Ped. GI changing meds

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Regular Member

Date Joined Nov 2006
Total Posts : 289
   Posted 5/7/2008 9:48 PM (GMT -6)   
My daughter's GI is changing her meds from Pentasa to Asocol (sp?), should I be worried about anything?  The reason for the change is she is now big enought to take pills.  I was told the Asocol doesn't breakdown until it hits the colon and thats better for her.
Looking for thoughts.
Daughter 5, UC
Pentasa 2X2 daily
Omega 3
Folic Acid 1000mcg.

Elite Member

Date Joined Mar 2003
Total Posts : 10407
   Posted 5/7/2008 10:30 PM (GMT -6)   
I only know my GI doesn't use Pentasa for UC. He says it tends to deliver the drug at the end on the small intestine or just at the beginning of the colon, so it isn't as effective. I was unable to tolerate Asacol, but since your daughter was on Pentasa she'll probably do fine.
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Avascular necrosis in both shoulders is my "forever" gift from steroid therapy.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.

Veteran Member

Date Joined Mar 2008
Total Posts : 1766
   Posted 5/7/2008 11:13 PM (GMT -6)   
I still go to a Ped GI (I know, I need to switch to an adult one), but I started off with and am still taking Asacol. Asacol worked really well for me for the first 6 months that I took it--my first flare was gone in less than a month. I'm still taking Asacol and just adding Proctofoam to tame a flare. I haven't had any side effects with Asacol.

Female, Age 19, Dx w/ UC August 2007
Seasonal allergies
9 Asacol/day, 1000 mg Canasa (caused side effects)
Digestive Advantage (Crohn's & Colitis), 2 pills/day
Calcium chews

Regular Member

Date Joined Nov 2006
Total Posts : 289
   Posted 5/8/2008 3:39 PM (GMT -6)   
Thank you. The reason she was on Pentasa is because it is the only med you can open and pour into applesauce. She was to small to take pills when she was diagnosed. Now that she can, it's on to Asacol.
Daughter 5, UC
Pentasa 2X2 daily
Omega 3
Folic Acid 1000mcg.

Veteran Member

Date Joined Apr 2007
Total Posts : 1366
   Posted 5/8/2008 4:28 PM (GMT -6)   
Poor girl. I can't imagine having to take these pills at age 5. I can barely take them now! I would definitely not recommend Colazal because those always got stuck in my throat and then dissolved, causing burping, burning, nausea, TERRIBLE taste in my mouth, and I'm pretty sure it lead to the ulcerations in my esophagus. Asacol is definitely easier to swallow, though for me the pills never actually break down. The doctors always told me the medicine is in the coating but I don't know.
What about Lialda? I don't have any experience with it yet and it just got approved for colitis but it's basically the same thing as Asacol and you only have to take one pill a day. I wonder if that would be an option for her?
Female, 22, Ulcerative colitis (pancolitis) since 1999; GERD; gastritis; osteopenia in hip & lumbar region of spine from long term prednisone use

Current Meds:
10mg Lexapro (for depression/social anxiety)
125mg Azathioprine
4800mg Asacol (Four 400mg tablets, three times a day)
10meq Potassium

Regular Member

Date Joined Jul 2007
Total Posts : 402
   Posted 5/12/2008 1:33 PM (GMT -6)   
Pentasa and Asacol are both the same medication - mesalamine. They are just packaged differently. So, I would guess that your daughter should be fine on the Asacol if she was fine on the Pentasa. The active ingredients are the same.

I have never experienced any side effects from Asacol. My GI has always told me that it is, generally, one of the best tolerated meds for UC. Your Dr. is right. It is not systemic. It opens in the large colon and deposits the medication accordingly.
Proud new mom of a beautiful baby boy!
Current Medications:
- Asacol (4 pills, 3x per day)
- Rowasa (1 enema daily, as needed)
- Folic Acid (1 mg, 1x per day)
- Calcium (600 mg, 2x per day)
- Prenatal Vitamin (1x per day)

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