Long term prednisone, anything to protect the stomach? Help!

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Regular Member

Date Joined May 2008
Total Posts : 47
   Posted 6/14/2008 1:36 AM (GMT -6)   
Ive been on prednisone for what seems like forever and this time around my stomach really really hurts. Its nothing like the lower cramping that comes with UC. It comes in episodes, and its been getting worse. It started happening after the prednisone kicked in and stopped the bleeding. My friends mom has lupis and has been off and on prednisone for years. She said her mom developed stomach ulcers and really bad acid reflux after prolonged use and said that she believed her mom took something to protect her stomach. She didn't know what it was though.

Im scheduled for a colonoscopy and endoscopy in a few weeks, the doctor said since Ive been on prednisone for so long I should do an endoscopy too. I dont really know why. I called today and asked if theres anything I can do because these stomach aches wake me up at night and are effecting me at work. Of course since its Friday, I won't be hearing from the doctor until Monday. I'm miserable, any advice helps!
20. Female. California.
Diagnosed left sided Ulcerative Colitis at 15, first symptoms at age 11.

40mg prednisone daily. (Been on prednisone 5mg-40mg for the past year)
Now down to 30mg

Multi Vitamin
Digestive Advantage Chrons and Colitis
Iron Supplement
Allergic to- 6mp, Asacol

Regular Member

Date Joined Oct 2007
Total Posts : 320
   Posted 6/14/2008 3:04 AM (GMT -6)   
Food is pretty much the only thing you can use to protect your stomach when taking prednisone. I hope you have always taken your pred after a full meal.

To settle your stomach you can try warm milk, and if you need something a little more hardcore, you could try an over the counter antacid and see if either of them help.

The endoscopy is a very good idea. Will help find out if there is a physical problem in your stomach such as ulcers and if so, allow them to take a biopsy and work out if its the kind they can treat or not.

You might also want to consider that the cramps may be the result of sodium, magnesium or zinc deficiency.
"We are dreamers, shapers, singers and makers..." - Elric, Technomage
  • 28yo male. Brisbane, Australia. Diagnosed at 16yo. Currently enjoying severe pan-colitis.
    - Participating in the Golimumab trial as of 1st May, 2008;
    - 2x Colazide, twice a day; 25mg of 6-MP a day; 1xAllopurnol;
    - 1x teaspoon of Metamucil 3 times a day;
    - 1x BIOCeuticals UltraBiotic 45 + 1x SB FlorActiv twice a day.

Regular Member

Date Joined Jun 2008
Total Posts : 237
   Posted 6/14/2008 8:51 AM (GMT -6)   
when my son was on prednisone his Dr also prescribed prevacid to be taken about 30 mins before the pred to protect his stomach.
Veronica (26), mommy to Chris (2.5 yr old, diagnosed november 2007 with left sided UC) and Emily 2.5 months
Chris current meds: Pentasa 250mg 3x's daily
starting to flare

Elite Member

Date Joined Mar 2003
Total Posts : 10407
   Posted 6/14/2008 10:30 AM (GMT -6)   
The endoscopy is definitely needed to see if you have prednisone-induced ulcers in your stomach.

I hate like heck to tell you this, but after a year on Prednisone, stomach ulcers could be the least of your worries. It's important for you to have your bone density checked to be sure you haven't developed osteoporosis. You also need to have a good eye exam to look for eye complications.

I hope you're tapering off the Pred for good. I see that you have some drug intolerances, but there are other drugs available now that are much less likely to cause major side effects than prednisone. It is never intended to be a maintenance drug.

Good luck, and let us know how it turns out.
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Avascular necrosis in both shoulders is my "forever" gift from steroid therapy.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.

New Member

Date Joined Jun 2008
Total Posts : 15
   Posted 6/14/2008 11:24 AM (GMT -6)   

Hi, I to have similar probs taking pred, it plays havoc with my stomach.My docter put me on Omeprazole 20mg capsules to take before i take the pred and it has been a life saver.

Hope you find the answer to your problem! good luck.xxxxxxx :-)

Veteran Member

Date Joined Apr 2006
Total Posts : 3402
   Posted 6/14/2008 8:19 PM (GMT -6)   
I agree with what Judy said.

In the mean time - maalox liquid will soothe the burn.

Start a calcium supplement ASAP if you're not already on one.
Pan-colitis and GERD diagnosed May 2003
Osteopenia diagnosed Feb 2006
Status:  Flaring
Asacol 12 per day,  Azathioprine 100mg, Aciphex, Forvia, and Pro-Bio
30mg Pred until I get set up for Remicade
Co-Mod for the UC forum:  Keep HealingWell running smoothly:  www.healingwell.com/donate

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