Huimira Update

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Regular Member

Date Joined Apr 2008
Total Posts : 62
   Posted 5/19/2008 9:13 PM (GMT -6)   
Had my final "loading" dose last Wednesday. Typical 2 day great reaction-no blood or mucous but still 10 bms. My predisone was decreased to 30mg from 40mg.

Unfortunately, I have had the most persistent D since my flare began last Thanksgiving. Yesterday, I think I went 40+ times. Also, the stool is a different color (lighter brown ) and much more "pungent".

I am starting to wonder whether the Humira will work. How much longer do you think it takes to conclude that the Humira will work?

I am mentally preparing for the prospect of surgery. I have to do something to be able to live my life again.
54 yo male
First flare at age 49

Regular Member

Date Joined Oct 2007
Total Posts : 320
   Posted 5/19/2008 9:45 PM (GMT -6)   
While you are tapering the Prednisone, I wouldn't expect the Humira to do much of anything other then "absorb the blow". In my case with other similar drugs, I had to wait until I had tapered off of prednisone completely before I really started to see any improvement.

Have you been tested recently for c.diff? And have you told your GI about the change in stool colour and smell?
"We are dreamers, shapers, singers and makers..." - Elric, Technomage
  • 28yo male. Brisbane, Australia. Diagnosed at 16yo. Currently enjoying severe pan-colitis.
    - Participating in the Golimumab trial as of 1st May, 2008;
    - 2x Colazide, twice a day; 25mg of 6-MP a day; 1xAllopurnol;
    - 1x teaspoon of Metamucil 3 times a day;
    - 1x BIOCeuticals UltraBiotic 45 + 1x SB FlorActiv twice a day.

UC spouse
Regular Member

Date Joined Feb 2008
Total Posts : 70
   Posted 5/19/2008 11:45 PM (GMT -6)   
My husband is on Humira. Only after three months did we see any improvements. Like you, he experienced those 2-day great reaction. Good luck!
Husband diagnosed with pancolitis in May 2007 at the age of 31

Predisone 40 mg for two months-every time weaned off, symptoms came back, Mesalamine(substitute for Rowesa)enema for 21 days-didn't see results in 14 days so stopped taking it, symptoms seemed to get slightly worse.
Xifaxan-on and off
Current meds. : Humira, Colazal 12/day, Probiotic-Align, Fish Oil
Has never gone into remission

Regular Member

Date Joined Apr 2008
Total Posts : 163
   Posted 5/20/2008 9:21 AM (GMT -6)   
It took one month after the loading dose for me to notice any changes, but then there was rapid improvement -- no pain, formed stools, less frequency and urgency. Hang in there!
Dx Mild Proctitis 7/06 at age 33, Dx Severe Pan Colitis 5/07, Dx Crohn's Colitis 10/07
Failed Asacol, Lialda, 6-MP, Canasa, Rowasa, Entocort, and Remicade
On Humira since 1/08 with promising results, but can't get below 5mg Prednisone
Take Tylenol #3 as needed when not in close proximity to a bathroom.
Currently on 40mg Prednisone again since mid-March flare, ack
4/9/08 Humira dose increased to 40mg/week, Start slow Pred taper

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