How do doctors really know if it is UC?

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bellski
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Date Joined Apr 2008
Total Posts : 499
   Posted 6/12/2008 8:22 PM (GMT -6)   
Just curious.  My biopsies showed UC.  My recent flex sig showed no imflamation, (still awaiting those biopsy reports).  Anyhow, I've been wondering, Do UC cells look a certain way?  I heard one person say they were getting a blood test to see if they had UC.  I never had a blood test.  What are your thoughts.  Thanks guys!
Lori (Bellski)-age 43 from Illinois
Diagnosed February 2008 with Ulcerative Proctitis, possible dysplasia
Currently: symptoms have subsided, awaiting biopsy results for dysplasia
Medications:  Asacol 400mg X 6, Cymbalta 20 mg X 1, Canasa (sometimes) Vitamins:  Calcium 600 + D X 2, One a Day Women's X 1, Citrucel, Probiotics
High fiber diet
"I thank God that  I found this website!"
 


djdaz_1985
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Date Joined Jan 2006
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   Posted 6/13/2008 3:11 AM (GMT -6)   

Hiya,

I cant honestly answer your question but I am bumping this up to the top so you get an answer. Unfortunately, I am just helpnig out here for a bit. My expertise is Depression and Epilepsy. I hope someone can answer you though.

Darren


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Silent Lucidity
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Date Joined Nov 2007
Total Posts : 625
   Posted 6/13/2008 5:09 AM (GMT -6)   
I was told there are changes in the bowel wall that indicate UC,as regular Colonoscopies can detect if it's spread,even if remission at the time of the C-Scope.This info came from a qualified GI.Blood test will not show UC,but changes in the blood can be "inflammatory markers".They don't show where the inflammation is,but obviously if you are suspected for UC,and the blood test shows you have inflammation,it's a pointer to UC.

Obviously biopsies taken from the bowel are also used to indicate UC.Those are my understandings,hopefully someone else here will clarify a little more.
Procto-Sigmoiditis dx 1995.First Colonoscopy in ten years,on 29th Feb 2008,revealed moderate to severe Pancolitis.
Current meds;200mg Azathioprine daily.Pentasa 2 x 500mg 4 x daily.
Got Ryche?


bellski
Regular Member


Date Joined Apr 2008
Total Posts : 499
   Posted 6/13/2008 6:49 AM (GMT -6)   
Thanks you very mych for the replies, I appreciate the replies.
Lori (Bellski)-age 43 from Illinois
Diagnosed February 2008 with Ulcerative Proctitis, possible dysplasia
Currently: symptoms have subsided, awaiting biopsy results for dysplasia
Medications:  Asacol 400mg X 6, Cymbalta 20 mg X 1, Canasa (sometimes) Vitamins:  Calcium 600 + D X 2, One a Day Women's X 1, Citrucel, Probiotics
High fiber diet
"I thank God that  I found this website!"
 


jujub
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Date Joined Mar 2003
Total Posts : 10407
   Posted 6/13/2008 7:16 AM (GMT -6)   
The biopsies taken when they do your colonoscopy are the most definitive diagnostic tool, but are used in conjunction with blood tests for what are called "inflammatory markers," stool tests to rule out infection and parasites, and your description of your symptoms. Usually colonoscopy is at the end of this process, when other causes have been eliminated and the doctor knows we're looking for some kind of colitis, most likely UC or Crohn's.

I'm not a pathologist so I can't tell you exactly how the cells change, but the cells in the wall of the intestine change when IBD is present. I do know that in UC only the inner layers of cells are affected, while in Crohn's the whole thickness of the intestinal wall can be affected. Occasionally they will find cell pathology that looks like UC, but with a patchy distribution in the colon that looks like Crohn's. In this case the diagnosis may be "indeterminate" colitis.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Avascular necrosis in both shoulders is my "forever" gift from steroid therapy.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
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Please remember to consult your health care provider when making health-related decisions.


love4cats
Regular Member


Date Joined May 2007
Total Posts : 458
   Posted 6/13/2008 7:22 AM (GMT -6)   
My GI's did not do a definite diagnosis until after the colonoscopy and the biopsy results came back so there must be something in the cells of the colon that indicate UC.
 
 
Dx:  UC Proctitis 2006 
Meds:  None so far. Garlic works to ease flares. My GI laughed when I told him and said it was just coincidence. 
Started Meds:  Apr 9 08 500mg 5ASA (salofalk) to ease flare, tapering, stopped. 
Diet:  Regular fresh garlic, Biobest yogurt daily, Omega 3 supplements, very limited junk food, carbs and processed food, low fat diet.  Lots of fresh fruit and veggies (limited potatoes). 
 Added: tumeric and probiotics.
 
 


bellski
Regular Member


Date Joined Apr 2008
Total Posts : 499
   Posted 6/13/2008 7:25 AM (GMT -6)   
Thanks Judy. When I went in for my colonoscopy, it was at my request, I just called the doctor and said I had bleeding and that I wanted a colonoscopy and he ordered it. I suspected something simple like internal hem. That is probably why I never had the blood or stool testing done. I skipped right to the scope. However, now I am wondering if my doctor is being thorough enough. Do you think bloodwork and stool samples should have been done? Just curious, any advice will help. Bellski
Lori (Bellski)-age 43 from Illinois
Diagnosed February 2008 with Ulcerative Proctitis, possible dysplasia
Currently: symptoms have subsided, awaiting biopsy results for dysplasia
Medications:  Asacol 400mg X 6, Cymbalta 20 mg X 1, Canasa (sometimes) Vitamins:  Calcium 600 + D X 2, One a Day Women's X 1, Citrucel, Probiotics
High fiber diet
"I thank God that  I found this website!"
 


seconder
Veteran Member


Date Joined Jun 2008
Total Posts : 610
   Posted 6/13/2008 7:28 AM (GMT -6)   
If I'm not mistaken, the biopsy will look for crypt cell abnormalities (abcesses etc.) consistent with ulcerative colitis.

kb5
Veteran Member


Date Joined Jan 2007
Total Posts : 1015
   Posted 6/13/2008 7:32 AM (GMT -6)   
My original dx was done by flex sig only. It wasn't until months later that i had a full scope and bloodwork. But i was bleeding very heavily at the time and in pretty bad shape. i don't think they wanted perforation with a full scope at the time.
Kelly, 30

Left sided UC diagnosed 1/98 age 19, Pan colitis diagnosed 1/07
Currently on 4x3 Asacol, no more pred after two years!!!! Off imuran as remicade is working!
Prontonix once daily for acid reflux, zofran 8mg every six hours for nausea
Remicade started 3/1/08...just had 4th infusion


PeanutMom
Regular Member


Date Joined Jun 2008
Total Posts : 197
   Posted 6/13/2008 7:54 AM (GMT -6)   
when I was diagnosed it was colonoscopy with biopsy and they gave me pictures with an explanation of what was being shown. Mild -moderate was explained to me in layman's terms as resembling a regular body rash except it's internal not external and the "rash" isn't raised it's the tiny ulcers. The more involved it is the more swollen things become ie the more pain you end up with. The biopsy confirmed the visuals for them.

That's the way it was presented to me, don't know if that helps. It always helped me to relate new issues to something I was familiar with.

jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10407
   Posted 6/13/2008 7:54 AM (GMT -6)   
Since your scope showed no inflammation, you may want to just wait for the scope report. Infections and parasites usually show inflammation. I would think the doc could also tell you from the exam if you have hemmies or a fissure that could be causing the blood.

Not to scold, but be sure you get your colonoscopies done regularly from now on. Most docs recommend every one to two years after you've had UC for ten years, to monitor for any dysplasia.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Avascular necrosis in both shoulders is my "forever" gift from steroid therapy.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.


Chris'sColon
Regular Member


Date Joined Jun 2008
Total Posts : 237
   Posted 6/13/2008 8:03 AM (GMT -6)   
I'm confused too. my cousin's infant was also diagnosed with something similar to UC (his mom was calling it UC but it was actually an allergic reaction to her breastmilk and not permanent) it acted/looked like UC in that his colon was ulcerated and they treated it like UC with prednisone and Pentasa for a while. but it eventually went away and is not expected to re-present. so i just wonder how they tell the difference.
Veronica (26), mommy to Chris (2.5 yr old, diagnosed november 2007 with left sided UC) and Emily 2.5 months
 
Chris current meds: Pentasa 250mg 3x's daily
currently in remission


bellski
Regular Member


Date Joined Apr 2008
Total Posts : 499
   Posted 6/13/2008 8:09 AM (GMT -6)   
I will, the doc didn't find any hemmies. He found uc....yeah. If this biopsy comes back no dysplasia and if I don't have any symptoms, he said he wants to do another flexsig in one year. I suppose the flex sig is almost as good as a colonoscopy but the colonoscopies will be spaced out more. I do appreciate all of the replies, thanks!
Lori (Bellski)-age 43 from Illinois
Diagnosed February 2008 with Ulcerative Proctitis, possible dysplasia
Currently: symptoms have subsided, awaiting biopsy results for dysplasia
Medications:  Asacol 400mg X 6, Cymbalta 20 mg X 1, Canasa (sometimes) Vitamins:  Calcium 600 + D X 2, One a Day Women's X 1, Citrucel, Probiotics
High fiber diet
"I thank God that  I found this website!"
 


PeanutMom
Regular Member


Date Joined Jun 2008
Total Posts : 197
   Posted 6/13/2008 11:59 AM (GMT -6)   
Judy - every 2 years? My GI was telling me every 5 years. . . . should I be concerned? I did have a bit of an explosion with him last year so I'm wondering if he's not paying as close attention to me because of it.
Kim ~ Mom of Nathaniel aka "Peanut" 18months old
========================
I'm a married 36 yr old mom and here's "The list "
- UC 1997 currently unmedicated was on Colozal from 2001-2007
- Stage 3 CKD (Chronic Kidney Disease) 2007 taking 7.5mg lisinopril
- Anemic - Ferolicit IV bi-weekly
- Ashermans Syndrome - no treatment
- Allergies - water - haven't been tested officially but pine suspected

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