Remicade has worked well with me. However, it is very expensive. Luckily, I have good insurance. I was allergic to all the other meds and started Remicade. I now go to the bathroom about 8 times a day and have significantly less pain and no blood in the stool.
Because of my young age and fast metabolism, I receive double the normal dose...I think I get 10 mg/kg...not sure though. Typically, after an infusion I feel kinda weak like have a cold for a few days. I can deal with a few days of feeling bad to be relatively healthy for two months.
Everyone's experience with medications is different, but I still highly recommend Remicade. It's worked well with me.
A word of warning though. Beware infections like Staph or the flu. Since I've been on Remicade, I've had both and they've lead to hospital trips because I got so sick. You just have to remain vigilant and proactive in taking care of your body.
Good luck to you and your wife.