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pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 6/16/2008 4:07 PM (GMT -6)   
Does Lialda stop the urges and frequency issues? Do you get full bowel control back, like when you have to "go" you can control it if you're not close enough to the toilet, because currently my issues are still those 2 things, when I have to go it's immediate and although I am doing better frequency wise (usually 5/day, except during my periods then it can be much more) I'd like to know if Lialda combats that issue as well and does it help during the times of mensturation when things tend to get worse.

Any experiances anyone has with these issues that you can share would be greatly appreciated....although I'm not sure if it would be an option for me because imuran never worked for me in the past.

:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


auntmoo
Regular Member


Date Joined Dec 2006
Total Posts : 43
   Posted 6/16/2008 4:14 PM (GMT -6)   
Hi, I believe Lialda is my miracle drug.  I tried the heavy hitters and they made me sick.  I switched to Lialda and after a few months I feel much better.  Not sure if the Lialda stopped the urgency or the combination of that and predisone but
so far so good.  I have been taking it for almost a year now, with about once every two weeks or when too much stress in my life, the enemas.

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 6/16/2008 4:40 PM (GMT -6)   
Are you still taking pred with it, or Just the Lialda by itself?

Thanks :)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


relativelyquantum
Regular Member


Date Joined Sep 2007
Total Posts : 196
   Posted 6/17/2008 12:06 AM (GMT -6)   
I've been taking 2 Lialda/dy and the low residue/impact diet for a couple weeks now and I believe I am doing a little better. I want to take 4/dy to see if that would push me into remission. For some reason my GI thought 2/dy was the max, so I printed out something online to show him otherwise. This was all through his assistant and because of insurance stuff, I will be seeing the other GI in the office and will ask him about upping the dosage. Probably a good thing to try someone else at minimum for a second opinion.

Not that you needed all the information, but I did learn something interesting the other day. If I understood correctly, certain 5-ASAs release with acid, some at the stomach, but others like asacol and lialda are near the end of the small intestine/beginning of the colon. However, others are released by bacteria and tend to be further down the colon, like colozal. I got this from a small conference at UCI several days ago and if I can think/compile a few more useful facts from it, I will post them. I like the idea of Lialda because it is a gradual release. One of their reps had told me there is some sort of gel like substance covering it that is supposed to be soothing or whatever. If anything, once a day makes it really nice.
Pancolitis '04
Mild flare
Taking Rowasa, Probiotics, Fish Oil, Folic Acid, Alpha Lipoic Acid, Iron


AngelTT
Regular Member


Date Joined Jun 2005
Total Posts : 213
   Posted 6/17/2008 6:22 AM (GMT -6)   
I haven't noticed a big difference being on the Lialda but everyone is different. What works for some may or may not work for others. It's definitely worth a try based on what others have said about it.

34 year old female, Diagnosed 5 years ago
Current Meds: Remicade every 6 weeks, Prednisone 10mg (tapering), Prevacid, Sustenex, Lialda, Lexapro (anxiety), Synthroid, Iron, vitamins, Fish Oil
Expecting first child 12/08 via gestational surrogate!!!!


hana24
Regular Member


Date Joined Dec 2007
Total Posts : 354
   Posted 6/17/2008 6:59 AM (GMT -6)   
I've been on the Lialda for about two weeks but I am still on the pred at 20 mg so I can't tell if it is helping. It isn't giving me any problems. I told the doctor I don't mind taking the asacol 3 times a day if he thought it would work better but he says to try this. The coating is different and the pills are bigger so maybe it will help me. The asacol didn't really seem to do anything at all and the colazal made me worse....


It seems to me that maybe if you could get your inflammation completely down first then the 5-asa's might work better to keep you without inflammation. I feel like they help me stay better but once I get bad they are just a drop in the bucket. That's just me trying to read my body - I have nothing to back that up.
Jessica 26/F 30mg pred
dicyclomine 10Mg as needed
Citalopram 20 MG
Culturelle once daily
omeprazole(for acid reflex)
Tried (Entorcort EC 9ml/day and Prednisone, Asacol ,colazal)


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 6/17/2008 9:27 AM (GMT -6)   
Thanks guys for sharing...I guess it's something to ponder anyways...I know when I was on Asacol after taking the first dose of I believe 4 pills a couple hours went by and I broke out into a full body rash with severe nausea and the chills & sweats...so I'm not sure if Lialda is necessarily an option for me or not but I wanted to enquire with those who have experiances with it.

:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


Alycacc
Regular Member


Date Joined Jun 2008
Total Posts : 46
   Posted 6/17/2008 10:01 AM (GMT -6)   
I know Lialda has the exact same molecular formula as Asacol.  The only difference is that it's a stronger dose per capsule (1.2 grams vs 400 milligrams).  So it's more of a convenience factor more than anything...for example,  I would take 4 Lialda tabs per day vs. 12 tabs of Asacol..If you are breaking out in a rash with Asacol, you will most likely experience the same with Lialda.  As always, consult with your dr.

PeanutMom
Regular Member


Date Joined Jun 2008
Total Posts : 197
   Posted 6/17/2008 10:12 AM (GMT -6)   
When I took Asacol I had no reaction . . nothing got better nothing got worse. a year later I went on Colazal and things got better quickly but then after I think it was 6 years on it and having a baby my body seemed to not like colazal anymore. I'm currently on nothing but still have frequency and urgency (just not as bad as when on colazal) I would love to tame this, do you think that the extra boost in Lialda might work or probably not since asacol didn't work 8 years ago?

I do know to go to the Doc I just was curious of opinions and if anyone had a problem with adapting to one med and then the other working when it didn't before.
Kim ~ Mom of Nathaniel aka "Peanut" 18months old
========================
I'm a married 36 yr old mom and here's "The list "
- UC 1997 currently unmedicated was on Colozal from 2001-2007
- Stage 3 CKD (Chronic Kidney Disease) 2007 taking 7.5mg lisinopril
- Anemic - Ferolicit IV bi-weekly
- Ashermans Syndrome - no treatment
- Allergies - water - haven't been tested officially but pine suspected


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 6/17/2008 11:16 AM (GMT -6)   
Thanks Alycacc :)

That's kinda what I was wondering and you're probably right in that I'll probably have the same allergic reaction.

Oh well, my hopes are still in the stem cell approach...I just wish that would speed up on the horizon of taking care of IBD.

:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


Harpo
Regular Member


Date Joined Jul 2007
Total Posts : 262
   Posted 6/17/2008 12:07 PM (GMT -6)   
Lialda seems to work for me..

If you try it, keep in mind it can take months to see the benefit..
Male 36yrs old. Indeterminate Colitis 6 yrs.


Pro-bio

Protonix
multi vitamin


bookworm21
Veteran Member


Date Joined Mar 2008
Total Posts : 1766
   Posted 6/17/2008 12:14 PM (GMT -6)   
I just switched to Lialda from Asacol a couple days ago. Even after Remicade and 5-ASA switch, I'm still having my usual flare symptoms.
 
I agree, pb4--we need a cure ASAP!
Female, Age 19, Dx w/ UC August 2007
9 Asacol, Rowasa1000 mg Canasa, Proctofoam, Rifaximin 2/day
Digestive Advantage (Crohn's & Colitis), 1 Florastor, 50 mg 6MP,1 Primadophilus reuteri, 1 DanActive, Remicade (1st infusion 06/08), 2.4 g Lialda


Alycacc
Regular Member


Date Joined Jun 2008
Total Posts : 46
   Posted 6/17/2008 1:17 PM (GMT -6)   
Unfortunately, I had all of the same side effects/allergic reactions with the Lialda as I did with the Asacol. My dr. immediately took me off b/c I was experiencing about 41 side effects:( I felt like I was dying... Ask you dr. about it...Good Luck:)

fitmom00
Regular Member


Date Joined Mar 2008
Total Posts : 113
   Posted 6/17/2008 5:35 PM (GMT -6)   
I take 4 Lialda a day. Doc told me that's the max dose, I'd definitely revisit that with him. I don't have anything to compare it to, as that's what I've always taken, but it seems to do the trick for me. I was in remission for about 6 months and have been in a flare for about 3-4 months, but am on the road to recovery now.
Renee
Diagnosed w/ UC in August 2007
Current status: Flare

4 Lialda/day, steroid enema at night, Wellbutrin XL


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 6/17/2008 5:38 PM (GMT -6)   
I'm glad for all of you that are finding it helpful and sorry for those who are not...one day a cure will come and hopefully we will all benefit and living long enough for that day.

:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


AlabamaBabs
Regular Member


Date Joined Jul 2007
Total Posts : 172
   Posted 6/17/2008 7:32 PM (GMT -6)   
Hi Pb4--I've been on Lialda for more than a year and started with 2 pills/day and have been on 4 for awhile.  I was having some flare symptoms that I used Canasa for, but have been symptom free for awhile (since I last posted here).  I still take the 4/day.  I stopped having urgency within a month or less of taking Lialda.  I love it!  Pancolitis no longer dominates my life!  I am now focusing on weight loss and eating all the fruits and veggies with skin that I can along with lean proteins and plenty of carbs, too.  Still, no urgency or need "to go."  I have up to 2 bms per day that are formed, although the more fiber I eat, the more I go, but nothing at all compared to what things were like in last year!   Have you talked to your doc about Lialda?  Let us know how it goes!!

AlabamaBabs
Pancolitis diagnosed 5/07 and started 2 Lialda/day;
increased to 4 Lialda/day since 8/01/07
Started 40 mg. Prednisone on 9/16/07 and DONE as of 11/26/07!Canasa suppositories 1000mg as needed
 


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 6/17/2008 8:17 PM (GMT -6)   
AlabamaBabs :)

I was gonna be it seems pointless now because I know I'm severely allergic to asacol.

I eat fibre daily as well and take fibre supplements daily too (as instructed by my GI)...and it has helped tons with formation and cut back of daily BM's, I was just looking for that little extra to take the edge off of urgency and frequency.

:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


Felinis
New Member


Date Joined Jun 2008
Total Posts : 4
   Posted 6/18/2008 8:57 AM (GMT -6)   
Asacol and Lialda contain the same drug.

Asacol is:
1. Off-patent so it is available in generic form.
2. You may have to take as many as eight pills throughout the day.
3. Costs $1 per pill (50 cents in Canada).

Lialda is:
1. Patented since it uses a different slow-release method.
2. Larger so that you can take half as many pills.
3. You MAY only need to take it once per day.
3. Costs $5 per pill.

Lialda is typical of the ploy that drug firms use to keep drug costs maximized. The scenerio goes like this:
A drug goes off patent and the price of its generic version plunges.
A drug company invents some enhancement to the medication (like a different delivery system),
that will allow them to re-patent the same drug.
The "new and improved" medication is released with tremendous fanfare and your physicians are instructed to push it.

There are hundreds of announcements of the FDA approval of Lialda on the Internet. Just perform a web-search.
You will find that each ad states that Lialda was found to be more effective than placebo.
But nowhere will you find a study or even discussion of the effectiveness of Lialda against the cheaper Asacol.

The pharmaceutical companies and their physician stooges depend upon three things to get you to go for the more expensive treatment:
1. That you are new to IBD and that you are ignorant of Asacol.
2. That you are so desperate to end your flare-up symptoms that you will try anything, no matter what the cost.
3. That you won't notice that Lialda costs $600/month because you only pay $75 and your insurance will pick up the rest.

The choice is yours.

Post Edited (Felinis) : 6/19/2008 7:51:51 PM (GMT-6)


seconder
Veteran Member


Date Joined Jun 2008
Total Posts : 610
   Posted 6/18/2008 5:35 PM (GMT -6)   
If I'm not mistaken, the patent on Asacol hasn't expired yet, but that doesn't completely invalidate your point, and your general point is true enough: Drug companies seek to extend their patents by tweaking their formulas.

Besides, Asacol is a Proctor & Gamble product; Lialda is made by. . . Shire.

bbc
Veteran Member


Date Joined Mar 2008
Total Posts : 1580
   Posted 6/18/2008 6:03 PM (GMT -6)   
Sometimes the time release mechanism (MMX in Lialda's case) does not work as well as taking Asacol more frequently throughout the day...

Felinis
New Member


Date Joined Jun 2008
Total Posts : 4
   Posted 6/18/2008 6:21 PM (GMT -6)   

Seconder:

You may be correct, however there are generics anyway.  Go figure.

The talk on the Internet is divided between those who say that Asacol has gone off-patent, will soon go off-patent and those who say that it goes off-patent in 2013.

Regardless of its patent status, it is cheap(er) and effective.  My Crohn's Colitis was treated with it for years until my blood counts inexplicably went awray.  The cause was never determined.

I was then put on Colazal.  I remained healthy, but my stools became loose and un-formed.

My last colonoscopy biopsies in May 2008 revealed "no indication of disease" (yea!) yet I was placed on high doses of Lialda - at $5 per pill!  And I am not even sick!  My flare-ups come once every 10 years.

There is obviously a BIG push of Lialda by the GI department of my medical center.  When I called to complain about the price and to request Asacol again,  even the secretary tried to push Lialda on me by tempting me with 3-month discount cards on Lialda.

I have been an IBD sufferer since 1992, so I believe that I know what I am talking about when I say the Lialda's "improved" delivery system is just a thin excuse for its outragous cost.

Post Edited (Felinis) : 6/19/2008 7:54:28 PM (GMT-6)


FitzyK23
Veteran Member


Date Joined May 2005
Total Posts : 4219
   Posted 6/18/2008 6:53 PM (GMT -6)   
Now pentasa worked for me and Asacol didn't. Is Lialda more like Asacol or Pentasa and what is the difference? I was under the impression that the release mechanisms were different but for GI patients that is VERY important. Pentasa is released where I need it, Asacol is released in a different part of the intestine where I don't have problems. So if Lialda and Asacol are released differently and one is released where your IBD is and the other isn't you might actually see a difference.

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 6/18/2008 6:59 PM (GMT -6)   
From my understanding asacol is released in the large intestine (colon) but apparently immuran releases in the small and the large which is weird to me because I thought it only released in the large as well.

:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


bbc
Veteran Member


Date Joined Mar 2008
Total Posts : 1580
   Posted 6/18/2008 9:36 PM (GMT -6)   
Felinis said...

You may be correct, however there are generics anyway.  Go figure.

The talk on the Internet is divided between those who say that Asacol has gone off-patent,

will soon go off-patent and those who say that it goes off-patent in 2013.

Regardless of its patent status, it is cheap(er) and effective.  My Crohn's Colitis was treated with it for years until my blood counts inexplicably went awray.  The cause was never determined.

I was then put on Colazal.  I remained healthy, but my stools became loose and un-formed.

My last colonoscopy biopsies in May 2008 revealed "no indication of disease" (yea!) yet I was placed on high doses of Lialda - at $5 per pill!

And I am not even sick!  My flare-ups come once every 10 years.

There is obviously a BIG push of Lialda by the GI department of my medical center. 

When I called to complain about the price and to request Asacol again,

even the secretary tried to push Lialda on me by tempting me with 3-month discount cards on Lialda.

I have been an IBD sufferer since 1992, so I believe that I know what I am talking about when I say the Lialda's "improved"

delivery system is just a thin excuse for its outragous cost.

Stop whatever it is you're doing get down on your knees and give extra thanks...you're a very fortunate person! :-)

Post Edited (bbc) : 6/19/2008 9:58:38 PM (GMT-6)


seconder
Veteran Member


Date Joined Jun 2008
Total Posts : 610
   Posted 6/19/2008 7:58 AM (GMT -6)   

Felinis, you're entitled to your belief that the only improvement Lialda makes is in its profits for big pharma.  The skeptic in me doesn't necessarily disagree.  On the other hand, a once-a-day dosing regime for uc should help with compliance and reduce the costs associated with flare-ups of the disease, which are considerable.

If it worked for me, I don't know that I'd care what rationale spurred Lialda's development.  And, by your logic -- people should only take the least expensive drug -- you should be on sulfasalazine, not Asacol. 

In my case, it doesn't matter since my $10 copay doesn't change.  But, the cost for Asacol before my co-pay was $230 a month compared to $35 for the sulfa.  That alone indicates that Asacol hasn't gone off patent.  Drug companies have every right to recoup their R&D costs and patenting protects the incentive to create new medications.  We live in a capitalist society, and drug companies operate under those conditions.  (And why didn't you take the coupons and switch after you saved some dough?  That would have been one way to stick it to the man!)

On the other hand, you could live in Madagascar where a big bowl of plaster and mud is prescribed for intestinal disorders.  That's pretty cheap.

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