Hi, Just recently my 16 year old daughter was diagnosed with severe uc per colonostomy. She had severe symptoms for 8 or 9 months. No insurance, but finally took her out of town. We got a good Gi specialist. He started her on Remicade immediately, but didn't work very well, stopped the bleeding pretty much, but did nothing for the dd or the stomach pain. I really enjoy reading this forum, some great advice, and so many different cases. Kind of blows my mind, but very helpful and informative for me. We started methotrexate shots at home on the 23. 2nd shot her numbers were up this past Tuesday for inflamation. This is very scary for me so can't even imagine how she feels. Basically, just wanted to say that since we was diagnosed I have read this forum almost everyday. It is great. Has anyone else tried methotrexate, and if so has it work.