on colazal, can't seem to get bleeding and mucous to stop..any suggestions?

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New Member

Date Joined Oct 2005
Total Posts : 2
   Posted 5/20/2008 4:01 PM (GMT -6)   
Hello all! This is my first post but I have been checking out the threads for awhile. It is extremely helpful and comforting to "listen" to others who know what I am going thru. Right now I am on Colazal. Was taking 3 pills 3x a day then Dr. upped me to 5 in the AM and 4 in the PM to help avoid forgetting the middle dose. Symptoms didn't seem to change or seemed to be worse some days. Saw on here that others were having side effects from higher doses. So I dropped back to 3 pills 3x a day. Things were better. Still didn't seem to control the bleeding and mucous. (If I could just get that to stop I would be fine!!!) Now I have dropped back to 2 pills 3x a day (Dr does not know this yet). This seems to be doing okay but have only been taking this dosage for about 4 days. Overall, every time I think I am improving I find myself running to the bathroom to avoid an accident. I was on the higher dosage for about a month. If that was making my symptoms worse I figure it will take a little time for my colon to repair itself at the lower dosage. any thoughts/input is appreciated. Thanks!

Veteran Member

Date Joined Apr 2007
Total Posts : 1366
   Posted 5/20/2008 4:49 PM (GMT -6)   
I would say if it's been over a month and your symptoms haven't improved, maybe it's time to ask your doctor about taking a different medication altogether. I didn't have luck with Colazal, or Asacol; Pentasa helped for a bit and then stopped. Sometimes one of them will work for you but not the others. I would think if the higher doses didn't help, the lower ones might not either.

Has your doctor had you take prednisone yet? As much as everyone hates it, sometimes it's the only option to get the flare under control so that the maintanence meds can work.
Female, 22, Ulcerative colitis (pancolitis) since 1999; GERD; gastritis; osteopenia in hip & lumbar region of the spine from long term prednisone use.

Current Meds:
10mg Lexapro (for depression/social anxiety)
Digestive Advantage: Crohn's and Colitis formula (2 pills per day, started 5/14/08)
125mg Azathioprine
4800mg Asacol (Four 400mg tablets, three times a day)

Regular Member

Date Joined Oct 2007
Total Posts : 348
   Posted 5/20/2008 5:23 PM (GMT -6)   
Are you taking any rectal meds? If not, it might be time. They can really help alot.
diagnosed with uc 27 years ago.  Enojoyed 20 year remission with just minor blips here and there (approximately 16 of those years without any meds)
In a flare for 2 very long years which Asacol didn't help at all.  Finally in remission again since Jan 2008, can't believe it..............
currently on Sulfasalazine 2 tabs 3x day. Folic acid, mesalamine enema 2 x a week. Omega 3, Probiotics, multi vitamin, cacium supplement, Biotin....

Elite Member

Date Joined May 2003
Total Posts : 31006
   Posted 5/20/2008 11:53 PM (GMT -6)   
Hi..welcome to the forum!

Is your UC limited or throughout?

There seems to be a fine line between too much and not enough 5ASA meds...some do cause more diarrhea/loose stool than others.

You really should also be on rectal meds to start....

In response to the suggestion of prednisone....you DO NOT have to take it. Especially if the doctor hasn't taken you to the 5ASA limit, both oral and rectal...then to the topical steroids such as Entocort and steroid enemas.
All that should be exhausted before ever considering systemic steroids such as prednisone.

When were you diagnosed? What were your initial symptoms and how much have you improved since taking the Colazal?
5ASA meds should really be given on an increase as needed rather than too much which can actually confuse symptoms.  It's a med that if one can use it....can be used for a very long time.  The goal really is to use the lowest dosage possible for the longest period of time....I'm pretty biased, however...it's been my only med for over 19 years.

Were you diagnosed from a colonoscopy or a sigmoidoscopy?


*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

Veteran Member

Date Joined Mar 2008
Total Posts : 1580
   Posted 5/21/2008 12:31 AM (GMT -6)   

Regular Member

Date Joined Aug 2007
Total Posts : 255
   Posted 5/21/2008 8:57 AM (GMT -6)   
First of all, welcome to the forum!
From what I understand, the bleeding is the last to go.

I'm currently having similar symptoms- blood and mucus. The rest of my symptoms have pretty much resolved. Also, like you, I'm taking Colazal 3X3. I had (without my GI's knowledge) reduced it to 2X3 for about 4-5 days, but then my symptoms got worse and I upped the dosage again.

I don't know what to suggest about the blood and mucus, because in 3 years, I haven't figured that out. But, I definately agree with the other posts: rectal meds definately help. In the past, Canasa has helped (a little) for me. Now, I'm trying hydrocortisone suppositories. Took the 1st one last night and it seems to be better this am.

Anyway, I just learned last night (in this forum there's a post called "steroid enemas") about steroid enemas, proctofoam, cortifoam, and "pb4" suggested bee propolis helps stop bleeding.

Good luck!
Tressa 34 (F)
Not sure of my dx- currently UC, but with skip lesions. Bloodwork is inconclusive for UC & Crohn's. Colonoscopy shows ulceration in terminal ileum and descending colon
Colazal 3X3/day
Lialda upped to 4/day,
Colazal 3X3/day
Phosphatidylcholine 4 (420 mg capsules) once/day

Veteran Member

Date Joined Aug 2007
Total Posts : 2204
   Posted 5/21/2008 9:07 AM (GMT -6)   
The book Listen to Your Gut by Jini Patel Thompson offers dietary recommendations to stop bleeding. L-glutamine, Mucosaheal and George's Roadrunner Aloe Vera also help heal the gut and stop bleeding.
Diagnosed with ulcerative colitis spring 1999.
Maintenance dose sulfasalazine.
Probiotics, l-glutamine and fish oil caps. George's aloe vera juice. Oregano oil antibiotic, antiviral, antifungal.

New Member

Date Joined Oct 2005
Total Posts : 2
   Posted 5/23/2008 7:15 AM (GMT -6)   
Thanks all! Very helpful. I am actually seeig improvement on colazal taken at 2 pills 3x a day. By improvement I mean less to no blood. Still have some mucous but think that is lessening as well. I will continue to self regulate meds. Sure my doc won't like that.
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