6 MP ??? Any info would be appreciated

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Concerned Wife in WA
Regular Member

Date Joined Jun 2008
Total Posts : 37
   Posted 6/12/2008 12:02 PM (GMT -6)   
confused Hello. Jim just went back to the doctor and they now are trying him on 6MP with the asacol, prednisone and omeprazole. I am just wondering risks vs. symptoms etc. Any info on this would be great. just trying to muddle through the mess
44 y/o Crab Fisherman in Alaska

Diagnosed May 2008
Mesalamine 12 pills daily
Prednisone 40 mg

Taking multiple vitamin supplements, lots of omega 3's and Antioxidants

Elite Member

Date Joined Mar 2003
Total Posts : 10407
   Posted 6/12/2008 3:41 PM (GMT -6)   
Concerned wife, I've never been on 6-MP, but if you do a search for it using the search funtion at the top of the page, you'll likely find several recent discussions.
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Avascular necrosis in both shoulders is my "forever" gift from steroid therapy.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.

Veteran Member

Date Joined Feb 2006
Total Posts : 5698
   Posted 6/12/2008 4:39 PM (GMT -6)   
In the past few years 6mp has been deemed to be a safe drug. Back in the 1990s when I took it the risks were unknown (similar to how Remicade is now). I took 6mp for 2 years and never had any adverse effects, of course it didn't work for me either but that's beside the point.

dx proctitis in 1987
dx UC in 1991, was stable until 1998

1998 started prednisone, asacol, pentasa, nortriptylene, ativan, 6MP, rowasa enemas and suppositories, hydrocortisone enemas, tried the SCD diet, being a vegetarian, omega 3s, flax, pranic healing, yoga, acupuncture, probiotics

2000 lost all my B-12 stores and became anemic

2001 opted for j-pouch surgery- now living life med-free

Veteran Member

Date Joined Mar 2008
Total Posts : 1202
   Posted 6/12/2008 10:22 PM (GMT -6)   
We are on it now, and weening the Pred. Down to 5mg! The key for this drug is to have an enzyme monitored, as there is a special one that breaks down this drug. Without it in sufficient quantity, the drug stays toxic and hurts liver/kidneys etc. That is my very unscientific understanding. It takes many weeks, and sometimes months to build up in your system, so it doesn't help when you are in a flare. Even the testing for it takes two weeks to get processed in the ONE lab in CA that can do it.
So, far, no side affects, and my daughters' level was 191(200 is ideal), so we are crossing our fingers and toes. We are still on 6 Asacol and on a low residue diet, but the Pred is the thing we want off of !
Good luck, K
Daughter,14 diagnosed 1-08 w/ UC .learning from you all.
Rowasa, Asacol, Prednizone 50mg, major flare, Hosp. @U of C, Comers. IV steroid, no food, then low residue, home.
Now, began mp6, beginning taper of Pred, now 45mg, horrible acne, moon face, and fearful of future.
trying probiotics, Omega 3, and keeping up with doc visits.

Bum Deal
Regular Member

Date Joined Jan 2008
Total Posts : 34
   Posted 6/13/2008 3:43 AM (GMT -6)   


I've been on 6MP for a while now, as I was not having much luck getting off steroids with just Asacol as a maintenance drug. They tried me on Azathioprine first, which is a form of 6mp, but I had a reaction to that so they started me on a low dose of 6MP and have been gradually increasing it. It's been a few months but it seems to be doing the job, I'm feeling pretty good at the moment, daily bms are way down on what they were, and i'm putting on some weight, which is good.

The main side effects that are listed which people seem to get if they get any are headaches, fatigue and nausea, though the rest are listed here: http://ibdcrohns.about.com/cs/prescriptiondrugs/p/med6mp.htm (Edit: the link doesn't seem to work automatically for some reason, but if you cut and paste it or type it in it does work.)

I've had no side effects from it other than a few days of mild headaches when they increase the dose (which goes), and a little bit of tiredness - but really nothing that's affecting me greatly, and the benefits I'm getting from the drug far, far outweigh any problems. Hopefully with this stuff I'll be off the steroids soon.

I'm sure your doc will be doing this already, but your husband will need regular bloods monitoring while he's on the 6MP, especially in the first few months, just to make sure his system's dealing with the drug ok.

I hope the change of meds works for your husband, and that he's better soon. It can take a bit of time to see results with 6MP, especially if they're starting on a low dose, but hang in there and hopefully he'll be on the mend soon enough.


Male 30 Years Old.

Diagnosed Pancolitis June 2007

Currently 20mg Prednisolone, 9 tablets Asacol, 50mg Imuran (started Dec 07), 75mg Mercaptopurine (following allergic reaction to Imuran)

Regular Member

Date Joined Jan 2008
Total Posts : 381
   Posted 6/15/2008 10:59 AM (GMT -6)   

I was on 6MP for about 3 months. It really helped- that and the Remicade. The side effects I experienced were fatigue, heavy feeling - like it was hard to move at times- sores and bruises. It was worth it. Actually the prednisone effects were MUCH worse... I hate Prednisone!!!!!!!!!! With 6Mp you do need to get regular blood work, though.



Jackie 42yr. old
Pancolitis - dx Jan. 07
Remicade- 7th infusion June 16th
Lialda 2 tabs
Protonix, Rowasa enemas
Lexapro, Synthroid

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