Sulfasalazine manufacture difference?

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IndianaUC
Regular Member


Date Joined Feb 2007
Total Posts : 212
   Posted 6/16/2008 3:17 PM (GMT -6)   
I was taking Asacol and then lost my insurance. My GI then prescribed me Sulfasalazine because it was cheaper. I got it at the local drug store and started doing better. I started price checking around and found one pharmacy on the cheaper prescription list and went to get that. The tablets look different. Since I've been taking those over the past few months my colitis seems to have gotten worse. I know they are not supposed to be chemically different, but could it really be possible? Could the previous version actually be different? confused
- DXed with "left sided" UC in 1998. DXed with "proctitis" Oct. 2007
- Sulfasalazine 4 500mg tabs twice daily
- 500mg Vitamin C, 1 Multivitamin, L-Glutamine
- Max Acidophillis EC Capsules 350Mg(7 types of bacteria with over 42 billion viable cells) with 50 Mg colostrum & 50 Mg FOS(fructo-oligosaccharides)
- Experimenting with this or that on occasion. Always open to new ideas.


jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10407
   Posted 6/16/2008 4:24 PM (GMT -6)   
Sulfasalazine is sold as a generic, and manufactured by numerous pharmaceutical companies. Different companies use differing binding ingredients, etc. Therefore, while the active ingredient is the same, the "inactive" ingredients may be different. If you happen to be intolerant of one of the inactive ingredients, it can cause issues like this. I'd suggest going back to the original, then after a few weeks see if you have improved.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Avascular necrosis in both shoulders is my "forever" gift from steroid therapy.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.


potty girl
Veteran Member


Date Joined Dec 2006
Total Posts : 835
   Posted 6/16/2008 5:37 PM (GMT -6)   
I agree with Judy there is alot of generic meds I cant take due to haveing a allergic reaction to them but I can take the brand name. Go figure you would think they would be the same. But most of them have different fillers.
Rona

synthroid .088 mg, lowpressor 50 mg x 2, cozaar 25mg x2, imdur 30 mg
nitroquick, proventol, plavix 75 mg, protonix 40 mg x 2, asacal 400mg x 9
carafate 1 gm x 4, zyrtec 10 mg, rhinocort aqua nose spray, fish oil,
potassium.


rdm
Regular Member


Date Joined Apr 2006
Total Posts : 229
   Posted 6/16/2008 6:47 PM (GMT -6)   

This is a tricky area.  For years I refused to take the generic (I have been on this drug for over 20 years) as when I did the results werent good. Eventually a pharmacist told me one of the generics was made by the same company as made the original (azulfidine) I tried it and it seemed fine. I dont remember the brand but some with some Goggoling or asking of a phamacist you can probably find it. It was the same drug, same process but dfferent name. I have since been on another generic for the the past 4 years and it seems fine, called Sulfazine. It is very cheap I get 3 months worth for under $75 but this is through my health insuance company even though I have no drug coverage it is discounted.   It may be that the active ingredient in all the generics is the same but the fillers may be different and cause poor results or the active ingrediants may vary somewhat. You could try Azulfidine and see what happens. it costs, as I recall at least double the generic.


munchkindd
Regular Member


Date Joined Oct 2007
Total Posts : 348
   Posted 6/16/2008 6:58 PM (GMT -6)   
There are 2 different types of these. There are the regular 500 mg yellow, round pills (uncoated). Then there are also the enteric coated ones (en tabs) which are time released. If you are taking the en tabs, they may not be breaking down, and therefore may not be working. Do you notice any in your bm's that have not been dissolved? I had this problem with the Asacol, they were coated and not breaking down in my gut, therefore they weren't working for me. (that's my guess as to why they weren't working) I am on the regular round, yellow or gold 500 mg. ones. Which ones are you taking now? Does your paper work from the pharmacy say EN TABS?
*******Donna*******
 
diagnosed with uc 27 years ago.  Enojoyed 20 year remission with just minor blips here and there (approximately 16 of those years without any meds)
 
In a flare for 2 very long years which Asacol didn't help at all.  Finally in remission again since Jan 2008, can't believe it..............
 
currently on Sulfasalazine 2 tabs 3x day. Folic acid, mesalamine enema 2 x a week. Omega 3, Probiotics, multi vitamin, calcium supplement, Biotin....
 


munchkindd
Regular Member


Date Joined Oct 2007
Total Posts : 348
   Posted 6/16/2008 7:38 PM (GMT -6)   
If you look on the walgreens.com website, you will see a photo of the en tabs, they are oval shaped. I don't know if that goes for all brands of the azulfidine en tabs. Hope this helps......
*******Donna*******
 
diagnosed with uc 27 years ago.  Enojoyed 20 year remission with just minor blips here and there (approximately 16 of those years without any meds)
 
In a flare for 2 very long years which Asacol didn't help at all.  Finally in remission again since Jan 2008, can't believe it..............
 
currently on Sulfasalazine 2 tabs 3x day. Folic acid, mesalamine enema 2 x a week. Omega 3, Probiotics, multi vitamin, calcium supplement, Biotin....
 


IndianaUC
Regular Member


Date Joined Feb 2007
Total Posts : 212
   Posted 6/17/2008 5:48 AM (GMT -6)   
I checked Walgreens.com. I didn't know they had pictures. Thanks that does help alot. I used to take these from Pfizer: http://www.walgreens.com/library/finddrug/druginfo1.html?particularDrug=Azulfidine&id=12754 and I found that Kmart sold them cheaper, but what I didn't know was that they were from a different maker as seen here: http://www.walgreens.com/library/finddrug/druginfo1.html?particularDrug=Sulfasalazine&id=639268

What bothers me the most is that there can be such a drastic difference. The original RX pills were much more tightly formed and flatter. The Watson Labs ones are a tad bigger and leave a yellow/gold stain on my hands.

Reguardless these pills seems to completely break down in my body unlike the Asacol that I used to take. Most of them would pass right through me and I would find them...in the pool...so to speak. Also towards the end of my taking them they were causing panic attacks. That's why I finally told the doc that I needed something else. I've been living with this for 10yrs and for most of that time I never had any symptoms. I never took a single pill.
- DXed with "left sided" UC in 1998. DXed with "proctitis" Oct. 2007
- Sulfasalazine 4 500mg tabs twice daily
- 500mg Vitamin C, 1 Multivitamin, L-Glutamine
- Max Acidophillis EC Capsules 350Mg(7 types of bacteria with over 42 billion viable cells) with 50 Mg colostrum & 50 Mg FOS(fructo-oligosaccharides)
- Experimenting with this or that on occasion. Always open to new ideas.


munchkindd
Regular Member


Date Joined Oct 2007
Total Posts : 348
   Posted 6/17/2008 6:01 AM (GMT -6)   
The manufacturer name on my bottle is Greenstone Ltd.
*******Donna*******
 
diagnosed with uc 27 years ago.  Enojoyed 20 year remission with just minor blips here and there (approximately 16 of those years without any meds)
 
In a flare for 2 very long years which Asacol didn't help at all.  Finally in remission again since Jan 2008, can't believe it..............
 
currently on Sulfasalazine 2 tabs 3x day. Folic acid, mesalamine enema 2 x a week. Omega 3, Probiotics, multi vitamin, calcium supplement, Biotin....
 

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