article on TNF blockers and cancer

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hana24
Regular Member


Date Joined Dec 2007
Total Posts : 354
   Posted 6/4/2008 11:50 AM (GMT -6)   
http://www.reuters.com/article/governmentFilingsNews/idUSN0431255120080604
Jessica 26/F 40mg pred taper
dicyclomine 10Mg before bed
Citalopram 20 MG
Colazal 3X3/day
Culturelle once daily
omeprazole(for acid reflex)
Tried (Entorcort EC 9ml/day and Prednisone, Asacol)


ediekristen
Veteran Member


Date Joined Apr 2007
Total Posts : 1366
   Posted 6/4/2008 12:02 PM (GMT -6)   
Man. The decisions we have to make with this stupid disease. Risk cancer of the colon, or take drugs to supposedly reduce the risk that increase the risk of other cancers and conditions, or have major life altering surgery and be cured of UC but have a new set of obstacles and possible complications. Meh.
Female, 22, Ulcerative colitis (pancolitis) since 1999; GERD; gastritis; osteopenia in hip & lumbar region of the spine from long term prednisone use.

Current Meds:
10mg Lexapro (for depression/social anxiety)
Digestive Advantage: Crohn's and Colitis formula (2 pills per day, started 5/14/08)
125mg Azathioprine
4800mg Asacol (Four 400mg tablets, three times a day)
 
 
 


bookworm21
Veteran Member


Date Joined Mar 2008
Total Posts : 1766
   Posted 6/4/2008 2:13 PM (GMT -6)   
UC wouldn't be as bad if most of the meds didn't have horrible side effects. ARGH, I don't want to take oral steroids or immunosuppressants or have surgery, but those look like my only options!
Female, Age 19, Dx w/ UC August 2007
Seasonal allergies
9 Asacol/day, 1000 mg Canasa, Proctofoam, Rifaximin 2/day
Digestive Advantage (Crohn's & Colitis) 3 pills/day, 1 Florastor/day
1 DanActive/day


jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10407
   Posted 6/4/2008 2:40 PM (GMT -6)   
Yet more support for stopping the immunosuppressants if you're taking Remicade. Seems you need to pick one or the other. I'd be interested to see something that reports the actual incidence compared with a similar population that's not taking one of these drugs.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Avascular necrosis in both shoulders is my "forever" gift from steroid therapy.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.


ediekristen
Veteran Member


Date Joined Apr 2007
Total Posts : 1366
   Posted 6/4/2008 4:04 PM (GMT -6)   
True. I've heard the risk is MUCH higher when you take something ilke azathioprine in addition to Remicade.
Female, 22, Ulcerative colitis (pancolitis) since 1999; GERD; gastritis; osteopenia in hip & lumbar region of the spine from long term prednisone use.

Current Meds:
10mg Lexapro (for depression/social anxiety)
Digestive Advantage: Crohn's and Colitis formula (2 pills per day, started 5/14/08)
125mg Azathioprine
4800mg Asacol (Four 400mg tablets, three times a day)
 
 
 


Ariabob
New Member


Date Joined Jun 2008
Total Posts : 5
   Posted 6/4/2008 4:07 PM (GMT -6)   
I called the FDA today to find out more 'cause I am not going to give up remicade for any amount of money. It has made me human again and I am closing in on the 1 year mark (supposedly after 1yr the chances of developing cancer drop.) They are just looking into the 30 cases of cancer in children from 1998 to 2008.

bookworm21
Veteran Member


Date Joined Mar 2008
Total Posts : 1766
   Posted 6/4/2008 5:14 PM (GMT -6)   
I wonder what ages they mean by "young adult." Because it could mean as young as 13 or as old as someone in their 20's. And this may be a stupid question, but would 5-ASA's be considered immune-suppressing drugs? Or do they mean steriods or other actual immunosuppressants (like Humira + Remicade)?


Female, Age 19, Dx w/ UC August 2007
Seasonal allergies
9 Asacol/day, 1000 mg Canasa, Proctofoam, Rifaximin 2/day
Digestive Advantage (Crohn's & Colitis) 3 pills/day, 1 Florastor/day
1 DanActive/day


jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10407
   Posted 6/4/2008 5:45 PM (GMT -6)   
When they speak of immunosuppressants, they're talking about Imuran (Azathioprine) and 6-MP. Humira, Remicade and related products are referred to as biologicals or anti-TNF drugs. 5-ASA's are anti-inflammatories rather than immunosuppressants.

As has always been reported, the lymphoma occurrance is a small number and almost always in people who are also taking Imuran or 6-MP.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Avascular necrosis in both shoulders is my "forever" gift from steroid therapy.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.


AngelTT
Regular Member


Date Joined Jun 2005
Total Posts : 213
   Posted 6/4/2008 5:57 PM (GMT -6)   
The news tonight said people who used the drugs before the age of 18 I believe. It might have been even younger. My doc has always said that they do not know the long term effects of Remicade and I can't stay on it for too long. Like everyone else I am wondering what the heck I am going to do since they have tried every other medication on me. sad
34 year old female, Diagnosed 5 years ago
Current Meds: Remicade every 6 weeks, Prednisone 20mg, Prevacid, Sustenex, Lialda, Lexapro (anxiety), Synthroid, Iron, vitamin, Fish Oil
Expecting first child 12/08 via gestational surrogate!!!!


hana24
Regular Member


Date Joined Dec 2007
Total Posts : 354
   Posted 6/4/2008 7:53 PM (GMT -6)   
Maybe more information will be released. My mother takes Enbrel for her arthritis. I wonder if that will be approved for UC. She hasn't had any problems with it but this makes me worried.
Jessica 26/F 30mg pred
dicyclomine 10Mg as needed
Citalopram 20 MG
Culturelle once daily
omeprazole(for acid reflex)
Tried (Entorcort EC 9ml/day and Prednisone, Asacol ,colazal)


bbc
Veteran Member


Date Joined Mar 2008
Total Posts : 1580
   Posted 6/4/2008 8:27 PM (GMT -6)   
Melatonin is a natural TNF blocker but I thibk you'd have to take mega doses...

Ariabob
New Member


Date Joined Jun 2008
Total Posts : 5
   Posted 6/5/2008 6:23 AM (GMT -6)   
BBC,
If I took mega doses of melatonin, I would either be sleeping all of the time or none of the time! HEHE :)
Remember to eat crow while they are small. Big feet really hurt going down.

UC - 3 years so far
Remicade every 8 weeks
Asacol 4/3 times a day
Flaxseed
Fossamax
Calcium
Gas-X

Fingers crossed 'cause I am working on being pregnant.


bookworm21
Veteran Member


Date Joined Mar 2008
Total Posts : 1766
   Posted 6/5/2008 8:19 AM (GMT -6)   
Remicade's website pretty much acknowldeges what that article said.
Female, Age 19, Dx w/ UC August 2007
Seasonal allergies
9 Asacol/day, 1000 mg Canasa, Proctofoam, Rifaximin 2/day
Digestive Advantage (Crohn's & Colitis) 3 pills/day, 1 Florastor/day
1 DanActive/day

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