somebody on this forum gave me a link to a site that a GI swore by Azulfidine for UC. This particular GI really felt this was the best medicine for UC. (and I don't remember what the site was) I know that some people can't take it because of the sulfa. My newest GI didn't prescribe this to me because she said that since I was dx'd 27 years ago, they have come out with new and improved meds, and put me on Asacol. I was on that for 2 whole years with no change at all. Once I was back on the Azulfidine, I went into remission within 2 months. I don't think that is a coincidence. I'm not saying that this is the best medicine for everybody. We all know that what works for one, doesn't necessarily work for another. "New and improved" doesn't alway mean it's going to work better. I just wonder why this drug isn't tried alot more often, considering the side effects are so much more minimal than some of the other drugs. I would go into detail about the benefits of Docs writing scrips for higher priced drugs etc.........but it would fall under "conspiracy" which I believe is not allowed here. I wish you luck with whatever you choose to do. I only wish everyone who suffers from this dreadful disease could enjoy a very long remission.
*******Donna*******
 
diagnosed with uc 27 years ago.  Enojoyed 20 year remission with just minor blips here and there (approximately 16 of those years without any meds)
 
In a flare for 2 very long years which Asacol didn't help at all.  Finally in remission again since Jan 2008, can't believe it..............
 
currently on Sulfasalazine 2 tabs 3x day. Folic acid, mesalamine enema 2 x a week. Omega 3, Probiotics, multi vitamin, cacium supplement, Biotin....
 
I


AMK77
Veteran Member


Date Joined Mar 2008
Total Posts : 678
   Posted 5/3/2008 6:29 PM (GMT -6)   
I had terrible reactions to Lialda, Asacol and Colazal. I think I must be allergic to mesalamine. Would I be able to take Azulfidine - does it have mesalamine in it? My GI never mentioned that drug, he wanted to try steroids next and I really don't want to take those due to all the negative side effects.
Diagnosed 2/29/08 with Mild Universal UC
I've had UC since 2000 but was in remission for most of those 8 years med free
Lialda Colazal & Asacol made symptoms worse
Not taking any more meds for now. Trying a holistic approach.


munchkindd
Regular Member


Date Joined Oct 2007
Total Posts : 348
   Posted 5/3/2008 7:23 PM (GMT -6)   
Drug Therapies
Although medications cannot cure ulcerative colitis, they can reduce symptoms and help you control your condition. Sometimes, they can induce remission of the disease for a period of time. Medications commonly used to treat ulcerative colitis include:

AMK77....Sulfasalazine (Azulfidine) -- An older drug that reduces inflammation during acute flare-ups and is usually taken with folic acid. Side effects include abdominal discomfort, nausea, and lowered sperm count. Sulfasalazine can be effective, but newer drugs are available.

Mesalamine (Asacol, Rowasa) -- This drug reduces inflammation during acute flare-ups and helps prevent recurrences, and generally has fewer side effects than sulfasalazine.

Balsalazide disodium (Colazal) -- A different formulation of mesalamine that is designed to deliver the dose directly into the colon. It has fewer side effects.
*******Donna*******
 
diagnosed with uc 27 years ago.  Enojoyed 20 year remission with just minor blips here and there (approximately 16 of those years without any meds)
 
In a flare for 2 very long years which Asacol didn't help at all.  Finally in remission again since Jan 2008, can't believe it..............
 
currently on Sulfasalazine 2 tabs 3x day. Folic acid, mesalamine enema 2 x a week. Omega 3, Probiotics, multi vitamin, cacium supplement, Biotin....
 


dreamers
New Member


Date Joined May 2008
Total Posts : 11
   Posted 5/3/2008 9:57 PM (GMT -6)   
I read an article saying that if you have SEVERE UC that ASA could actually cause more flare ups. It made a lot of sense to me because that is the one medicine i have been on for years!!! I didnt have a flare up for two years then i started getting them again about 2 years ago and i get them all the time and recently have had a flare up since july. I am seeing a new dr so when i had another colonoscopy he explained that i had severe and he didnt want me taking the ASA. so for me it didnt do anything at all!!
**Stephanie**
 
23
Severe UC since 1999
 


quincy
Elite Member


Date Joined May 2003
Total Posts : 30408
   Posted 5/4/2008 12:03 AM (GMT -6)   
ASA (aspirin or acetylsalicylic acid) is NOT 5-ASA (5-aminosalicylic acid).... both are salicylates...both are antiinflammatories...different formulation...different reasons for use.

Some people cannot take any salicylate meds. Know what you're talking about and be clear about the formulations.

quincy
*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


dreamers
New Member


Date Joined May 2008
Total Posts : 11
   Posted 5/4/2008 6:12 AM (GMT -6)   
well i am sorry i did mean 5-asa.

**Stephanie**
 
23
Severe UC since 1999
 


Sherrine
Forum Moderator


Date Joined Apr 2005
Total Posts : 17685
   Posted 5/4/2008 9:57 AM (GMT -6)   

Years ago I was having the bleeding, gas, diarrhea, etc.  My doctor had me on Azulfadine and Librax and it really helped me a lot.  It's not the newer stuff but it would now be less costly since it's generic and, as I said, it worked for me.

 

Sherrine


Forum Moderator/ Fibromyalgia
***********************
Fibromyalgia, Crohn's Disease, Ostomy, Diabetes, Autoimmune Inner Ear Disease, Osteoporosis
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
God does not give us a spirit of fear, but of power and of love and of a sound mind.    2 Timothy 1:7


MMMNAVY
Veteran Member


Date Joined Jul 2006
Total Posts : 6927
   Posted 5/4/2008 10:02 AM (GMT -6)   
Whoa, slow down here... this is a forum for mutual support.

Dreamers, you have my apologies for other members snippyness.

Everyone makes mistakes, and not everyone is at the same place in life.

I think a simple explanation is that both painkillers mentioned above can make one's bleeding or pain worse.

Traci, I think it is safe to say you have some med options here.

Thank you for everyone's input.
Forum Co-moderator
We will find a way, or make one.-Hannibal (crossing the Alps in the 15th Century on war elephants)
Praise in public, chew in private.
Make sure your suffering has meaning....
All suggestions/options/opinions are caveated with please consult with your local health care provider...

Post Edited (MMMNAVY) : 5/4/2008 10:09:08 AM (GMT-6)


quincy
Elite Member


Date Joined May 2003
Total Posts : 30408
   Posted 5/4/2008 1:18 PM (GMT -6)   
MMMMNAV, slow yourself down and don't jump to conclusions.
Please don't assume anything I say is snippy and don't make any apologies for me.
I can be snippy and you'll know when I do.  I don't sugar coat with hearts and kisses and you darn well know I support members.

Ask me for clarification and allow me to speak for myself.


Respectfully,
quincy


*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

Post Edited (quincy) : 5/4/2008 1:24:25 PM (GMT-6)


quincy
Elite Member


Date Joined May 2003
Total Posts : 30408
   Posted 5/4/2008 1:21 PM (GMT -6)   
dreamers said...
well i am sorry i did mean 5-asa.


No need to apologise....I was just being straight forward and to the point.  That's a misunderstood trait of mine.

Clarity regarding meds....especially when they can be confused and misunderstood,  is important.

quincy


*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


TraciZ
Regular Member


Date Joined Aug 2007
Total Posts : 255
   Posted 5/4/2008 2:18 PM (GMT -6)   
Wow. This is a lot of info! I am certainly glad that there are a lot of choices. I've been flaring for the better part of the last 4 years. (I was misdiagnosed after my 1st colonoscopy, because I wasn't flaring at the time, and didn't get treatment for 2 years.) I'm gonna look into the Rowasa, Azulfadine and Librax. I also need to be careful, because I have a positive ppd and can't take certain classes of drugs. I feel better knowing that with the right medical care, I'll be able to find a coctail that works!

The funny thing is, after all this discussion, I think the 4 lialda/day is starting to kick in! (Cross your fingers.)

What I really like about this site is that you can get info from a lot of different sources and perspectives. My experience has always been that of info and support. I appreciate that and that's the reason I choose to continue on this site. I'm sure posts can be interpreted in different ways, but I have no doubt that people here have the best intentions for others.

MMMNAVY- I didn't know you read this forum, too. I appreciate your input on both.

jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10407
   Posted 5/4/2008 2:29 PM (GMT -6)   
Quincy, MMMNAVY is not alone in noticing your tone. This forum is for support and information. There is room for open discussion, but please remember to remain respectful and courteous. Things like "Know what you're talking about" do sound like you're being snippy to most people, even if you don't mean them that way. I'm asking that you stop now. Let the last word go, and let Traci get the information she came for.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Avascular necrosis in both shoulders is my "forever" gift from steroid therapy.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.


MMMNAVY
Veteran Member


Date Joined Jul 2006
Total Posts : 6927
   Posted 5/4/2008 2:37 PM (GMT -6)   
Traci,
I read several forums. I sure hope you have found some relief for your pain. Still concerned about that other issue, since you really did not get a really good answer. I am sorry the option I suggested did not work out.
There are plenty of options for you in regards to your IBD (since you are not really sure of your dx right now <or has that been confirmed since we last chatted?> I wonder about getting an EGD done?) and we always welcome more questions.
Most importantly I hope you have gotten the relief you need.
Navy
Forum Co-moderator
We will find a way, or make one.-Hannibal (crossing the Alps in the 15th Century on war elephants)
Praise in public, chew in private.
Make sure your suffering has meaning....
All suggestions/options/opinions are caveated with please consult with your local health care provider...


quincy
Elite Member


Date Joined May 2003
Total Posts : 30408
   Posted 5/4/2008 3:53 PM (GMT -6)   
J & M hmmm, well, remember it's also your perspective....one word doesn't need a whole post of bashing either. Moderating can request an expanation rather than negating.

Your tone is intended as well remember...don't make more out of it than necessary.

I'll tone it down to a point without changing my "personality". I'm still to the point....

respectfully,
quincy
*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


damo123
Veteran Member


Date Joined Jul 2007
Total Posts : 714
   Posted 5/4/2008 4:03 PM (GMT -6)   
Let's talk about numbers.

On average if a person has UC then the chance of a flare in a one year period is 0.5. This is a broad sweeping generilisation but lets work with it for the time being. On average if you take only a 5ASA over a one year period the chance of a flare reduces to 0.33. Thus a 5ASA drug offers you 0.1667 or 1 divided by 6 chance of extra protection per year on average.

Now 1/6 looks a pretty good gamble for someone with maybe mild symptoms but if someone suffers from UC pretty badly I cant see them take comfort from merely 16.67% extra protection.

Plus i'm sure this 1/6 is boosted up by the market surveys carried out by companies. It would be noble but highly unrealistic to think that the numbers quoted are as good as that. The actual extra protection offered by 5ASA could be nearer 10% per annum.

The source of my figures above come from literature produced by Asacol distributors.
 
D
 
PS: I think that some people above need to look at forum rule 3 including the moderators.
 
 


Asacol and Iron as Needed. <I've fallen back into unhealthy ways and really enjoying it, burb!>
 
"Whatever you do in life don't berate yourself too much nor contragulate yourself too much. Your choices are half chance. So are everybody elses'"
 
 
 
 
 
 
 

Post Edited (damo123) : 5/4/2008 4:12:48 PM (GMT-6)


quincy
Elite Member


Date Joined May 2003
Total Posts : 30408
   Posted 5/4/2008 4:18 PM (GMT -6)   
damo...would that be both rectal and oral 5ASA or just oral?

Interesting...your the one to ask for the ###, however. But do you know how many docs don't use 5ASA initially? Would that have something to do with the stats?

q
*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


damo123
Veteran Member


Date Joined Jul 2007
Total Posts : 714
   Posted 5/4/2008 4:22 PM (GMT -6)   
That refers to oral 5ASA.

It doesnt matter how many docs use 5ASA once there is a signifcant number then the mean of both the subgroup who use them will equal the mean of the actual population who use them. So given a large enough sample size then the statistic holds. And we most certianly have a large enough sample size in this case.

D
Asacol and Iron as Needed. <I've fallen back into unhealthy ways and really enjoying it, burb!>
 
"Whatever you do in life don't berate yourself too much nor contragulate yourself too much. Your choices are half chance. So are everybody elses'"
 
 
 
 
 
 
 

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