How long for Imuran to work?

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New Member

Date Joined May 2008
Total Posts : 12
   Posted 5/11/2008 8:32 PM (GMT -6)   
I have had IBS for 45 years and was diagnosed with left side ulcerative colitis in Dec. 07.  Early treatment with Rowasa, Pentasa, Entocort, Colozal and antibiotics did not bring remission.  Prednisone with Colozal did cause a reduction in frequency of bowel movements and other symptoms.  Once tapered off of Prednisone symptoms returned.  Have been on low dose of Prednisone since Feb.  Began Imuran on Feb 21, once determined I was steroid dependent.  I currently take 100 mg of Imuran, 9 Colozal and 10 mg of Prednisone daily and have 7 to 12 bowel movements daily with occasional accidents.  Should this combination of treatments have caused remission in these two months or am I impatient?

Regular Member

Date Joined Dec 2007
Total Posts : 354
   Posted 5/11/2008 8:58 PM (GMT -6)   
Do you think you have IBS as well as UC? My understanding it that it is common to have both. If so how have you treated the IBS in the past? You might find success in treating both. That is what I am currently trying. It is difficult to tell the difference in symptoms as they are the same except for blood in the stool.

I am sorry you are having so much trouble. I think Imuran can take several months to kick in but I personally haven't tried it yet. Someone else who has will chime in soon.
Jessica 26/F On Entorcout again...
dicyclomine 10Mg before meals/bed
Citalopram 10 MG
Asacol 4pills /three times a day(from 2 pills/ three times a day)
Culturelle once daily
Tried (Entorcort EC 9ml/day and Prednisone)

Elite Member

Date Joined Mar 2003
Total Posts : 10407
   Posted 5/11/2008 9:56 PM (GMT -6)   
Welcome to HealingWell, bowelsafire. I feel your pain, believe me.

The average on Imuran, they say, is three months, but it can take as long as six. You should be having frequent blood counts as liver function testing, and periodic blood tests being sent to check on your Imuran level. People metabolize the drug differently, so dosage is based on blood levels rather than body weight as in many medications.

I'm sorry you've joined the group of UC sufferers, but glad you found us here at HealingWell. This is a great place to learn from others' experience and get support.
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Avascular necrosis in both shoulders is my "forever" gift from steroid therapy.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.

Regular Member

Date Joined Oct 2007
Total Posts : 320
   Posted 5/12/2008 2:43 AM (GMT -6)   
Took 6 months for me...
"We are dreamers, shapers, singers and makers..." - Elric, Technomage
  • 28yo male. Brisbane, Australia. Diagnosed at 16yo. Currently enjoying severe pan-colitis.
    - Participating in the Golimumab trial as of 1st May, 2008;
    - 2x Colazide, twice a day; 25mg of 6-MP a day; 1xAllopurnol;
    - 1x teaspoon of Metamucil 3 times a day;
    - 1x BIOCeuticals UltraBiotic 45 + 1x SB FlorActiv twice a day.

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 5/12/2008 6:06 AM (GMT -6)   
Hi and welcome to Healingwell :) Yes, you are a bit impatient but who can't be with this disease eh? We all want to feel better like right now! I does take a while for it to work and if by 6 months you have absolutely no improvement whatsoever, you need to discuss your options with your GI.
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Allergies-Singulair
~Secondary Reynauds Syndrome-'04-Norvasc~Spinal Stenosis~Sacroiliitis-epidural injections
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Veteran Member

Date Joined Dec 2005
Total Posts : 3238
   Posted 5/12/2008 7:40 AM (GMT -6)   
Welcome! Took almost 6 months for Imuran to kick in for me. Hang in there!!!!
Tabitha (Tab)

100mg Azathioprine, 2 Fibercon, Colazal-9 a day, Acidopholis Pearls, Nexium
Co-Moderator UC Forum

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