5-ASAs and 6-MPs

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New Member

Date Joined May 2008
Total Posts : 1
   Posted 5/29/2008 11:16 PM (GMT -6)   
Hi Everyone - I'm new to UC. Diagnosed in earlier this year after a colonoscopy. So far, I've used/tried: Mesalamine enema, Colozal (simply did not work), Lialda (caused blood in stool) and Sulfasalzine (allergic). Now I'm taking Pentasa. I've also been on Predisone for about 5 weeks now. I continue to have pain in my colon as well as lots of spasms across my chest area. My doctor says that if the Predisone doesn't start working soon, he wants to switch me to 6-MP. This scares me. I also have hypothyroidism (another auto-immune disease) - I'm not sure if that is relevant or not, but I thought I'd mention it.

I'm wondering if anyone out there has been through the 5-ASAs and is now using 6-MP - if so, how is it working out for you? Thanks!

Regular Member

Date Joined Oct 2007
Total Posts : 320
   Posted 5/30/2008 12:45 AM (GMT -6)   
Been on 5-ASA's. They didn't do much for me. Only one that kind of helped was Colazide (Colazal in the US).

I have been on 6-MP for the past 1.5 years. It also hasn't helped much, but I also have a dose of rather stubborn severe pancolitis.

6-MP isn't pleasant, but it sure beats going to the toilet a million times a day and its less bad then prednisone.

Hope you get some success soon!
"We are dreamers, shapers, singers and makers..." - Elric, Technomage
  • 28yo male. Brisbane, Australia. Diagnosed at 16yo. Currently enjoying severe pan-colitis.
    - Participating in the Golimumab trial as of 1st May, 2008;
    - 2x Colazide, twice a day; 25mg of 6-MP a day; 1xAllopurnol;
    - 1x teaspoon of Metamucil 3 times a day;
    - 1x BIOCeuticals UltraBiotic 45 + 1x SB FlorActiv twice a day.

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 5/30/2008 5:59 AM (GMT -6)   
I can not tolerate the other 5-ASA's but I can Colazal - though at times I think that it sometimes makes me worse and other times better. So the jury is still out on that one for me. I've been on 6mp for 1 1/2 years and I was highly hesitant about starting it. I was scared of messing with such a scary drug but after running to the bathroom 5-10xs a day, pooping razor blades and having a lot of bleeding for over 1 year just got to be too much. It was that or demand they rip that puppy out. So I opted for the less invasive method. I still flare while on 6mp but just not as severe and it is a lot easier to get under control now. Ultimately the decision is up to you if you want to start it or not.

Btw, welcome to Healingwell. I'm glad you found us but I'm sorry for the circumstance.
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc-'92-Colazal(9 daily),6mp(50-100mgs),Prilosec,Biotin,Forvia,Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa**~Allergies-Singulair
~Secondary Reynauds Syndrome-'04-Norvasc~Spinal Stenosis~Sacroiliitis-epidural injections
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Regular Member

Date Joined Dec 2007
Total Posts : 137
   Posted 5/30/2008 10:04 AM (GMT -6)   
Well I for one am in a similar boat LivingWithUC. 5ASAs don't do squat for me. The only thing for the past few months that has kept me from going to the bathroom 12 times a day is the prednisone. Even now its still 3 times a day, sometimes bloody sometimes not. I have another colonoscopy on Monday and a follow up on the 10th. I will probably get put on 6mps because 5ASAs cause more harm than good, or at least the ones that the VA has put me on. I've never even been offerd Colazal. So I dunno what to say. I don't want to be on 6mps (just the side effects scare me a bit), surgery I wont even entertain the thought of, and 5ASAs make me worse, but I'll take the lesser of the evils in attempt to feel better and if that is the 6mps, so be it.
Diagnosed UC 12/2007
Prednisone 15mg x 1/day ~ On going recent change 4/3/2008

Veteran Member

Date Joined Apr 2006
Total Posts : 3402
   Posted 5/30/2008 12:17 PM (GMT -6)   
I've been on Imuran for over a year. Imuran and 6MP are very similar - it's just how the body metabolizes the drug that's different.

I was freaked out about starting this drug - but after some research and a frank talk with my doc, I decided the side effects that were possible weren't any worse than those of prednisone. I haven't had any issues with Imuran, besides some fatigue. Be prepared for regular blood work after starting 6MP.

The side effects are few and far between. Most of those you'll read about online are from people using the drugs for anti-rejection after an organ transplant. For IBD, the doses are much, much lower.
Pan-colitis and GERD diagnosed May 2003
Osteopenia diagnosed Feb 2006
Status:  Getting close to remission!?!?!
Asacol 12 per day,  Azathioprine 100mg, Aciphex, Forvia, and Pro-Bio
Last dose of pred: May 25
Co-Mod for the UC forum:  Keep HealingWell running smoothly:  www.healingwell.com/donate

Regular Member

Date Joined May 2008
Total Posts : 47
   Posted 5/30/2008 2:04 PM (GMT -6)   
I was allergic to the Sulfasalzine as well. I was on 6mp for about 6 months and was doing really well, I then developed pancreatitus and had to go to the hospital. I was in remission during the time I was taking it and i felt great! You never know until you try it, everyones different. Good luck!
20. Female. California.
Diagnosed left sided Ulcerative Colitis at 15, first symptoms at age 11.

40mg prednisone daily. (currently flaring)

Multi Vitamin
Digestive Advantage Chrons and Colitis
Iron Supplement

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