t-bet protein causes colitis in 100% of mice...

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ediekristen
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Date Joined Apr 2007
Total Posts : 1366
   Posted 5/15/2008 3:17 PM (GMT -6)   

I stumbled upon this article and found it interesting, but I'm wondering why I've never heard anything about it before? It sounded pretty significant.. I don't know. I just thought I would share!

Deficiency Of Immune System 'Peacekeeper' Pinpointed In Mice As Cause Of Ulcerative Colitis

http://www.sciencedaily.com­/releases/2007/10/071004121042.htm

--The researchers have linked ulcerative colitis in mice to a deficiency of a molecular "peacekeeper" in the immune system, allowing harmful bacteria in the large intestine to breach the bowel's protective lining and trigger damaging inflammation.

"We have identified a new molecular player, T-bet, and when it's missing, there is spontaneous onset of the disease in the mice," said Glimcher. "The importance of this study is that we now have a novel model for ulcerative colitis: The disease appears in 100 percent of the animals and looks just like the human disease."

Post Edited (ediekristen) : 5/15/2008 3:31:37 PM (GMT-6)


ediekristen
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Date Joined Apr 2007
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   Posted 5/15/2008 3:36 PM (GMT -6)   
I know drugs like Remicade and Humira are anti-TNFalpha drugs, so it seems they could be the most beneficial... I wonder if there is a test out there to see if you are T-bet deficient or if you have excessive amounts of TNF to decide if it would be the best treatment?

The fact that it was transmitted between mice via skin to skin contact was a bit concerning... I just always worry about this. I mean, they tell us it is NOT "contagious" or transmittable in anyway, but realistically, they don't even know what causes it so how could they know for sure? Maybe you just have to come in contact with the right (or in their case, wrong) person who is predisposed to cause it to develop?
Female, 22, Ulcerative colitis (pancolitis) since 1999; GERD; gastritis; osteopenia in hip & lumbar region of the spine from long term prednisone use.

Current Meds:
10mg Lexapro (for depression/social anxiety)
Digestive Advantage: Crohn's and Colitis formula (2 pills per day, started 5/14/08)
125mg Azathioprine
4800mg Asacol (Four 400mg tablets, three times a day)
 
 
 


Pooie1981
Regular Member


Date Joined Mar 2008
Total Posts : 274
   Posted 5/15/2008 4:11 PM (GMT -6)   
A-M-A-Z-I-N-G

Thank you for posting.
Jenn 26/female
Ulcerative Colitis Diagnosed May 2004
Sulfasalazine 500MG 4 times per day
Daily Vitamin for Women and Folic Acid


ediekristen
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Date Joined Apr 2007
Total Posts : 1366
   Posted 5/15/2008 4:16 PM (GMT -6)   
No problem :) I was surprised I hadn't seen it here before and couldn't find it when searching. It seems like very promising research because if this caused colitis in every mouse, and they were actually able to cure it, then that could mean further advances in helping us (or maybe someday even finding a cure).. I hope.

I feel so selfish for wanting to have children sometimes because they say your child may be 5x more likely to develop IBD if one parent has it, and I would hate to pass this terrible thing on to them, but I keep telling myself "Even if they don't find a cure in time for me, hopefully they will at least have one for my children"
Female, 22, Ulcerative colitis (pancolitis) since 1999; GERD; gastritis; osteopenia in hip & lumbar region of the spine from long term prednisone use.

Current Meds:
10mg Lexapro (for depression/social anxiety)
Digestive Advantage: Crohn's and Colitis formula (2 pills per day, started 5/14/08)
125mg Azathioprine
4800mg Asacol (Four 400mg tablets, three times a day)
 
 
 


tjf
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Date Joined Dec 2005
Total Posts : 3238
   Posted 5/15/2008 4:21 PM (GMT -6)   
In the future, if available, please post links of the reseach instead of cutting and pasting. It is actually a forum rule. Thanks:)
Tabitha (Tab)

100mg Azathioprine, 2 Fibercon, Colazal-9 a day, Acidopholis Pearls, Nexium

http://www.healingwell.com/donate
Co-Moderator UC Forum


ediekristen
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Date Joined Apr 2007
Total Posts : 1366
   Posted 5/15/2008 4:25 PM (GMT -6)   
I have the link at the bottom as well, I didn't realize I should post that instead of the article though. Sorry about that!
Female, 22, Ulcerative colitis (pancolitis) since 1999; GERD; gastritis; osteopenia in hip & lumbar region of the spine from long term prednisone use.

Current Meds:
10mg Lexapro (for depression/social anxiety)
Digestive Advantage: Crohn's and Colitis formula (2 pills per day, started 5/14/08)
125mg Azathioprine
4800mg Asacol (Four 400mg tablets, three times a day)
 
 
 


tjf
Veteran Member


Date Joined Dec 2005
Total Posts : 3238
   Posted 5/15/2008 4:47 PM (GMT -6)   
No problem!!!!
Tabitha (Tab)

100mg Azathioprine, 2 Fibercon, Colazal-9 a day, Acidopholis Pearls, Nexium

http://www.healingwell.com/donate
Co-Moderator UC Forum


Pooie1981
Regular Member


Date Joined Mar 2008
Total Posts : 274
   Posted 5/15/2008 5:13 PM (GMT -6)   
Personally, I still fully plan on having children. AS you said... they might have a cure for them. the disease is controllable, to some extent. I could understand if it was a terminal illness but not something like UC. You shouldn't think like that. ;o)
Jenn 26/female
Ulcerative Colitis Diagnosed May 2004
Sulfasalazine 500MG 4 times per day
Daily Vitamin for Women and Folic Acid


quincy
Elite Member


Date Joined May 2003
Total Posts : 30687
   Posted 5/16/2008 3:46 AM (GMT -6)   
Remember that some UC-linked diseases...such as PSC...can be fatal. So, UC isn't as benign as one can make of it.

As well....most of us have other autoimmune disease/disorders...

Make your decision to have children wisely.

NO ONE wants UC.....and I'd much prefer to not have ANY of the "traits" I've inherited.....

quincy
*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


princesscolon
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Date Joined Apr 2006
Total Posts : 733
   Posted 5/16/2008 5:43 AM (GMT -6)   
I found the article amazing, I wish I had my GI's email address so I could send the link to him. I am confused about a few things after reading the article. It sounds as though Remicade/Humira should work for most patients, but they don't always. Also, how in the world did those baby mice get the disease? I would think if it was "contagious," then a lot more people would have UC. And, why did the babies get it, what about the mates and other adult mice?? Developing immune systems?? Maybe it is only transmitted to baby animals? Someone on the forum has a cat with colitis... I am so glad to hear of this research, it is fascinating. Poor mice having bloody D and all the other things we go through. I hope that if there is reincarnation I don't come back as a lab rat!
Diagnosed with Left-sided UC in 1995 at age 15, Prednisone, Rowasa & Hydrocort. Enemas, Proctofoam, Sulfasalazine, Asacol, Probiotics, Fish Oil, Aloe Juice, Canasa, Enotcort, Colazol, Anamantle, Remicade, etc... had 1 inch deep rectal ulcer 2004, put on Remicade, August 2007:Increased Remicade dosage-700mg every 6 weeks,diagnosed w/ Psoriatic Arthritis & Fibromyalgia Current meds: Clorazepate, Lomotil,  Tylenol pm, Lyrica started 1/17/08,  Humira started 4/4/08


Old Mike
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Date Joined Jan 2007
Total Posts : 3870
   Posted 5/16/2008 8:47 AM (GMT -6)   
The links to the journal papers were posted on here at least 6 months ago,things get buried.
The docs tell you it is not transmitted but this and some other data indicate that it might be.
Old Mike

Sara14
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Date Joined Mar 2007
Total Posts : 4386
   Posted 5/16/2008 11:36 AM (GMT -6)   
One of the previous discussions on this topic: http://www.healingwell.com/community/default.aspx?f=38&m=932261
24 years old
Diagnosed with UC March 2007; yet to go into complete remission
Asacol 4 tablets 3x/day
Rowasa (generic) - nightly; Canasa (1,000 mg) in the morning
Nature's Way Primadophilus Reuteri 2/day; Chewable multivitamin; Metamucil; Viactiv


ucenigma
New Member


Date Joined May 2008
Total Posts : 13
   Posted 5/22/2008 11:05 PM (GMT -6)   
After 10 years of "studying" UC, I am neutral on "new" findings.....One thing about UC "cures" is that you have to ask, "What came first, the chicken or the egg?" Inflamation can be caused by many things, which is why Remicade works for some and doesn't work for others...same for Ascal, Meslamine, etc.

Just today, my dad gave me an article about a protien called "JAM-A" which researchers have found that in it's absence, cells of the stomach aren't as "tight" as they should be, so that little bad guys (ie, bacteria) can get in the gut and party hearty! Who knows? Another road to a cure.

Keep up the info. I would love to see some definite progress in one direction or another.
JD
Diagnosed with UC in 1997
Presently on Pred. and no options to do anything else....."in bed with Pred.." LOL!
 


expecting226
Regular Member


Date Joined Jul 2007
Total Posts : 402
   Posted 5/26/2008 6:54 AM (GMT -6)   
Regarding the choice to have children...  In general, there is a 2-5% chance of passing IBD onto one of your children.  The actual percentage varies based upon your specific genetic make-up.
 
Before we tried to conceive, we met with a genetic counselor at the Cleveland Clinic (my Clinic GI referred us there).  She was great.  After much genetic testing, she gave us our risk percentage.  It was lower than the average due to our genetic panels.  So, we moved forward.  
 
Of course, she didn't give us a guarantee... but no one ever does when it comes to children. 
Proud new mom of a beautiful baby boy!
Current Medications:
- Asacol (4 pills, 3x per day)
- Rowasa (1 enema daily, as needed)
- Folic Acid (1 mg, 1x per day)
- Calcium (600 mg, 2x per day)
- Prenatal Vitamin (1x per day)


mbx5
Regular Member


Date Joined Sep 2007
Total Posts : 365
   Posted 5/26/2008 12:55 PM (GMT -6)   

I started reading a little about T-bet and how Prolactin levels can effect it.  I found this although it is hard for me to understand:

 

http://www.nature.com/icb/journal/vaop/ncurrent/abs/icb200829a.html

 

I had a tumor on my pituitary gland and my prolactin levels were in the high 300's for a long time (possibly before I got my UC).  It may be possible that the tumor had something to do with it?
Normal prolactin levels for a male are in the 15 range.  300 is more than lactating mothers. 

I think that they are really on to something with the T-bet cells regardless.  I am very excited about this information.


33 yr old male. UC for 14 years. 5mg pred (tapering off), 12 pills Asacol per day, Dicyclomine (for cramps), 0.5 - 1mg Atavan per day (anxiety), Fish oil pills, Culturelle probiotics. Recent Endonasal brain surgery to remove non-cancerous hormone producing tumor on pituitary gland (And I am still more afraid of my UC!!)


bbc
Veteran Member


Date Joined Mar 2008
Total Posts : 1580
   Posted 5/26/2008 2:51 PM (GMT -6)   
If the inflammation was caused mainly by bad bacteria I'd imagine the most effective treatment would be to kill the bad bacteria and/or promote good bacteria which is what many of us take probiotics to increase the good, but unfortunately they have only limited effect.

To my understanding in IBD, the brian incorrectly tells the immune system to attack our healthy colons hence the inflammation and classification as an autoimmune disease.

Once science finds the exact protiens etc or lack thereof, we can get a truly effective treatment for the cause vs just trying to treat the symptoms. Once the eaxct link is found expect treatment to arrive between 3-10 years thereafter and IMHO it can't come quick enough.
 
Thanks for the links :-)

Post Edited (bbc) : 5/26/2008 2:09:14 PM (GMT-6)

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